dbPTM

ATF7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATF7_MOUSE
UniProt AC	Q8R0S1
Protein Name	Cyclic AMP-dependent transcription factor ATF-7
Gene Name	Atf7
Organism	Mus musculus (Mouse).
Sequence Length	413
Subcellular Localization	Nucleus . Nucleus, nucleoplasm. Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear peiphery (By similarity)..
Protein Description	Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family (By similarity)..
Protein Sequence	MGDDRPFVCSAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKASDDDEKKGAAGPLDMSLPSTPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTTKPVVISTPTPTIVRPGSLPLHLGYDPLHPTLPSPTSVITQAPPSNRQIGSPTGSLPLVMHLANGQTMPMLPGPPVQMPSVISLARPVSMVPNIPGIPGPPVNNSGSISPSGHPMPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARPEQNQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGYLGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	LKFGPARTDSVIIAD EEECCCCCCCEEEEC	34.43	27087446
44	Phosphorylation	FGPARTDSVIIADQT ECCCCCCCEEEECCC	18.01	23684622
51	Phosphorylation	SVIIADQTPTPTRFL CEEEECCCCCCCHHH	29.67	25521595
53	Phosphorylation	IIADQTPTPTRFLKN EEECCCCCCCHHHHC	40.45	25521595
55	Phosphorylation	ADQTPTPTRFLKNCE ECCCCCCCHHHHCHH	36.21	27087446
72	Phosphorylation	GLFNELASSFEHEFK CHHHHHHHHHHHHHH	48.46	26643407
73	Phosphorylation	LFNELASSFEHEFKK HHHHHHHHHHHHHHH	29.10	29514104
82	Phosphorylation	EHEFKKASDDDEKKG HHHHHHCCCCCCCCC	50.91	-
97	Phosphorylation	AAGPLDMSLPSTPDI CCCCCCCCCCCCCCC	36.47	27087446
100	Phosphorylation	PLDMSLPSTPDIKIK CCCCCCCCCCCCCCC	58.84	21082442
101	Phosphorylation	LDMSLPSTPDIKIKE CCCCCCCCCCCCCCC	24.04	27087446
116	Phosphorylation	EEPVEVDSSPPDSPA CCCCCCCCCCCCCCC	50.34	26643407
117	Phosphorylation	EPVEVDSSPPDSPAS CCCCCCCCCCCCCCC	35.67	26643407
121	Phosphorylation	VDSSPPDSPASSPCS CCCCCCCCCCCCCCC	28.30	26643407
124	Phosphorylation	SPPDSPASSPCSPPL CCCCCCCCCCCCCCC	37.89	26643407
125	Phosphorylation	PPDSPASSPCSPPLK CCCCCCCCCCCCCCC	31.84	26643407
128	Phosphorylation	SPASSPCSPPLKEKE CCCCCCCCCCCCCCC	32.70	26643407
137	Phosphorylation	PLKEKEVTTKPVVIS CCCCCCCCCCCEEEE	30.14	25367039
138	Phosphorylation	LKEKEVTTKPVVIST CCCCCCCCCCEEEEC	38.23	25367039
144	Phosphorylation	TTKPVVISTPTPTIV CCCCEEEECCCCCEE	19.41	25367039
168	Phosphorylation	GYDPLHPTLPSPTSV CCCCCCCCCCCCCCE	40.32	25367039
171	Phosphorylation	PLHPTLPSPTSVITQ CCCCCCCCCCCEEEE	43.87	25367039
173	Phosphorylation	HPTLPSPTSVITQAP CCCCCCCCCEEEECC	39.71	25367039
174	Phosphorylation	PTLPSPTSVITQAPP CCCCCCCCEEEECCC	18.20	25367039
226	Phosphorylation	ISLARPVSMVPNIPG HHHCCCCCCCCCCCC	19.42	25777480
242	Phosphorylation	PGPPVNNSGSISPSG CCCCCCCCCCCCCCC	28.81	26643407
244	Phosphorylation	PPVNNSGSISPSGHP CCCCCCCCCCCCCCC	21.51	26643407
246	Phosphorylation	VNNSGSISPSGHPMP CCCCCCCCCCCCCCC	18.08	26643407
248	Phosphorylation	NSGSISPSGHPMPSE CCCCCCCCCCCCCCH	42.83	25777480
254	Phosphorylation	PSGHPMPSEAKMRLK CCCCCCCCHHHHHHH	43.89	25777480
326	Phosphorylation	TGGRRRRTVDEDPDE CCCCCCCCCCCCHHH	30.42	25521595
358	Phosphorylation	QKRKLWVSSLEKKAE HHHHHHHHHHHHHHH	20.02	25338131
359	Phosphorylation	KRKLWVSSLEKKAEE HHHHHHHHHHHHHHH	30.81	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
51	T	Phosphorylation	Kinase	MAPK11	Q9WUI1	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
51	T	Phosphorylation	29490055
On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51.
53	T	Phosphorylation	29490055
On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATF7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MCAF1_MOUSE	Atf7ip	physical	10777215

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATF7_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51 AND THR-53, AND MASSSPECTROMETRY.	17242355 [Abstract]

show

show