ATX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATX1_MOUSE
• UniProt AC: P54254
• Protein Name: Ataxin-1
• Gene Name: Atxn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 791
• Subcellular Localization: Cytoplasm . Nucleus . Colocalizes with USP7 in the nucleus.
• Protein Description: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). May be involved in RNA metabolism (By similarity). In concert with CIC and ATXN1L, involved in brain development. [PubMed: 28288114]
• Protein Sequence: MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGIRGHGGGRHGSAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPSGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLSRAAGLVNPGSPPPPTQQNQYIHISSSPQSSGRATSPPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKASSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLEAQQTTHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGGLPQHLVIPGNQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPTTASPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEESHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKQAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLSKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	O-linked_Glycosylation	KREIPATSRPSEEKA CCCCCCCCCCCHHHC	44.28	30059200
23	Phosphorylation	KREIPATSRPSEEKA CCCCCCCCCCCHHHC	44.28	25338131
62	Phosphorylation	HGGGRHGSAGTSGEH CCCCCCCCCCCCCCC	19.87	26824392
65	Phosphorylation	GRHGSAGTSGEHGLQ CCCCCCCCCCCCCCC	33.02	27742792
66	Phosphorylation	RHGSAGTSGEHGLQG CCCCCCCCCCCCCCC	41.06	25266776
81	O-linked_Glycosylation	MGLHKALSAGLDYSP CHHHHHHHCCCCCCC	25.75	9417563
81	Phosphorylation	MGLHKALSAGLDYSP CHHHHHHHCCCCCCC	25.75	26239621
86	Phosphorylation	ALSAGLDYSPPSAPR HHHCCCCCCCCCCCC	28.28	26239621
87	Phosphorylation	LSAGLDYSPPSAPRS HHCCCCCCCCCCCCC	29.96	26824392
90	Phosphorylation	GLDYSPPSAPRSVPT CCCCCCCCCCCCCCC	55.05	29472430
213	Phosphorylation	AGLVNPGSPPPPTQQ CCCCCCCCCCCCCCC	35.18	27087446
218	Phosphorylation	PGSPPPPTQQNQYIH CCCCCCCCCCCCEEE	48.86	27087446
223	Phosphorylation	PPTQQNQYIHISSSP CCCCCCCEEEEECCC	11.30	25619855
227	Phosphorylation	QNQYIHISSSPQSSG CCCEEEEECCCCCCC	15.59	21082442
228	Phosphorylation	NQYIHISSSPQSSGR CCEEEEECCCCCCCC	45.49	21082442
229	Phosphorylation	QYIHISSSPQSSGRA CEEEEECCCCCCCCC	21.84	21082442
232	Phosphorylation	HISSSPQSSGRATSP EEECCCCCCCCCCCC	37.84	25619855
233	Phosphorylation	ISSSPQSSGRATSPP EECCCCCCCCCCCCC	27.35	25619855
237	Phosphorylation	PQSSGRATSPPPIPV CCCCCCCCCCCCCCC	40.17	26060331
238	Phosphorylation	QSSGRATSPPPIPVH CCCCCCCCCCCCCCC	34.13	26060331
251	Phosphorylation	VHLHPHQTMIPHTLT CCCCCCCCCCCCEEE	17.65	26060331
256	Phosphorylation	HQTMIPHTLTLGPSS CCCCCCCEEEECCCC	18.98	26060331
258	Phosphorylation	TMIPHTLTLGPSSQV CCCCCEEEECCCCEE	30.72	26060331
262	Phosphorylation	HTLTLGPSSQVVVQY CEEEECCCCEEEEEE	31.44	26060331
263	Phosphorylation	TLTLGPSSQVVVQYS EEEECCCCEEEEEEE	30.08	26060331
342	Phosphorylation	RHVVVHPSPADYSSR CCEEECCCCCCCCCC	20.17	25338131
364	Phosphorylation	SVMVLPNSSTPSADL EEEECCCCCCCCHHH	33.38	23984901
365	Phosphorylation	VMVLPNSSTPSADLE EEECCCCCCCCHHHH	51.48	23984901
366	Phosphorylation	MVLPNSSTPSADLEA EECCCCCCCCHHHHH	22.53	23984901
368	Phosphorylation	LPNSSTPSADLEAQQ CCCCCCCCHHHHHHH	34.21	23984901
376	Phosphorylation	ADLEAQQTTHREASP HHHHHHHHCCCCCCC	16.70	23984901
377	Phosphorylation	DLEAQQTTHREASPS HHHHHHHCCCCCCCC	18.01	23984901
382	Phosphorylation	QTTHREASPSTLNDK HHCCCCCCCCCCCCC	18.03	25521595
384	Phosphorylation	THREASPSTLNDKSG CCCCCCCCCCCCCCC	42.93	28833060
385	Phosphorylation	HREASPSTLNDKSGL CCCCCCCCCCCCCCC	32.72	28833060
585	Ubiquitination	AEISNDLKIDSSTVE HHHCCCCCCCHHHHH	47.53	-
685	Ubiquitination	DPASVLLKQAKTDSL CHHHHHHHHHCCCCC	44.01	22790023
689	Phosphorylation	VLLKQAKTDSLAGSR HHHHHHCCCCCCCCH	33.56	23737553
691	Phosphorylation	LKQAKTDSLAGSRHR HHHHCCCCCCCCHHH	25.92	23737553
695	Phosphorylation	KTDSLAGSRHRYAEQ CCCCCCCCHHHHHHH	21.21	23737553
751	Phosphorylation	ATRKRRWSAPETRKL CCCCCCCCCCCHHCC	31.94	18388127
755	Phosphorylation	RRWSAPETRKLEKSE CCCCCCCHHCCCCCC	31.85	25777480
787	Phosphorylation	KICIEGRSNVGK--- EEEEECCCCCCC---	46.88	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
751	S	Phosphorylation	Kinase	MSK1	Q8C050	PSP
751	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
751	S	Phosphorylation	Sumoylation is dependent on nuclear localization and phosphorylation at Ser-751.	-
751	S	Sumoylation	Sumoylation is dependent on nuclear localization and phosphorylation at Ser-751.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATX1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RORA_MOUSE	Rora	physical	17110330
KAT5_MOUSE	Kat5	physical	17110330

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.