AT8A1_HUMAN - dbPTM
AT8A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT8A1_HUMAN
UniProt AC Q9Y2Q0
Protein Name Phospholipid-transporting ATPase IA
Gene Name ATP8A1
Organism Homo sapiens (Human).
Sequence Length 1164
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane
Multi-pass membrane protein . Cytoplasmic granule . Cell membrane . Endoplasmic reticulum . Golgi apparatus . Exit from the endoplasmic reticulum requires the presence of TMEM30A,
Protein Description Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells..
Protein Sequence MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPTMRRTVSE
-----CCCHHHHHHH		34.8624043423
7Phosphorylation-MPTMRRTVSEIRSR
-CCCHHHHHHHHHHH		20.3029691806
9PhosphorylationPTMRRTVSEIRSRAE
CCHHHHHHHHHHHHC		27.0529691806
20UbiquitinationSRAEGYEKTDDVSEK
HHHCCCCCCCCCCCC		49.0932142685
21PhosphorylationRAEGYEKTDDVSEKT
HHCCCCCCCCCCCCC		26.0328787133
25PhosphorylationYEKTDDVSEKTSLAD
CCCCCCCCCCCCCCC		40.1322617229
27UbiquitinationKTDDVSEKTSLADQE
CCCCCCCCCCCCCHH		35.5932142685
27 (in isoform 2)Ubiquitination-35.59-
28PhosphorylationTDDVSEKTSLADQEE
CCCCCCCCCCCCHHH		25.5623401153
29PhosphorylationDDVSEKTSLADQEEV
CCCCCCCCCCCHHHH		32.4023401153
164 (in isoform 3)Phosphorylation-38.21-
207UbiquitinationLPATSDIKDVDSLMR
CCCCCCCCCHHHHHH		57.6032142685
216PhosphorylationVDSLMRISGRIECES
HHHHHHHCCCEEECC		16.2024719451
246UbiquitinationGHGTVPLGADQILLR
CCCCCCCCHHEEEEC		22.4922817900
274PhosphorylationVVYTGHDTKLMQNST
EEEECCCCHHCCCCC		22.02-
294PhosphorylationLSNVERITNVQILIL
CCCHHHHHHHHHHHH		35.24-
309PhosphorylationFCILIAMSLVCSVGS
HHHHHHHHHHHHHHH		14.50-
324PhosphorylationAIWNRRHSGKDWYLN
HHHCCCCCCCCEEEE		45.81-
410UbiquitinationVKYIFSDKTGTLTCN
CEEEEECCCCEEEEE		47.8922817900
415UbiquitinationSDKTGTLTCNVMQFK
ECCCCEEEEEEEEEE		11.2421890473
425UbiquitinationVMQFKKCTIAGVAYG
EEEEEECEEEEEEEC		23.8122817900
430UbiquitinationKCTIAGVAYGHVPEP
ECEEEEEEECCCCCH		12.0421890473
443PhosphorylationEPEDYGCSPDEWQNS
CHHHCCCCHHHHHCC		30.9024076635
501PhosphorylationREGDKIIYQAASPDE
CCCCEEEEECCCCCC		8.7927642862
505PhosphorylationKIIYQAASPDEGALV
EEEEECCCCCCCHHH		35.5827642862
564PhosphorylationSVIVRTPSGKLRLYC
EEEEECCCCCEEEEE		48.20-
572UbiquitinationGKLRLYCKGADTVIY
CCEEEEECCCCEEEE		43.5132142685
574UbiquitinationLRLYCKGADTVIYDR
EEEEECCCCEEEEEH		8.5222817900
579UbiquitinationKGADTVIYDRLAETS
CCCCEEEEEHHHCCC		7.2321890473
579UbiquitinationKGADTVIYDRLAETS
CCCCEEEEEHHHCCC		7.2321890473
579UbiquitinationKGADTVIYDRLAETS
CCCCEEEEEHHHCCC		7.2321890473
579UbiquitinationKGADTVIYDRLAETS
CCCCEEEEEHHHCCC		7.2321890473
579UbiquitinationKGADTVIYDRLAETS
CCCCEEEEEHHHCCC		7.2321890473
579 (in isoform 2)Ubiquitination-7.2321890473
587UbiquitinationDRLAETSKYKEITLK
EHHHCCCCCCCHHHH		68.6932142685
589UbiquitinationLAETSKYKEITLKHL
HHCCCCCCCHHHHHH		46.5122817900
594UbiquitinationKYKEITLKHLEQFAT
CCCCHHHHHHHHHHH		37.1821890473
594 (in isoform 1)Ubiquitination-37.1821890473
