AZI2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AZI2_MOUSE
• UniProt AC: Q9QYP6
• Protein Name: 5-azacytidine-induced protein 2
• Gene Name: Azi2
• Organism: Mus musculus (Mouse).
• Sequence Length: 405
• Subcellular Localization: Cytoplasm .
• Protein Description: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1..
• Protein Sequence: MDTLVEDDICILNHEKAHRREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKAYHAYREVCIDRDNLKNQLEKINKDNSESLKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLKIHGLEQELGLLRKECSDLRTELQKARQTGPPQEDILQGRDVIRPSLSREEHVPHQGLHHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKKACTPVGCVEDLGRDSTKLHLTNFTATYKRHPSLSPNGKAPCYAPSSPLPGDRKVFSDKAVLQSWTDNERLVPNDGADFPEHSSYGRNSLEDNSWVFPSPPKSSETAFGENKSKILPLSNLPPLHYLDQQNQNCLYKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTLVEDDIC -----CCCCCCCCEE	31.25	28507225
60	Phosphorylation	KDSEKENSFLKKRIR CCHHHHHHHHHHHHH	32.80	20495213
82	Phosphorylation	GARADEETSSVGREQ CCCCCCCCCCCCHHH	25.01	29899451
83	Phosphorylation	ARADEETSSVGREQV CCCCCCCCCCCHHHH	26.72	23984901
84	Phosphorylation	RADEETSSVGREQVN CCCCCCCCCCHHHHH	35.69	23684622
121	Phosphorylation	INKDNSESLKMLNEQ HCCCCHHHHHHHHHH	32.86	23140645
131	Phosphorylation	MLNEQLQSKEVELLQ HHHHHHHHHHHHHHH	39.10	28066266
214	Phosphorylation	GRDVIRPSLSREEHV CCCCCCCCCCCCCCC	29.18	28066266
216	Phosphorylation	DVIRPSLSREEHVPH CCCCCCCCCCCCCCC	41.82	28066266
300	Phosphorylation	ATYKRHPSLSPNGKA EEECCCCCCCCCCCC	35.04	22817900
302	Phosphorylation	YKRHPSLSPNGKAPC ECCCCCCCCCCCCCC	22.21	22817900
310	Phosphorylation	PNGKAPCYAPSSPLP CCCCCCCCCCCCCCC	22.08	26643407
313	Phosphorylation	KAPCYAPSSPLPGDR CCCCCCCCCCCCCCC	36.09	26824392
314	Phosphorylation	APCYAPSSPLPGDRK CCCCCCCCCCCCCCC	29.42	30352176
331	Phosphorylation	SDKAVLQSWTDNERL CCHHHHHHCCCCCCC	27.99	25521595
333	Phosphorylation	KAVLQSWTDNERLVP HHHHHHCCCCCCCCC	33.91	29472430
350	Phosphorylation	GADFPEHSSYGRNSL CCCCCCCCCCCCCCC	24.48	29899451
356	Phosphorylation	HSSYGRNSLEDNSWV CCCCCCCCCCCCCCC	31.60	21743459
361	Phosphorylation	RNSLEDNSWVFPSPP CCCCCCCCCCCCCCC	36.62	29233185
366	Phosphorylation	DNSWVFPSPPKSSET CCCCCCCCCCCCCCC	42.23	26643407
370	Phosphorylation	VFPSPPKSSETAFGE CCCCCCCCCCCCCCC	38.90	25293948
371	Phosphorylation	FPSPPKSSETAFGEN CCCCCCCCCCCCCCC	45.13	25293948
373	Phosphorylation	SPPKSSETAFGENKS CCCCCCCCCCCCCCC	29.27	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AZI2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AZI2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AZI2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AZI2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.