ATP5H_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATP5H_RAT
• UniProt AC: P31399
• Protein Name: ATP synthase subunit d, mitochondrial
• Gene Name: Atp5h
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 161
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements..
• Protein Sequence: MAGRKLALKTIDWVSFVEIMPQNQKAIGNALKSWNETFHTRLASLSEKPPAIDWAYYRANVDKPGLVDDFKNKYNALKIPVPEDKYTALVDAEEKEDVKNCAQFVTGSQARVREYEKQLEKIKNMIPFDQMTIDDLNEVFPETKLDKRKYPYWPHQPIENL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGRKLALK ------CCCCHHHHH	26.88	-
10	Phosphorylation	GRKLALKTIDWVSFV CCHHHHHHCCEEEEE	25.64	23991683
15	Phosphorylation	LKTIDWVSFVEIMPQ HHHCCEEEEEEECCC	21.22	23991683
32	Acetylation	KAIGNALKSWNETFH HHHHHHHHHHHHHHH	51.52	22902405
33	Phosphorylation	AIGNALKSWNETFHT HHHHHHHHHHHHHHH	35.66	23991683
44	Phosphorylation	TFHTRLASLSEKPPA HHHHHHHHHCCCCCC	36.70	23991683
44	O-linked_Glycosylation	TFHTRLASLSEKPPA HHHHHHHHHCCCCCC	36.70	26446791
46	Phosphorylation	HTRLASLSEKPPAID HHHHHHHCCCCCCCC	40.87	23991683
48	Acetylation	RLASLSEKPPAIDWA HHHHHCCCCCCCCEE	53.58	22902405
63	Succinylation	YYRANVDKPGLVDDF EHHCCCCCCCCHHHH	36.38	26843850
63	Acetylation	YYRANVDKPGLVDDF EHHCCCCCCCCHHHH	36.38	22902405
71	Succinylation	PGLVDDFKNKYNALK CCCHHHHHHHCCCCC	60.57	26843850
71	Acetylation	PGLVDDFKNKYNALK CCCHHHHHHHCCCCC	60.57	22902405
73	Succinylation	LVDDFKNKYNALKIP CHHHHHHHCCCCCCC	40.24	26843850
73	Acetylation	LVDDFKNKYNALKIP CHHHHHHHCCCCCCC	40.24	22902405
78	Succinylation	KNKYNALKIPVPEDK HHHCCCCCCCCCCCC	42.42	-
78	Acetylation	KNKYNALKIPVPEDK HHHCCCCCCCCCCCC	42.42	22902405
85	Succinylation	KIPVPEDKYTALVDA CCCCCCCCCEEEECH	42.72	-
85	Acetylation	KIPVPEDKYTALVDA CCCCCCCCCEEEECH	42.72	22902405
95	Acetylation	ALVDAEEKEDVKNCA EEECHHHHHHHHHHH	51.20	22902405
95	Succinylation	ALVDAEEKEDVKNCA EEECHHHHHHHHHHH	51.20	26843850
99	Acetylation	AEEKEDVKNCAQFVT HHHHHHHHHHHHHHH	59.64	22902405
106	Phosphorylation	KNCAQFVTGSQARVR HHHHHHHHHHHHHHH	32.19	27097102
108	Phosphorylation	CAQFVTGSQARVREY HHHHHHHHHHHHHHH	15.99	27097102
117	Acetylation	ARVREYEKQLEKIKN HHHHHHHHHHHHHHH	60.32	25786129
117	Succinylation	ARVREYEKQLEKIKN HHHHHHHHHHHHHHH	60.32	26843850
121	Acetylation	EYEKQLEKIKNMIPF HHHHHHHHHHHCCCC	68.52	26302492
123	Acetylation	EKQLEKIKNMIPFDQ HHHHHHHHHCCCCCC	52.08	22902405
144	Succinylation	NEVFPETKLDKRKYP HHHCCCCCCCCCCCC	53.69	-
144	Acetylation	NEVFPETKLDKRKYP HHHCCCCCCCCCCCC	53.69	22902405
147	Acetylation	FPETKLDKRKYPYWP CCCCCCCCCCCCCCC	62.31	26302492
149	Acetylation	ETKLDKRKYPYWPHQ CCCCCCCCCCCCCCC	57.21	22902405
149	Succinylation	ETKLDKRKYPYWPHQ CCCCCCCCCCCCCCC	57.21	26843850
152	Phosphorylation	LDKRKYPYWPHQPIE CCCCCCCCCCCCCCC	28.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATP5H_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATP5H_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATP5H_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ATP5H_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.