AT2B4_RAT - dbPTM
AT2B4_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2B4_RAT
UniProt AC Q64542
Protein Name Plasma membrane calcium-transporting ATPase 4 {ECO:0000305}
Gene Name Atp2b4 {ECO:0000312|RGD:621305}
Organism Rattus norvegicus (Rat).
Sequence Length 1203
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cell projection, cilium, flagellum membrane
Multi-pass membrane protein .
Protein Description Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (By similarity). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity)..
Protein Sequence MTNPSGHNLPANSVAESYEGEFGCTLMDLRKLMELRAADAVTQISAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGGENEICGHIVSNPEEDEEGETGWIEGAAILASVIIVVFVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGANEEEDDEKKKKGKKQGVSENRNKAKTQDGVALEIQPLNSQEGLDSEEKEKKASKGPKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRRAWLPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPKPDDLPPNVLDLIVNSICINSAYTSKILPPEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFKTKDRDNMVRNVIEPMASEGLRTIGIAYRDFDGEEPSWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKGIIDSNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPLNSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQWMWCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGSDKEEISKDAEGLEEIDHAEMELRRGQILWVRGLNRIQTQIRVVKVFHSFRDVIHKSKNQVSIHSFMTQPEYAADDEMSQSFLNQEESPSLASKSRITKRLSDAETVSQNNTNNNAVDCHQVQIVASHPNSPLQSQETPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationGHNLPANSVAESYEG
CCCCCCCCCHHHHCC		25.47-
59 (in isoform 2)Ubiquitination-41.21-
75 (in isoform 2)Ubiquitination-50.55-
247AcetylationTGESDHVKKTLDKDP
CCCCHHHHHHCCCCC		36.308264533
252 (in isoform 2)Ubiquitination-67.83-
328PhosphorylationLEIQPLNSQEGLDSE
EEEEECCCCCCCCHH		36.9730240740
334PhosphorylationNSQEGLDSEEKEKKA
CCCCCCCHHHHHHHH		53.3425403869
337 (in isoform 2)Ubiquitination-71.44-
561AcetylationRSEMPEEKLFKVYTF
HHCCCHHHHEEEEEH		58.5222902405
561 (in isoform 2)Ubiquitination-58.52-
570PhosphorylationFKVYTFNSVRKSMST
EEEEEHHHHHHHHCE		21.0725403869
607 (in isoform 2)Ubiquitination-55.05-
607AcetylationKCDRILNKEGGIVPF
HCHHHHCCCCCEECC		55.0522902405
725UbiquitinationDFLCLEGKEFNRLIR
CEEEECCHHHHHHHH		50.16-
725AcetylationDFLCLEGKEFNRLIR
CEEEECCHHHHHHHH		50.16134755
735 (in isoform 2)Ubiquitination-65.01-
742 (in isoform 2)Ubiquitination-62.77-
745 (in isoform 2)Ubiquitination-57.55-
756PhosphorylationRLRVLARSSPTDKHT
HHHHHHCCCCCCHHH		34.7525403869
757PhosphorylationLRVLARSSPTDKHTL
HHHHHCCCCCCHHHH		26.6825403869
759PhosphorylationVLARSSPTDKHTLVK
HHHCCCCCCHHHHHH		60.6825403869
794UbiquitinationTNDGPALKKADVGFA
CCCCHHHHHCCCEEE		48.28-
795UbiquitinationNDGPALKKADVGFAM
CCCHHHHHCCCEEEH		51.15-
1055AcetylationAIPTKSLKFLKEAGH
HCCCCHHHHHHHCCC		56.6022902405
1064PhosphorylationLKEAGHGSDKEEISK
HHHCCCCCCHHHHCC		39.5725403869
1070PhosphorylationGSDKEEISKDAEGLE
CCCHHHHCCCCCCHH		27.9722673903
1102PhosphorylationRGLNRIQTQIRVVKV
ECCCHHHHHHHHHHH		24.48-
1103 (in isoform 3)Phosphorylation-12.7125403869
1112PhosphorylationRVVKVFHSFRDVIHK
HHHHHHHHHHHHHHH		15.5428432305
1114 (in isoform 3)Phosphorylation-40.0625403869
1115 (in isoform 2)Phosphorylation-41.5325403869
1124 (in isoform 3)Phosphorylation-8.9623800682
1125 (in isoform 3)Phosphorylation-12.5723800682
1126 (in isoform 2)Phosphorylation-3.1125403869
1132 (in isoform 3)Phosphorylation-19.6223800682
1135PhosphorylationSFMTQPEYAADDEMS
EECCCHHHCCCHHHH		17.4823984901
1135 (in isoform 3)Phosphorylation-17.4828551015
1136 (in isoform 3)Phosphorylation-11.6228551015
1136 (in isoform 2)Phosphorylation-11.6223800682
1137 (in isoform 2)Phosphorylation-24.7223800682
1138 (in isoform 3)Phosphorylation-44.2028551015
1139 (in isoform 3)Phosphorylation-49.0928551015
1140 (in isoform 3)Phosphorylation-41.0828551015
1141 (in isoform 3)Phosphorylation-5.9328551015
1142PhosphorylationYAADDEMSQSFLNQE
HCCCHHHHHHHHCCC		22.1823984901
1144 (in isoform 2)Phosphorylation-25.1323800682
1144 (in isoform 3)Phosphorylation-25.1325403869
1144PhosphorylationADDEMSQSFLNQEES
CCHHHHHHHHCCCCC		25.1323984901
1147 (in isoform 2)Phosphorylation-45.2528551015
1148 (in isoform 2)Phosphorylation-58.9628551015
1150 (in isoform 2)Phosphorylation-59.1828551015
1151PhosphorylationSFLNQEESPSLASKS
HHHCCCCCCCHHCHH		21.0227097102
1151 (in isoform 2)Phosphorylation-21.0228551015
1152 (in isoform 2)Phosphorylation-36.3228551015
1153 (in isoform 2)Phosphorylation-45.9428551015
1153PhosphorylationLNQEESPSLASKSRI
HCCCCCCCHHCHHHH		45.9423984901
1156 (in isoform 2)Phosphorylation-36.1425403869
1156PhosphorylationEESPSLASKSRITKR
CCCCCHHCHHHHHHH		36.1423984901
1165PhosphorylationSRITKRLSDAETVSQ
HHHHHHHCHHHHHCC		38.5226437020
1169PhosphorylationKRLSDAETVSQNNTN
HHHCHHHHHCCCCCC		27.4626437020
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1102TPhosphorylationKinasePKC-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2B4_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2B4_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AT2B4_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT2B4_RAT

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Related Literatures of Post-Translational Modification

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