ATS6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATS6_HUMAN
• UniProt AC: Q9UKP5
• Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 6
• Gene Name: ADAMTS6
• Organism: Homo sapiens (Human).
• Sequence Length: 1117
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Sequence: MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEILWKTLTWILSL -CHHHHHHHHHHHHH	20.17	24043423
9	Phosphorylation	EILWKTLTWILSLIM HHHHHHHHHHHHHHH	18.72	24043423
13	Phosphorylation	KTLTWILSLIMASSE HHHHHHHHHHHHCCC	13.50	24043423
18	Phosphorylation	ILSLIMASSEFHSDH HHHHHHHCCCCCCCC	17.02	24043423
19	Phosphorylation	LSLIMASSEFHSDHR HHHHHHCCCCCCCCC	34.44	24043423
23	Phosphorylation	MASSEFHSDHRLSYS HHCCCCCCCCCCCCC	40.19	24043423
45	Phosphorylation	YLEHYQLTIPIRVDQ HHHHCCEEEEEEECC	14.80	46159373
99	N-linked_Glycosylation	YGKHFHLNLTLNTDF CCCEEEEEEEECCCC	23.55	UniProtKB CARBOHYD
165	Phosphorylation	IATEDEEYFIEPLKN EECCCCCEEEECCCC	14.07	68708797
172	N-linked_Glycosylation	YFIEPLKNTTEDSKH EEEECCCCCCCCCCC	60.97	UniProtKB CARBOHYD
222	N-linked_Glycosylation	SGKPWWLNDTSTVSY CCCCEECCCCCCEEE	36.47	UniProtKB CARBOHYD
234	N-linked_Glycosylation	VSYSLPINNTHIHHR EEEECCCCCCCCCCC	45.46	UniProtKB CARBOHYD
274 (in isoform 4)	Phosphorylation	-	7.26	26503514
277 (in isoform 4)	Phosphorylation	-	15.12	26503514
284	Acetylation	SVMNIVAKLYRDSSL HHHHHHHHHHCCCCH	34.85	7661983
451 (in isoform 3)	Phosphorylation	-	12.65	22210691
453 (in isoform 3)	Phosphorylation	-	13.75	22210691
454 (in isoform 3)	Phosphorylation	-	17.79	22210691
591	Phosphorylation	HCDSPAPSGGGKYCL CCCCCCCCCCCCCCC	52.77	22210691
724	N-linked_Glycosylation	DAIEGFFNDSLPRGG HHHHHHCCCCCCCCC	35.38	UniProtKB CARBOHYD
851 (in isoform 2)	Phosphorylation	-	28.73	30257219
956	N-linked_Glycosylation	VEKEPCNNQSCPPQW CCCCCCCCCCCCCCE	41.69	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATS6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATS6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATS6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ATS6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.