AT2B2_RAT - dbPTM
AT2B2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2B2_RAT
UniProt AC P11506
Protein Name Plasma membrane calcium-transporting ATPase 2
Gene Name Atp2b2
Organism Rattus norvegicus (Rat).
Sequence Length 1243
Subcellular Localization Cell junction, synapse . Cell membrane
Multi-pass membrane protein .
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell..
Protein Sequence MGDMTNSDFYSKNQRNESSHGGEFGCSMEELRSLMELRGTEAVVKIKETYGDTESICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGESNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQIKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAPANAAGSANASLVNGKMQDGSADSSQSKAKQQDGAAAMEMQPLKSAEGGDADDKKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLTECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINAKTLELLVNAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLRQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKMPDESFRMYSKGASEIVLKKCCKILSGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12UbiquitinationTNSDFYSKNQRNESS
CHHHHHCCCCCCCCC		45.80-
18PhosphorylationSKNQRNESSHGGEFG
CCCCCCCCCCCCCCC		31.0527097102
19PhosphorylationKNQRNESSHGGEFGC
CCCCCCCCCCCCCCC		21.7027097102
27PhosphorylationHGGEFGCSMEELRSL
CCCCCCCCHHHHHHH		29.6125403869
33PhosphorylationCSMEELRSLMELRGT
CCHHHHHHHHHHHCC		44.7022673903
45UbiquitinationRGTEAVVKIKETYGD
HCCEEEEEEEHHHCC		41.27-
61UbiquitinationESICRRLKTSPVEGL
HHHHHHHCCCCCCCC		45.18-
77AcetylationGTAPDLEKRKQIFGQ
CCCCCHHHHHHHHCC		72.6722902405
77UbiquitinationGTAPDLEKRKQIFGQ
CCCCCHHHHHHHHCC		72.67-
191AcetylationSRIEQEQKFTVVRAG
HHHHHHCCEEEEECC		42.1022902405
191UbiquitinationSRIEQEQKFTVVRAG
HHHHHHCCEEEEECC		42.10-
254AcetylationQVRKSVDKDPMLLSG
HHHHHCCCCCCCCCC		62.6722902405
254UbiquitinationQVRKSVDKDPMLLSG
HHHHHCCCCCCCCCC		62.67-
349UbiquitinationDSSQSKAKQQDGAAA
CCHHHHHHHHCCCHH		52.83-
363UbiquitinationAMEMQPLKSAEGGDA
HHHCCCCCCCCCCCC		55.06-
364PhosphorylationMEMQPLKSAEGGDAD
HHCCCCCCCCCCCCC		38.96-
487S-nitrosocysteineLVRHLDACETMGNAT
HHHHHHHHHHCCCCE		4.46-
487S-nitrosylationLVRHLDACETMGNAT
HHHHHHHHHHCCCCE		4.4622178444
497S-nitrosocysteineMGNATAICSDKTGTL
CCCCEEEECCCCCCE		3.90-
497S-nitrosylationMGNATAICSDKTGTL
CCCCEEEECCCCCCE		3.9022178444
522UbiquitinationYVGDVHYKEIPDPSS
EECCEECCCCCCHHH		34.00-
557UbiquitinationTKILPPEKEGALPRQ
CCCCCCCCCCCCCCC		68.19-
571S-nitrosocysteineQVGNKTECGLLGFVL
CCCCCCCCCHHHHHH		5.87-
571S-nitrosylationQVGNKTECGLLGFVL
CCCCCCCCCHHHHHH		5.8722178444
595AcetylationRSQMPEEKLYKVYTF
HHCCCHHHHHEEEEH		56.2922902405
595UbiquitinationRSQMPEEKLYKVYTF
HHCCCHHHHHEEEEH		56.29-
598AcetylationMPEEKLYKVYTFNSV
CCHHHHHEEEEHHHH		38.92-
604PhosphorylationYKVYTFNSVRKSMST
HEEEEHHHHCHHHCC		21.0725403869
633AcetylationGASEIVLKKCCKILS
CCHHHHHHHHHHHHC		32.6322902405
718DimethylationPEVPEAIRKCQRAGI
CCHHHHHHHHHHCCC		40.52-
718MethylationPEVPEAIRKCQRAGI
CCHHHHHHHHHHCCC		40.52-
770AcetylationNRRIRNEKGEIEQER
HHHHHCCCCCCCHHH		66.457768361
770UbiquitinationNRRIRNEKGEIEQER
HHHHHCCCCCCCHHH		66.45-
780AcetylationIEQERIDKIWPKLRV
CCHHHHHHHHHHHHH		44.287768375
780UbiquitinationIEQERIDKIWPKLRV
