B4GN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B4GN3_HUMAN
• UniProt AC: Q6L9W6
• Protein Name: Beta-1,4-N-acetylgalactosaminyltransferase 3
• Gene Name: B4GALNT3
• Organism: Homo sapiens (Human).
• Sequence Length: 998
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Localizes to apical Golgi.
• Protein Description: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa..
• Protein Sequence: MGSPRAARPPLLLRPVKLLRRRFRLLLALAVVSVGLWTLYLELVASAQVGGNPLNRRYGSWRELAKALASRNIPAVDPHLQFYHPQRLSLEDHDIDQGVSSNSSYLKWNKPVPWLSEFRGRANLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGKIQFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEWTAPGEFGKFRSQISKPVSLSASHRYYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIIDSLSLSLFTNETFLQMDEVGHIPQTAASHVDSSNALPRDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLPLQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQENAYYQDRFSFQEYIKIDQPEKQGLEQPGFEENLLEESQYGEVAEETPASNNQNARMLEGRQTPASTLEQDATDYRLRSLRKLLAQPREGLLAPFSKRNSTASFPGRTSHIPVQQPEKRKQKPSPEPSQDSPHSDKWPPGHPVKNLPQMRGPRPRPAGDSPRKTQWLNQVESYIAEQRRGDRMRPQAPGRGWHGEEEVVAAAGQEGQVEGEEEGEEEEEEEDMSEVFEYVPVFDPVVNWDQTFSARNLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLNQRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQRVVRLSEYVSARGWQGIDPAGGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGFSWSHRAVVHFVVPVKNQARWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKRSKLRSYQYVKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLDVERLSLRNFFHHFHSKRGMWSRRQMKTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	O-linked_Glycosylation	ELAKALASRNIPAVD HHHHHHHHCCCCCCC	27.06	55834977
160	Phosphorylation	TLRKLAVSPKWTNYG HHHHHCCCCCCCHHE	18.37	-
229	Phosphorylation	GEFGKFRSQISKPVS CCCHHHHHCCCCCEE	34.69	-
236	Phosphorylation	SQISKPVSLSASHRY HCCCCCEECCCHHHH	25.74	-
405	Phosphorylation	AYYQDRFSFQEYIKI CCCCCCCCHHHHCCC	27.24	30631047
496	Phosphorylation	PFSKRNSTASFPGRT CCCCCCCCCCCCCCC	29.84	23025827
503	Phosphorylation	TASFPGRTSHIPVQQ CCCCCCCCCCCCCCC	30.48	28348404
504	Phosphorylation	ASFPGRTSHIPVQQP CCCCCCCCCCCCCCC	20.33	28348404
519	Phosphorylation	EKRKQKPSPEPSQDS HHCCCCCCCCCCCCC	49.26	29396449
523	Phosphorylation	QKPSPEPSQDSPHSD CCCCCCCCCCCCCCC	44.98	29396449
526	Phosphorylation	SPEPSQDSPHSDKWP CCCCCCCCCCCCCCC	19.51	29396449
555	Phosphorylation	RPRPAGDSPRKTQWL CCCCCCCCCCHHHHH	26.20	28348404
568	Phosphorylation	WLNQVESYIAEQRRG HHHHHHHHHHHHHCC	7.22	26330541
650	Phosphorylation	LDFQALRTDWIDLSC CCCCEEECCEEEEEE	36.21	27251275
946	Phosphorylation	DRIGGMNTKEFRDRW HHCCCCCCHHHHHHC	24.06	27251275
975	Phosphorylation	GLDVERLSLRNFFHH CCCHHHHHHHHHHHH	31.35	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B4GN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B4GN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B4GN3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of B4GN3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.