AVR2A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AVR2A_MOUSE
• UniProt AC: P27038
• Protein Name: Activin receptor type-2A
• Gene Name: Acvr2a
• Organism: Mus musculus (Mouse).
• Sequence Length: 513
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. [PubMed: 23527555]
• Protein Sequence: MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	N-linked_Glycosylation	NWERDRTNQTGVEPC CCCCCCCCCCCCCCC	38.01	-
66	N-linked_Glycosylation	HCFATWKNISGSIEI EEEEEEEECCCCEEE	25.81	-
184	Phosphorylation	DPGPPPPSPLLGLKP CCCCCCCCCCCCCCC	33.67	28973931
280	Ubiquitination	GSLSDFLKANVVSWN CCHHHHHHHCCCCHH	37.60	-
496	Phosphorylation	ITTEDIVTVVTMVTN CCHHHCEEEEEEEEC	15.03	29233185
499	Phosphorylation	EDIVTVVTMVTNVDF HHCEEEEEEEECCCC	11.11	29233185
502	Phosphorylation	VTVVTMVTNVDFPPK EEEEEEEECCCCCCC	20.78	29233185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AVR2A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AVR2A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AVR2A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAGI2_MOUSE	Magi2	physical	10681527

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.