ATR_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATR_CAEEL
• UniProt AC: Q22258
• Protein Name: Serine/threonine-protein kinase ATR
• Gene Name: atl-1 {ECO:0000312|WormBase:T06E4.3a}
• Organism: Caenorhabditis elegans.
• Sequence Length: 2531
• Subcellular Localization: Nucleus . Recruited to stalled replication forks by rpa-1-coated single-stranded DNA. Recruited to processed double-strand breaks in a rpa-1 and mre-11-dependent manner.
• Protein Description: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the checkpoint response to double-strand breaks (DSBs) after ionizing radiation (IR) to induce cell cycle arrest or apoptosis via the cep-1/p53 pathway. [PubMed: 12747829]
• Protein Sequence: MNIDKDVSALLCTAKKYVTQKEFNRQKMKFLLDDITKLLSKSFVSRIEQLDENEFMEKIMILQSITFTLHLITEKQELSSEEKIRLFQSVIASMCAFEDEELAKCFDRILSVLMISVTKQDPRETIYFLQGLLEVVKYCDVEPSSSLPQLITPEIASAISLGASGFFRYHLKWNIISTLFGENAGECVHFDELVLFWPHCRSQLEDKLKNDCSMTENCLRAGLTILKYKKLHNSILDQALFIDELFATFNSLTAKKSTNHMTFPKLLNEIQHFLQDHGKVLIMHKELRQKPVQWLIIYLELIDDANDKFGLLENFSLLLLDLSTNHDIHEFPARLCMTASEICMRRIKHSIQSTHTDCLADYLDILASLLKLARIQKLDIFQCFATEIEAHHSLNNPLWPRILRSLLSVQNPHCQQFCKKFVPSIDKLWITLLNGESSRATLNSLVIVTASCPFANNNDEGVKQIIPFLLIPCFQDFRDRVGSKWDNFRFIGLPKSEPSELINLERFTTVLERSTSESTKLRAVNCALQLEKKTGKYINLVAEMSLAVFSKSQTDRIANSFEPLILFLTDNLQLINDFITILIAKLCEKQEFYSELTILKYFKTLQKLFCLAANGRNSCKKCGEECFVDPDSKENVKIDYESLSGLIKGIVARRNTFSQELIREFLQTSRVMLLHVDSKGIASSFTSIIKALDIGFSENANAYFRVWELVCCRSEATVEKKLQMYIPLIGRSFALLGDDAALKVHGFLSNVLSARLSSTVKATLFASSFAHSVLKNCEIDWNVSYTWKTQFSQCLIKAPVGTCEEALQIMFKRYSTIFTRCFLNRLFFDASSAGAQKPSYDEHRIREITRCYLSHVLSDFNFPNQKITFNMIRPSLLYWSLLSSARGINSKLTLSVIDFICQEMSAASVSMSSISPNPSDIRIVMIQRKSLITETFAQLVQFLAFENNRNTTSFWKFCSDHCDFKDEDIRTVISSYRKQVFMHLLLVSAREFLNPRNPSMIVEQLRATYENIKKGEKFMISTAIETRNEGIEFLFIFRTYFTNDQYFLTREATAESFRILLQNMKQDFFDTNWYIILMTLRQIPLNLDSTQSSWISFIEQINYSILRSNIWRILTDISRIENNDILIEKVWNRLSYDMVIDKISTDAMIKRVFWLIPLEVEKRIDLKFEISKSRQIEDVLEFIRMFPQYPSVQFADNLASKIERKTVYKEELPKLIGSLSRILPQCHSKREQNKIIKILQKLPIICSDLPDHNFIRWDTRFKFFCEPRQLTQAVLEDCAGIVEVMTGTSKIEYVDRTMCEIYKFFNPNEASPEMKSTLDGIKNMYAKMICSQKPEPSMIEQKTIDELSLGGSRRESFSRWLTVIILKCAEMSEDAPLSSLASIAHVDDTRFLSKLAMRFILTVIHMERDSVTQWILSTFEEALTNTNHRRLTNSDRGPASFVFYVFDFIYSYSSSEELRKKKKIWEKVISFWKSMMSWTFKDENGHGQPLIVKVAETFGMEKRCILWLEMFMEQKRKTSTEIESETEAAYYFTLMNLYGRIHELNGVRGAYARLSRIQIDHVYGKISMREAFGDFNSAACFARMTGKGKPFNSTEAIQKLIDELNCLEYSQIERNEQEDYLNSLKTLSQWVNIDNDIGPSPHIFSRNIEYWATESTILKMIRNDERDEIVNNAIENAKSKVIERLSECAIGGSCSYEIATPFLVELQKLNEIVELKNVSNDELSAFNSDFWKNIQKRTDDSEQKISILEPILRVRRSMLDIRMQSMTGRDKENIRSRIVEVHLQSARIARLTGCFERAQLSLINAKKVLPFENKIVLEEAKLQLQTSDELNGMSLLDSIISKNFGDLHTIYTDTQQSVNLDVQKSAKLKIEHYQEETKNLFSSVQMLRISHMIKAGNTIGFDKVYHETTQLLQCFAHSGVMYEAAWLLDYLSNYKERSKHVLPLLKAYKEVAKYEKNQVLQARAVERMTSLWLSNTRKISTHISSVPKLPEGQISDLRQNIKSMNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPHQCMWQSAYLLRQNIASVKEKYMEVLTEVKRKAPCYVTLIDQYDYASGVFNTVSGKVESDDCKLSEKVDGLKTMFRDKKYDPKELVMNRRVDCDCKILSGIMVPVRSVIDESVHDTEIRDDGFEESCHLPDRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTSGEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVHTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADLPNLVADFPSNKRAPKDFDMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIELATSEEKLSEMYLGWMATL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of ATR_CAEEL !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATR_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATR_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATR_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of ATR_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.