AVT3_SCHPO - dbPTM
AVT3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AVT3_SCHPO
UniProt AC Q10074
Protein Name Vacuolar amino acid transporter 3
Gene Name avt3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 656
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Vacuole membrane
Multi-pass membrane protein.
Protein Description Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine (By similarity). Required for spore formation..
Protein Sequence MSNSQSIKIKKPRSNENFASGSYSSRRSQQIHRLSHSPMAEGFHKPKLNISPSESNLPNNVAENTTDTPVNYGSIRDENHNSRKGKDVTLNSDEAHSENVPSTSEDPDVVRRHLGGQAADDDNFSSLQLQGGDMHRQVYRWQQEVDQNKQIRRGRSRSFSAKVSDPNLHLRSVQDMKQAGGMRRDFLRNRASSISMSSNAHGNPNFLNRNFIEFLSVYGHFAGEELSEEDEDEDTDDFAMPRDVNPSLIHSTVPSEQEPLISRHGRYKLQTPGNASNGKAVLLLLKSFVGTGVLFLPKAFKLGGLVFSSATLLIVGVLSHICFLLLIQTRMKVPGSFGDIGGTLYGPHMRFAILASIVVSQIGFSSAYISFVASTLQACVKVISTTHREYHLAVFIFIQFLVFVPLSLVRKISKLSATALIADVFILLGILYLYFWDVITLATKGIADVAMFNKTDFSLFIGVAIFTYEGICLILPIQEQMAKPKNLPKLLTGVMAAISLLFISIGLLSYAAFGSKVKTVVILNMPESTFTVIIQFLYAIAILLSTPLQLFPAIAIIEQGIFTRSGKRNRKIKWRKNYLRVLIVILAILISWAGSSRLDLFVSMVGSVCCIPLIYMYPPMLHYKACANNWILRTLDIFMFTIGAFAMAFTTYMTFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationIKIKKPRSNENFASG
CEECCCCCCCCCCCC		57.9628889911
20PhosphorylationRSNENFASGSYSSRR
CCCCCCCCCCCCCHH		24.9229996109
22PhosphorylationNENFASGSYSSRRSQ
CCCCCCCCCCCHHHH		21.2429996109
23PhosphorylationENFASGSYSSRRSQQ
CCCCCCCCCCHHHHH		17.7529996109
24PhosphorylationNFASGSYSSRRSQQI
CCCCCCCCCHHHHHH		21.0429996109
25PhosphorylationFASGSYSSRRSQQIH
CCCCCCCCHHHHHHH		24.3929996109
28PhosphorylationGSYSSRRSQQIHRLS
CCCCCHHHHHHHHHC		25.9025720772
35PhosphorylationSQQIHRLSHSPMAEG
HHHHHHHCCCCCCCC		23.1329996109
37PhosphorylationQIHRLSHSPMAEGFH
HHHHHCCCCCCCCCC		17.0028889911
51PhosphorylationHKPKLNISPSESNLP
CCCCCCCCCCCCCCC		22.6925720772
53PhosphorylationPKLNISPSESNLPNN
CCCCCCCCCCCCCCC		47.0328889911
55PhosphorylationLNISPSESNLPNNVA
CCCCCCCCCCCCCCC		48.2621712547
65PhosphorylationPNNVAENTTDTPVNY
CCCCCCCCCCCCCCH		19.9729996109
66PhosphorylationNNVAENTTDTPVNYG
CCCCCCCCCCCCCHH		49.8329996109
68PhosphorylationVAENTTDTPVNYGSI
CCCCCCCCCCCHHCC		27.3529996109
72PhosphorylationTTDTPVNYGSIRDEN
CCCCCCCHHCCCCCC		16.6921712547
74PhosphorylationDTPVNYGSIRDENHN
CCCCCHHCCCCCCCC		12.2329996109
89PhosphorylationSRKGKDVTLNSDEAH
CCCCCCCCCCCHHHH		30.2925720772
92PhosphorylationGKDVTLNSDEAHSEN
CCCCCCCCHHHHHCC		39.6825720772
97PhosphorylationLNSDEAHSENVPSTS
CCCHHHHHCCCCCCC		37.6029996109
102PhosphorylationAHSENVPSTSEDPDV
HHHCCCCCCCCCCHH		40.0425720772
104PhosphorylationSENVPSTSEDPDVVR
HCCCCCCCCCCHHHH		44.3229996109
125PhosphorylationAADDDNFSSLQLQGG
CCCCCCCCCEEECCC		36.0729996109
156PhosphorylationKQIRRGRSRSFSAKV
HHHHCCCCCCCCCCC		34.7925720772
158PhosphorylationIRRGRSRSFSAKVSD
HHCCCCCCCCCCCCC		25.4629996109
160PhosphorylationRGRSRSFSAKVSDPN
CCCCCCCCCCCCCCC		28.5525720772
164PhosphorylationRSFSAKVSDPNLHLR
CCCCCCCCCCCCCCC		46.7928889911
172PhosphorylationDPNLHLRSVQDMKQA
CCCCCCCCHHHHHHC		30.4128889911
192PhosphorylationDFLRNRASSISMSSN
HHHHHCHHHCCCCCC		25.6029996109
193PhosphorylationFLRNRASSISMSSNA
HHHHCHHHCCCCCCC		20.0728889911
195PhosphorylationRNRASSISMSSNAHG
HHCHHHCCCCCCCCC		17.9829996109
197PhosphorylationRASSISMSSNAHGNP
CHHHCCCCCCCCCCC		17.4128889911
198PhosphorylationASSISMSSNAHGNPN
HHHCCCCCCCCCCCC		29.4229996109
247PhosphorylationMPRDVNPSLIHSTVP
CCCCCCHHHHCCCCC		34.4525720772
251PhosphorylationVNPSLIHSTVPSEQE
CCHHHHCCCCCCCCC		24.8925720772
252PhosphorylationNPSLIHSTVPSEQEP
CHHHHCCCCCCCCCC		23.4429996109
255PhosphorylationLIHSTVPSEQEPLIS
HHCCCCCCCCCCCHH		47.8029996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AVT3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AVT3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AVT3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AVT3_SCHPO !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AVT3_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37; SER-53 AND SER-172,AND MASS SPECTROMETRY.

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