AUXI_MOUSE - dbPTM
AUXI_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AUXI_MOUSE
UniProt AC Q80TZ3
Protein Name Putative tyrosine-protein phosphatase auxilin {ECO:0000305}
Gene Name Dnajc6 {ECO:0000312|MGI:MGI:1919935}
Organism Mus musculus (Mouse).
Sequence Length 938
Subcellular Localization
Protein Description Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons..
Protein Sequence MTNPKSGVAESAGLACSRAAAGENRMKDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVSSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKAITVSPVPFFNKQRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVIVSMYHLRSTIGSRLQAKVTNTQIFQLQFHSGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVTLDIEVQPQDKVIDLTPPWEHYCTKDVNPSILFSSQQEHQDTLALGGQAPADLPPDHPRNLGQGGFFASLCWQDQKSEKSRCEEDHAALVNQESEQSDDELLTLSSPHGNAEGDKPHGAKKPGKKQQEPAAPPPPEEVDLLGLEGSDVSTNFSSLAAPPSNSELLSDLFGGVGATGPAQAGQAGVEDVFHPSGPVSAQSTPRRTATSASASPTLRVGEGATFDPFGAPAKPPGQDLLGSFLNTSSASSDPFLQPTRSPSPTVHASSTPAVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTGSSHGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQPAGYNWQQTQSKPQSSMPHSSPQNRPNYNVSFSAMPAGQSERGKGSTNLEGKQKAADFEDLLSSQGFNAHKDKKGPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTMHTVLWAGETKWKPVGMADLVTPEQVKKVYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGQKPLY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6 (in isoform 3)Phosphorylation-39.49-
7 (in isoform 3)Phosphorylation-28.87-
11 (in isoform 3)Phosphorylation-20.2129899451
12 (in isoform 3)Phosphorylation-14.4425177544
13 (in isoform 3)Phosphorylation-24.0822807455
16 (in isoform 3)Phosphorylation-3.2122807455
29PhosphorylationGENRMKDSENKGASS
CCCCCCCCCCCCCCC		37.2420415495
35PhosphorylationDSENKGASSPDMEPS
CCCCCCCCCCCCCCC		51.5825521595
36PhosphorylationSENKGASSPDMEPSY
CCCCCCCCCCCCCCC		25.1225521595
41 (in isoform 3)Phosphorylation-26.6429899451
42PhosphorylationSSPDMEPSYGGGLFD
CCCCCCCCCCCCHHH		24.0925521595
43PhosphorylationSPDMEPSYGGGLFDM
CCCCCCCCCCCHHHH		30.4229899451
47 (in isoform 3)Phosphorylation-3.5829899451
63 (in isoform 3)Ubiquitination-49.1522790023
63UbiquitinationGRLFSNLKDNLKDTL
HHHHHHCHHHHHHHH		49.1522790023
65 (in isoform 3)Phosphorylation-47.6129899451
66 (in isoform 3)Phosphorylation-8.3429899451
83PhosphorylationRVIQSVSSYTKGDLD
HHHHHHHHCCCCCCC		34.3729899451
93 (in isoform 3)Ubiquitination-11.17-
137PhosphorylationHYTVYNLSPKSYRTA
EEEEEECCCCHHHHH		27.0020415495
221PhosphorylationGPAVRLLYAKRPGIG
CHHHHHHHCCCCCCC		18.05-
257PhosphorylationRPHFKPLTIKAITVS
CCCCCCCEEEEEEEE		29.03-
378PhosphorylationACDVPEKYPQLFQVT
CCCCCHHCCCCEEEE		8.4422807455
400PhosphorylationQDKVIDLTPPWEHYC
CCCEEECCCCHHHHC		24.4519060867
408PhosphorylationPPWEHYCTKDVNPSI
CCHHHHCCCCCCHHH		24.1021183079
455S-palmitoylationGGFFASLCWQDQKSE
CCHHHHHHCCCCHHH		2.5828680068
