B3A2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B3A2_RAT
• UniProt AC: P23347
• Protein Name: Anion exchange protein 2
• Gene Name: Slc4a2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1234
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Plasma membrane anion exchange protein of wide distribution..
• Protein Sequence: MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEEDELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEVGEAEGFRAPPQQPSPASSPSAVQFFLQEDEGTDRKAERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELQLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGHHHAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEEAFFSFCKSNQLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSVSNDSEADSSSNNMTWAATTLAPDNSSASGQERPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDEYNEMPMPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	SAPRRPASGADSLHT CCCCCCCCCCCCCCC	36.88	25575281
14	Phosphorylation	RPASGADSLHTPEPE CCCCCCCCCCCCCCC	22.86	25575281
17	Phosphorylation	SGADSLHTPEPESLS CCCCCCCCCCCCCCC	34.34	25575281
22	Phosphorylation	LHTPEPESLSPGTPG CCCCCCCCCCCCCCC	44.88	25575281
24	Phosphorylation	TPEPESLSPGTPGFP CCCCCCCCCCCCCCC	30.48	25575281
27	Phosphorylation	PESLSPGTPGFPEQE CCCCCCCCCCCCHHH	24.51	25575281
113	Phosphorylation	PRRRPGASPTGETPT CCCCCCCCCCCCCCC	28.98	22108457
115	Phosphorylation	RRPGASPTGETPTIE CCCCCCCCCCCCCCC	45.19	22108457
118	Phosphorylation	GASPTGETPTIEEGE CCCCCCCCCCCCCCC	27.38	25532521
120	Phosphorylation	SPTGETPTIEEGEED CCCCCCCCCCCCCCC	48.73	21630457
145	Phosphorylation	RAPPQQPSPASSPSA CCCCCCCCCCCCCHH	28.85	22108457
148	Phosphorylation	PQQPSPASSPSAVQF CCCCCCCCCCHHHHH	46.28	16641100
149	Phosphorylation	QQPSPASSPSAVQFF CCCCCCCCCHHHHHH	25.61	16641100
151	Phosphorylation	PSPASSPSAVQFFLQ CCCCCCCHHHHHHHH	42.91	25575281
170	Phosphorylation	TDRKAERTSPSPPTQ CCCCCCCCCCCCCCC	36.17	22108457
171	Phosphorylation	DRKAERTSPSPPTQT CCCCCCCCCCCCCCC	29.60	22108457
173	Phosphorylation	KAERTSPSPPTQTPH CCCCCCCCCCCCCCC	43.19	22108457
176	Phosphorylation	RTSPSPPTQTPHQEA CCCCCCCCCCCCCCC	48.75	22108457
178	Phosphorylation	SPSPPTQTPHQEAAP CCCCCCCCCCCCCCC	25.80	22108457
240	Phosphorylation	QERRRIGSMTGVEQA HHHHCHHCCCCHHHH	15.70	22108457
242	Phosphorylation	RRRIGSMTGVEQALL HHCHHCCCCHHHHHC	39.51	22108457
254	Phosphorylation	ALLPRVPTDESEAQT HHCCCCCCCHHHHHH	49.93	22108457
257	Phosphorylation	PRVPTDESEAQTLAT CCCCCCHHHHHHHHH	40.83	22673903
271	Methylation	TADLDLMKSHRFEDV HHCHHHHHHCCCCCC	50.86	-
298	Methylation	KGSTQAAREGREPGP CCCHHHHHCCCCCCC	50.33	-
434	Phosphorylation	PSDEKEFSFPRNISA CCCCCCCCCCCCCCC	35.12	22673903
440	Phosphorylation	FSFPRNISAGSLGSL CCCCCCCCCCHHHHH	30.08	22673903
443	Phosphorylation	PRNISAGSLGSLLGH CCCCCCCHHHHHHCC	29.31	22673903
446	Phosphorylation	ISAGSLGSLLGHHHA CCCCHHHHHHCCCCC	26.22	22673903
456	Phosphorylation	GHHHAQGTESDPHVT CCCCCCCCCCCCCCC	21.89	22673903
458	Phosphorylation	HHAQGTESDPHVTEP CCCCCCCCCCCCCCC	57.17	22673903
463	Phosphorylation	TESDPHVTEPLIGGV CCCCCCCCCCCCCCC	28.93	22673903
572	Phosphorylation	DYHEIGRSISTLMSD CHHHHHHHHHHHHCC	18.71	30181290
574	Phosphorylation	HEIGRSISTLMSDKQ HHHHHHHHHHHCCHH	19.41	30181290
575	Phosphorylation	EIGRSISTLMSDKQF HHHHHHHHHHCCHHH	25.47	30181290
578	Phosphorylation	RSISTLMSDKQFHEA HHHHHHHCCHHHHHH	44.78	30181290
650	Ubiquitination	PGAGLEPKSAQDKAL CCCCCCCCCHHHHHH	49.39	-
856	N-linked_Glycosylation	LHGCSVSNDSEADSS CCCCCCCCCCCCCCC	55.46	-
866	N-linked_Glycosylation	EADSSSNNMTWAATT CCCCCCCCCCEEEEE	31.07	-
878	N-linked_Glycosylation	ATTLAPDNSSASGQE EEEECCCCCCCCCCC	36.48	-
1073	Acetylation	KAVAPGDKPKIQEVK HHCCCCCCCCHHHHH	54.87	22902405
1166	S-palmitoylation	FTALQLLCLALLWAV HHHHHHHHHHHHHHH	2.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B3A2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B3A2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B3A2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of B3A2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.