AUHM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AUHM_MOUSE
• UniProt AC: Q9JLZ3
• Protein Name: Methylglutaconyl-CoA hydratase, mitochondrial
• Gene Name: Auh
• Organism: Mus musculus (Mouse).
• Sequence Length: 314
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (By similarity). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (By similarity). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (By similarity). Has very low enoyl-CoA hydratase activity. [PubMed: 10072761 Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs]
• Protein Sequence: MAAAAPGALGALRTGRVRLVAACCARLGPAAWARGTAPRRGYSSEVKTEDELRVRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRSVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Acetylation	RGYSSEVKTEDELRV CCCCCCCCCHHHHHH	41.99	23576753
75	Succinylation	GINRAYGKNALSKNL EECHHHCCCCCCHHH	26.77	-
75	Glutarylation	GINRAYGKNALSKNL EECHHHCCCCCCHHH	26.77	24703693
75	Succinylation	GINRAYGKNALSKNL EECHHHCCCCCCHHH	26.77	23806337
75	Acetylation	GINRAYGKNALSKNL EECHHHCCCCCCHHH	26.77	23576753
80	Acetylation	YGKNALSKNLLKMLS HCCCCCCHHHHHHHH	53.09	24062335
80	Succinylation	YGKNALSKNLLKMLS HCCCCCCHHHHHHHH	53.09	26388266
84	Succinylation	ALSKNLLKMLSKAVD CCCHHHHHHHHHHHH	40.75	-
84	Succinylation	ALSKNLLKMLSKAVD CCCHHHHHHHHHHHH	40.75	23806337
84	Acetylation	ALSKNLLKMLSKAVD CCCHHHHHHHHHHHH	40.75	23864654
88	Acetylation	NLLKMLSKAVDALKS HHHHHHHHHHHHHHC	48.76	23576753
88	Succinylation	NLLKMLSKAVDALKS HHHHHHHHHHHHHHC	48.76	-
88	Glutarylation	NLLKMLSKAVDALKS HHHHHHHHHHHHHHC	48.76	24703693
88	Succinylation	NLLKMLSKAVDALKS HHHHHHHHHHHHHHC	48.76	23806337
94	Acetylation	SKAVDALKSDKKVRT HHHHHHHHCCCCEEE	59.33	23201123
97	Acetylation	VDALKSDKKVRTIII HHHHHCCCCEEEEEE	61.33	23201123
98	Acetylation	DALKSDKKVRTIIIR HHHHCCCCEEEEEEC	41.77	2395299
106	Phosphorylation	VRTIIIRSEVPGIFC EEEEEECCCCCCEEE	32.32	-
113	S-nitrosocysteine	SEVPGIFCAGADLKE CCCCCEEECCCCHHH	3.01	-
113	S-nitrosylation	SEVPGIFCAGADLKE CCCCCEEECCCCHHH	3.01	24895380
119	Acetylation	FCAGADLKERAKMHS EECCCCHHHHHHHHH	45.78	23576753
119	Glutarylation	FCAGADLKERAKMHS EECCCCHHHHHHHHH	45.78	24703693
119	Succinylation	FCAGADLKERAKMHS EECCCCHHHHHHHHH	45.78	-
119	Succinylation	FCAGADLKERAKMHS EECCCCHHHHHHHHH	45.78	23806337
123	Glutarylation	ADLKERAKMHSSEVG CCHHHHHHHHHCCCH	43.28	24703693
123	Acetylation	ADLKERAKMHSSEVG CCHHHHHHHHHCCCH	43.28	23806337
123	Succinylation	ADLKERAKMHSSEVG CCHHHHHHHHHCCCH	43.28	-
123	Succinylation	ADLKERAKMHSSEVG CCHHHHHHHHHCCCH	43.28	23806337
135	Acetylation	EVGPFVSKIRSVIND CCHHHHHHHHHHHHH	36.52	23864654
135	Succinylation	EVGPFVSKIRSVIND CCHHHHHHHHHHHHH	36.52	23806337
135	Succinylation	EVGPFVSKIRSVIND CCHHHHHHHHHHHHH	36.52	-
179	Succinylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	23806337
179	Malonylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	26320211
179	Acetylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	23576753
179	Glutarylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	24703693
179	Succinylation	RVAASSAKMGLVETK HHHHHHCCCCCEEEE	35.13	-
186	Acetylation	KMGLVETKLAIIPGG CCCCEEEEEEEECCC	23.55	23576753
186	Glutarylation	KMGLVETKLAIIPGG CCCCEEEEEEEECCC	23.55	24703693
186	Succinylation	KMGLVETKLAIIPGG CCCCEEEEEEEECCC	23.55	23806337
186	Succinylation	KMGLVETKLAIIPGG CCCCEEEEEEEECCC	23.55	-
224	Acetylation	VLDGQEAKAVGLISH ECCCHHHHHHHHHHH	42.74	23201123
304	Succinylation	LEGLLAFKEKRPPRY HHHHHHHHCCCCCCC	57.63	23806337
304	Succinylation	LEGLLAFKEKRPPRY HHHHHHHHCCCCCCC	57.63	-
304	Acetylation	LEGLLAFKEKRPPRY HHHHHHHHCCCCCCC	57.63	23806337
304	Glutarylation	LEGLLAFKEKRPPRY HHHHHHHHCCCCCCC	57.63	24703693

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AUHM_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AUHM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AUHM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AUHM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.