| UniProt ID | ATS1_MOUSE | |
|---|---|---|
| UniProt AC | P97857 | |
| Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 1 | |
| Gene Name | Adamts1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 968 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix. | |
| Protein Description | Cleaves aggrecan, a cartilage proteoglycan, at the '1691-Glu-|-Leu-1692' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity (By similarity). Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (By similarity).. | |
| Protein Sequence | MQPKVPLGSRKQKPCSDMGDVQRAARSRGSLSAHMLLLLLASITMLLCARGAHGRPTEEDEELVLPSLERAPGHDSTTTRLRLDAFGQQLHLKLQPDSGFLAPGFTLQTVGRSPGSEAQHLDPTGDLAHCFYSGTVNGDPGSAAALSLCEGVRGAFYLQGEEFFIQPAPGVATERLAPAVPEEESSARPQFHILRRRRRGSGGAKCGVMDDETLPTSDSRPESQNTRNQWPVRDPTPQDAGKPSGPGSIRKKRFVSSPRYVETMLVADQSMADFHGSGLKHYLLTLFSVAARFYKHPSIRNSISLVVVKILVIYEEQKGPEVTSNAALTLRNFCSWQKQHNSPSDRDPEHYDTAILFTRQDLCGSHTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKHCASLNGVSGDSHLMASMLSSLDHSQPWSPCSAYMVTSFLDNGHGECLMDKPQNPIKLPSDLPGTLYDANRQCQFTFGEESKHCPDAASTCTTLWCTGTSGGLLVCQTKHFPWADGTSCGEGKWCVSGKCVNKTDMKHFATPVHGSWGPWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEPTVEWTPKYAGVSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKMSGIVTSTRPGYHDIVTIPAGATNIEVKHRNQRGSRNNGSFLAIRAADGTYILNGNFTLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMVGHALRPKIKFTYFMKKKTESFNAIPTFSEWVIEEWGECSKTCGSGWQRRVVQCRDINGHPASECAKEVKPASTRPCADLPCPHWQVGDWSPCSKTCGKGYKKRTLKCVSHDGGVLSNESCDPLKKPKHYIDFCTLTQCS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | QPKVPLGSRKQKPCS CCCCCCCCCCCCCCC | 43.94 | 24719451 | |
| 9 | Phosphorylation | QPKVPLGSRKQKPCS CCCCCCCCCCCCCCC | 43.94 | 103260441 | |
| 257 | Phosphorylation | RKKRFVSSPRYVETM CCCCCCCCCCCEEEE | 14.22 | 24719451 | |
| 282 | Phosphorylation | HGSGLKHYLLTLFSV CCCCHHHHHHHHHHH | 11.21 | 28059163 | |
| 288 | Phosphorylation | HYLLTLFSVAARFYK HHHHHHHHHHHHHHC | 17.60 | 28059163 | |
| 298 | Phosphorylation | ARFYKHPSIRNSISL HHHHCCHHHHHCEEE | 33.62 | 24719451 | |
| 548 | N-linked_Glycosylation | CVSGKCVNKTDMKHF EECCEECCCCCCCCC | 51.48 | - | |
| 721 | N-linked_Glycosylation | KCGVCGGNGSTCKKM CCCCCCCCCHHCCHH | 26.90 | - | |
| 765 | N-linked_Glycosylation | NQRGSRNNGSFLAIR CCCCCCCCCCEEEEE | 46.50 | - | |
| 783 | N-linked_Glycosylation | GTYILNGNFTLSTLE CEEEECCCEEEEECC | 26.17 | - | |
| 946 | N-linked_Glycosylation | HDGGVLSNESCDPLK CCCCCCCCCCCCCCC | 40.83 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATS1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATS1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATS1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ATS1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
