B3A3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B3A3_RAT
• UniProt AC: P23348
• Protein Name: Anion exchange protein 3
• Gene Name: Slc4a3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1227
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Plasma membrane anion exchange protein..
• Protein Sequence: MANGVIPPPGGPSPLPQVRVPLEEPPLGPDVEEEDDDLGKTLAVSRFGDLISKTPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHARRKRKKEKTSAPPSEGTPPIQEEGGAGAEEEEEEEEEEEGESEAEPVEPPPPGPPQKAKFSIGSDEDDSPGLSIKAPCAKALPSVGLPSDQSPQRSGSSPSPRARASRISTEKSRPWSPSASYDLRERLCPGSALGNPGPEQRVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRIQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAQGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSVNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGSVPFLEQPAAAFVRLSEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLGAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYVAPGKELSLEMGGSEATSEDDPLQRTGSVFGGLVRDVKRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFHKLYKVFTEHPLLPFYPPEEALEPGLELNSSALPPTEGPPGPRNQPNTALLSLILMLGTFLIAFFLRKFRNSRFLGGKARRVIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPHKRTWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIFMPAKHHPEQPYVTKVKTWRMHLFTFIQLGCIALLWVVKSTVASLAFPFLLLLTVPLRRCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	EKPSRSYSERDFEFH CCCCCCCCHHHEEEE	27.66	22817900
167	Phosphorylation	PPQKAKFSIGSDEDD CCCCCEEECCCCCCC	25.90	25403869
170	Phosphorylation	KAKFSIGSDEDDSPG CCEEECCCCCCCCCC	35.84	30411139
175	Phosphorylation	IGSDEDDSPGLSIKA CCCCCCCCCCCCCCC	32.94	30240740
195	Phosphorylation	LPSVGLPSDQSPQRS CCCCCCCCCCCCCCC	54.01	28551015
198	Phosphorylation	VGLPSDQSPQRSGSS CCCCCCCCCCCCCCC	28.17	30240740
204	Phosphorylation	QSPQRSGSSPSPRAR CCCCCCCCCCCHHHH	40.08	25403869
205	Phosphorylation	SPQRSGSSPSPRARA CCCCCCCCCCHHHHH	32.68	22668510
207	Phosphorylation	QRSGSSPSPRARASR CCCCCCCCHHHHHHH	29.03	22668510
224	Phosphorylation	TEKSRPWSPSASYDL CCCCCCCCCCCCCCH	16.20	30240740
294	Methylation	PSRIQGGRGSPSGLA CCCCCCCCCCCCCHH	49.60	-
296	Phosphorylation	RIQGGRGSPSGLAPI CCCCCCCCCCCHHHH	17.96	30411139
298	Phosphorylation	QGGRGSPSGLAPILR CCCCCCCCCHHHHHH	48.40	27097102
642	Ubiquitination	RREREQTKVEMTTRG HHHHHCCCEEEECCC	35.57	-
656	Ubiquitination	GGYVAPGKELSLEMG CCCCCCCCEEEEEEC	55.19	-
868	N-linked_Glycosylation	LEPGLELNSSALPPT CCCCCCCCCCCCCCC	25.25	-
1160	S-palmitoylation	FTFIQLGCIALLWVV HHHHHHHHHHHHHHH	1.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B3A3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B3A3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B3A3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of B3A3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.