dbPTM

ATX10_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATX10_RAT
UniProt AC	Q9ER24
Protein Name	Ataxin-10
Gene Name	Atxn10
Organism	Rattus norvegicus (Rat).
Sequence Length	475
Subcellular Localization	Cytoplasm . Cytoplasm, perinuclear region.
Protein Description	Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis..
Protein Sequence	MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSTQAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEDSQSIVWVHAFPELFMSCLNHPDKKIVAYCSMILFTSLNSERMKDLEENLNIAINVIEAHQKHPESEWPFLIITDHFLKSPELVEAMYGKLSNQERVTLLDIMIAKIVGDEQLTKDDISIFLRHAELIANSFVDQCRNVLKLTSEPQTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVIDVLRVIHSVGKDSTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKVNELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDFIAKMEEQGLADASLLKKMGFEVEKSGDKLILKSNNDIPPP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AAPRMPPSRLSGIMV CCCCCCHHHCCCCCC	39.73	23984901
10	Methylation	APRMPPSRLSGIMVP CCCCCHHHCCCCCCC	38.35	-
12	Phosphorylation	RMPPSRLSGIMVPAP CCCHHHCCCCCCCCC	25.76	25403869
96	Phosphorylation	RNACIECSVNQNSIR HHHHHHCCCCCHHHC	16.00	27097102
101	Phosphorylation	ECSVNQNSIRNLDTI HCCCCCHHHCCCHHH	17.11	27097102
262	Ubiquitination	VGDEQLTKDDISIFL HCCCCCCHHHHHHHH	63.09	-
352	Phosphorylation	KDSTNIFSPSDSLKA CCCCCCCCCCHHCCC	21.50	28432305
354	Phosphorylation	STNIFSPSDSLKAEG CCCCCCCCHHCCCCC	38.34	28432305
356	Phosphorylation	NIFSPSDSLKAEGDI CCCCCCHHCCCCCCH	35.79	23984901
430	Phosphorylation	RNLTEDNSQNQDFIA HCCCCCCCCCHHHHH	42.71	28432305
438	Ubiquitination	QNQDFIAKMEEQGLA CCHHHHHHHHHCCCC	41.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATX10_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATX10_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATX10_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
OGT1_RAT	Ogt	physical	16714295

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATX10_RAT

Related Literatures of Post-Translational Modification