AT5G2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT5G2_RAT
• UniProt AC: Q06646
• Protein Name: ATP synthase F(0) complex subunit C2, mitochondrial {ECO:0000305}
• Gene Name: Atp5mc2 {ECO:0000312|RGD:620051}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 141
• Subcellular Localization: Mitochondrion membrane; Multi-pass membrane protein.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element..
• Protein Sequence: MYACSKFVSTRSLIRSTSQLLSRPLSAVELKRPQMPTDEGLSCLAVRRPLTSLIPSRSFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	TSLIPSRSFQTSAIS HHHCCCCCCCCCCCC	26.50	18779572
70	Phosphorylation	AISRDIDTAAKFIGA CCCCCHHHHHHHHCC	28.93	23991683
109	Methylation	YARNPSLKQQLFSYA HCCCHHHHHHHHHHH	40.09	30530489

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT5G2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
109	K	Methylation	Trimethylated by ATPSCKMT at Lys-109.	30530489

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT5G2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AT5G2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.