601PhosphorylationKHLEQFATEGLRTLC
HHHHHHHHHHHHHHH		31.6923403867
606PhosphorylationFATEGLRTLCFAVAE
HHHHHHHHHHHHHHH		32.6823403867
617PhosphorylationAVAEISESDFQEWRA
HHHHCCHHHHHHHHH		36.6123403867
624UbiquitinationSDFQEWRAVYQRAST
HHHHHHHHHHHHHCH		12.8732142685
639UbiquitinationSVQNRLLKLEESYEL
HHHHHHHHHHHHHHH		59.4532142685
719PhosphorylationNEGSLDGTRETLSRH
ECCCCCCHHHHHHHH		25.6223403867
738UbiquitinationGDALRKENDFALIID
HHHHHHCCCEEEEEC		53.3822817900
743UbiquitinationKENDFALIIDGKTLK
HCCCEEEEECCEEHH		2.1221890473
748PhosphorylationALIIDGKTLKYALTF
EEEECCEEHHHHHHH		33.73-
754PhosphorylationKTLKYALTFGVRQYF
EEHHHHHHHCHHHHH		15.35-
760UbiquitinationLTFGVRQYFLDLALS
HHHCHHHHHHHHHHH		8.7822817900
765UbiquitinationRQYFLDLALSCKAVI
HHHHHHHHHHCCEEE		9.3321890473
811PhosphorylationNDVSMIQTAHVGVGI
CCCEEEEEEEEECCC		14.06-
839PhosphorylationYSIAQFKYLKNLLMI
CCHHHHHHHHHHHHH		24.97-
902UbiquitinationLYNVMFTAMPPLTLG
HHHHHHHCCCCCCHH		9.3822817900
907UbiquitinationFTAMPPLTLGIFERS
HHCCCCCCHHHHHHH		28.8121890473
907UbiquitinationFTAMPPLTLGIFERS
HHCCCCCCHHHHHHH		28.8121890473
907UbiquitinationFTAMPPLTLGIFERS
HHCCCCCCHHHHHHH		28.8121890473
907UbiquitinationFTAMPPLTLGIFERS
HHCCCCCCHHHHHHH		28.8121890473
907UbiquitinationFTAMPPLTLGIFERS
HHCCCCCCHHHHHHH		28.8122817900
907 (in isoform 2)Ubiquitination-28.8121890473
909UbiquitinationAMPPLTLGIFERSCR
CCCCCCHHHHHHHHC		19.8022817900
911UbiquitinationPPLTLGIFERSCRKE
CCCCHHHHHHHHCHH		6.3923503661
914UbiquitinationTLGIFERSCRKENML
CHHHHHHHHCHHHCC		15.8621890473
917UbiquitinationIFERSCRKENMLKYP
HHHHHHCHHHCCCCH		58.7422817900
922UbiquitinationCRKENMLKYPELYKT
HCHHHCCCCHHHHHH		48.2532142685
922 (in isoform 1)Ubiquitination-48.2521890473
924UbiquitinationKENMLKYPELYKTSQ
HHHCCCCHHHHHHCC		24.4322817900
927PhosphorylationMLKYPELYKTSQNAL
CCCCHHHHHHCCHHC		15.5729759185
929PhosphorylationKYPELYKTSQNALDF
CCHHHHHHCCHHCCC		23.2222210691
929UbiquitinationKYPELYKTSQNALDF
CCHHHHHHCCHHCCC		23.2221890473
930PhosphorylationYPELYKTSQNALDFN
CHHHHHHCCHHCCCC		19.7922210691
932UbiquitinationELYKTSQNALDFNTK
HHHHHCCHHCCCCCH		42.0921890473
933UbiquitinationLYKTSQNALDFNTKV
HHHHCCHHCCCCCHH		10.8123503661
936UbiquitinationTSQNALDFNTKVFWV
HCCHHCCCCCHHHHH		15.0922817900
937UbiquitinationSQNALDFNTKVFWVH
CCHHCCCCCHHHHHH		38.3622817900
944UbiquitinationNTKVFWVHCLNGLFH
CCHHHHHHHHHHHHH		10.8421890473
954UbiquitinationNGLFHSVILFWFPLK
HHHHHHHHHHHHHHH		2.6921890473
958UbiquitinationHSVILFWFPLKALQY
HHHHHHHHHHHHHHC		3.8822817900
959UbiquitinationSVILFWFPLKALQYG
HHHHHHHHHHHHHCC		24.4422817900
979UbiquitinationGKTSDYLLLGNFVYT
CCCCCEEEECCHHCH		4.7223503661
1001UbiquitinationLKAGLETSYWTWFSH
HHHCCCCCHHHHHHH		14.8623503661
1075UbiquitinationVYKVIKRTAFKTLVD
HHHHHHHHHHHHHHH		31.2930230243
1075 (in isoform 2)Ubiquitination-31.29-
1078UbiquitinationVIKRTAFKTLVDEVQ
HHHHHHHHHHHHHHH		38.19-
1082UbiquitinationTAFKTLVDEVQELEA
HHHHHHHHHHHHHHH		54.1623503661
1086UbiquitinationTLVDEVQELEAKSQD
HHHHHHHHHHHHHCC		54.4721890473