461PhosphorylationLCWQDQKSEKSRCEE
HHCCCCHHHHHHCHH		44.6221183079
464PhosphorylationQDQKSEKSRCEEDHA
CCCHHHHHHCHHHHH		37.8029899451
478PhosphorylationAALVNQESEQSDDEL
HHHHCCCCCCCCCCE		31.0419060867
481PhosphorylationVNQESEQSDDELLTL
HCCCCCCCCCCEEEC		42.8719060867
487PhosphorylationQSDDELLTLSSPHGN
CCCCCEEECCCCCCC		36.9022807455
489PhosphorylationDDELLTLSSPHGNAE
CCCEEECCCCCCCCC		36.2729899451
490PhosphorylationDELLTLSSPHGNAEG
CCEEECCCCCCCCCC		24.8319060867
588O-linked_GlycosylationAQSTPRRTATSASAS
CCCCCCCCCCCCCCC		35.256370239
588PhosphorylationAQSTPRRTATSASAS
CCCCCCCCCCCCCCC		35.2523527152
590PhosphorylationSTPRRTATSASASPT
CCCCCCCCCCCCCCE		24.9825521595
591PhosphorylationTPRRTATSASASPTL
CCCCCCCCCCCCCEE		20.1225521595
593PhosphorylationRRTATSASASPTLRV
CCCCCCCCCCCEEEC		29.1022324799
595PhosphorylationTATSASASPTLRVGE
CCCCCCCCCEEECCC		18.8725521595
597PhosphorylationTSASASPTLRVGEGA
CCCCCCCEEECCCCC		25.3825521595
631PhosphorylationFLNTSSASSDPFLQP
HHCCCCCCCCCCCCC		36.9029899451
641PhosphorylationPFLQPTRSPSPTVHA
CCCCCCCCCCCCCCC		32.0129899451
643PhosphorylationLQPTRSPSPTVHASS
CCCCCCCCCCCCCCC		34.1522807455
645PhosphorylationPTRSPSPTVHASSTP
CCCCCCCCCCCCCCC		29.3030482847
649PhosphorylationPSPTVHASSTPAVNI
CCCCCCCCCCCCCCC		21.6230482847
650PhosphorylationSPTVHASSTPAVNIQ
CCCCCCCCCCCCCCC		38.9122807455
651PhosphorylationPTVHASSTPAVNIQP
CCCCCCCCCCCCCCC		16.8722807455
679PhosphorylationGFGMGSKSAATSPTG
CCCCCCCCCCCCCCC		25.4923375375
682PhosphorylationMGSKSAATSPTGSSH
CCCCCCCCCCCCCCC		34.6520415495
683PhosphorylationGSKSAATSPTGSSHG
CCCCCCCCCCCCCCC		18.7520415495
685PhosphorylationKSAATSPTGSSHGTP
CCCCCCCCCCCCCCC		49.8423375375
687PhosphorylationAATSPTGSSHGTPTH
CCCCCCCCCCCCCCC		22.9527841257
688PhosphorylationATSPTGSSHGTPTHQ
CCCCCCCCCCCCCCC		27.5520415495
691PhosphorylationPTGSSHGTPTHQSKP
CCCCCCCCCCCCCCC		21.4227841257
693PhosphorylationGSSHGTPTHQSKPQT
CCCCCCCCCCCCCCC		32.1720415495
696PhosphorylationHGTPTHQSKPQTLDP
CCCCCCCCCCCCCCC		38.4020415495
721PhosphorylationSFASKPTTPTGLGGG
CCCCCCCCCCCCCCC		27.6427841257
733PhosphorylationGGGFPPLSSPQKASP
CCCCCCCCCCCCCCC		45.8327841257
734PhosphorylationGGFPPLSSPQKASPQ
CCCCCCCCCCCCCCC		38.7520415495
765PhosphorylationTQSKPQSSMPHSSPQ
CCCCCCCCCCCCCCC		30.9624759943
812PhosphorylationADFEDLLSSQGFNAH
HCHHHHHHHCCCCCC		28.1029899451
813PhosphorylationDFEDLLSSQGFNAHK
CHHHHHHHCCCCCCC		34.0029899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AUXI_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AUXI_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AUXI_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AUXI_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AUXI_MOUSE

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Related Literatures of Post-Translational Modification

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