1086UbiquitinationTLVDEVQELEAKSQD
HHHHHHHHHHHHHCC		54.4721890473
1086UbiquitinationTLVDEVQELEAKSQD
HHHHHHHHHHHHHCC		54.4721890473
1086UbiquitinationTLVDEVQELEAKSQD
HHHHHHHHHHHHHCC		54.4721890473
1086UbiquitinationTLVDEVQELEAKSQD
HHHHHHHHHHHHHCC		54.4732142685
1086 (in isoform 2)Ubiquitination-54.4721890473
1087 (in isoform 2)O-linked_Glycosylation-4.3021740066
1089 (in isoform 2)O-linked_Glycosylation-29.4421740066
1090UbiquitinationEVQELEAKSQDPGAV
HHHHHHHHHCCCCCE		39.0030230243
1093UbiquitinationELEAKSQDPGAVVLG
HHHHHHCCCCCEEEC		51.1721890473
1096UbiquitinationAKSQDPGAVVLGKSL
HHHCCCCCEEECCCH		8.1421890473
1096UbiquitinationAKSQDPGAVVLGKSL
HHHCCCCCEEECCCH		8.1421890473
1096UbiquitinationAKSQDPGAVVLGKSL
HHHCCCCCEEECCCH		8.1421890473
1096UbiquitinationAKSQDPGAVVLGKSL
HHHCCCCCEEECCCH		8.1421890473
1096UbiquitinationAKSQDPGAVVLGKSL
HHHCCCCCEEECCCH		8.1421890473
1096 (in isoform 2)Ubiquitination-8.1421890473
1097UbiquitinationKSQDPGAVVLGKSLT
HHCCCCCEEECCCHH		4.5323503661
1100UbiquitinationDPGAVVLGKSLTERA
CCCCEEECCCHHHHH		13.0922817900
1101UbiquitinationPGAVVLGKSLTERAQ
CCCEEECCCHHHHHH		37.8232142685
1101 (in isoform 1)Ubiquitination-37.8221890473
1103UbiquitinationAVVLGKSLTERAQLL
CEEECCCHHHHHHHH		7.0321890473
1107UbiquitinationGKSLTERAQLLKNVF
CCCHHHHHHHHHHHH		9.7222817900
1108UbiquitinationKSLTERAQLLKNVFK
CCHHHHHHHHHHHHH		54.2521890473
1111PhosphorylationTERAQLLKNVFKKNH
HHHHHHHHHHHHHCC		60.7132142685
1111UbiquitinationTERAQLLKNVFKKNH
HHHHHHHHHHHHHCC		60.7122817900
1111 (in isoform 1)Ubiquitination-60.7121890473
1115UbiquitinationQLLKNVFKKNHVNLY
HHHHHHHHHCCCCCC		48.6722817900
1116UbiquitinationLLKNVFKKNHVNLYR
HHHHHHHHCCCCCCC		40.6022817900
1118UbiquitinationKNVFKKNHVNLYRSE
HHHHHHCCCCCCCCH		20.7921890473
1122UbiquitinationKKNHVNLYRSESLQQ
HHCCCCCCCCHHHHH		13.5922817900
1123UbiquitinationKNHVNLYRSESLQQN
HCCCCCCCCHHHHHH		36.7922817900
1124PhosphorylationNHVNLYRSESLQQNL
CCCCCCCCHHHHHHH		20.2728450419
1126PhosphorylationVNLYRSESLQQNLLH
CCCCCCHHHHHHHHC		32.5028348404
1135PhosphorylationQQNLLHGYAFSQDEN
HHHHHCCCCCCCCCC		8.1728450419
1138PhosphorylationLLHGYAFSQDENGIV
HHCCCCCCCCCCCEE		28.6628450419
1143UbiquitinationAFSQDENGIVSQSEV
CCCCCCCCEECHHHH		21.4532142685
1143 (in isoform 2)Ubiquitination-21.45-
1150UbiquitinationGIVSQSEVIRAYDTT
CEECHHHHHHHHCCC		4.3223503661
1158UbiquitinationIRAYDTTKQRPDEW-
HHHHCCCCCCCCCC-		46.5332142685
1165UbiquitinationKQRPDEW--------
CCCCCCC--------		23503661
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AT8A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT8A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT8A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CC50A_HUMANTMEM30Aphysical
21914794
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00144Phosphatidylserine
Regulatory Network of AT8A1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; THR-28 AND SER-29,AND MASS SPECTROMETRY.

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