CCHHHHHHHHHHHHH		44.28-
784AcetylationRIDKIWPKLRVLARS
HHHHHHHHHHHHHCC		33.65-
791PhosphorylationKLRVLARSSPTDKHT
HHHHHHCCCCCCHHH		34.7525403869
792PhosphorylationLRVLARSSPTDKHTL
HHHHHCCCCCCHHHH		26.6825403869
794PhosphorylationVLARSSPTDKHTLVK
HHHCCCCCCHHHHHH		60.6825403869
801AcetylationTDKHTLVKGIIDSTH
CCHHHHHHHHHCCCC		47.7222902405
829UbiquitinationTNDGPALKKADVGFA
CCCCHHHHHCCCEEE		48.28-
830UbiquitinationNDGPALKKADVGFAM
CCCHHHHHCCCEEEH		51.15-
944UbiquitinationRKPYGRNKPLISRTM
CCCCCCCCCCCCHHH		39.58-
1101UbiquitinationEAGRLTQKEEIPEEE
HHCCCCCCHHCCHHH		52.67-
1107 (in isoform 12)Phosphorylation-63.5322673903
1107 (in isoform 5)Phosphorylation-63.5322673903
1107 (in isoform 8)Phosphorylation-63.5322673903
1116 (in isoform 12)Phosphorylation-2.73-
1116 (in isoform 5)Phosphorylation-2.73-
1116 (in isoform 8)Phosphorylation-2.7328551015
1117 (in isoform 12)Phosphorylation-37.92-
1117 (in isoform 5)Phosphorylation-37.92-
1117 (in isoform 8)Phosphorylation-37.9230240740
1119 (in isoform 8)Phosphorylation-17.5028551015
1120 (in isoform 8)Phosphorylation-43.1828551015
1121 (in isoform 10)Phosphorylation-49.3722673903
1121 (in isoform 3)Phosphorylation-49.3722673903
1121 (in isoform 6)Phosphorylation-49.3722673903
1122 (in isoform 8)Phosphorylation-37.8328551015
1127 (in isoform 8)Phosphorylation-26.2828551015
1129 (in isoform 8)Phosphorylation-2.4528551015
1130 (in isoform 10)Phosphorylation-5.19-
1130 (in isoform 3)Phosphorylation-5.19-
1130 (in isoform 6)Phosphorylation-5.1928551015
1130 (in isoform 8)Phosphorylation-5.1930240740
1131 (in isoform 10)Phosphorylation-3.88-
1131 (in isoform 3)Phosphorylation-3.88-
1131 (in isoform 6)Phosphorylation-3.8830240740
1132 (in isoform 8)Phosphorylation-36.7928551015
1133 (in isoform 6)Phosphorylation-20.1728551015
1134 (in isoform 6)Phosphorylation-3.2028551015
1135 (in isoform 5)Phosphorylation-41.6628551015
1136 (in isoform 6)Phosphorylation-27.6828551015
1137 (in isoform 5)Phosphorylation-5.1728551015
1138 (in isoform 11)Phosphorylation-24.9022673903
1138 (in isoform 4)Phosphorylation-24.9022673903
1138 (in isoform 7)Phosphorylation-24.9022673903
1139PhosphorylationRGLNRIQTQIRVVKA
ECCCHHHHHHHHHHH		24.48-
1141 (in isoform 5)Phosphorylation-4.0228551015
1141 (in isoform 6)Phosphorylation-4.0228551015
1142 (in isoform 12)Phosphorylation-19.8430240740
1142 (in isoform 5)Phosphorylation-19.8428551015
1143 (in isoform 6)Phosphorylation-5.7528551015
1144 (in isoform 5)Phosphorylation-2.3828551015
1144 (in isoform 6)Phosphorylation-2.3830240740
1145 (in isoform 5)Phosphorylation-38.6628551015
1146 (in isoform 6)Phosphorylation-8.0928551015
1147 (in isoform 11)Phosphorylation-6.88-
1147 (in isoform 4)Phosphorylation-6.88-
1147 (in isoform 7)Phosphorylation-6.8828551015
1148 (in isoform 11)Phosphorylation-30.14-
1148 (in isoform 4)Phosphorylation-30.14-
1148 (in isoform 7)Phosphorylation-30.1430240740
1149PhosphorylationRVVKAFRSSLYEGLE
HHHHHHHHHHHHCCC		20.4527097102
1149 (in isoform 3)Phosphorylation-20.4528551015
1150PhosphorylationVVKAFRSSLYEGLEK
HHHHHHHHHHHCCCC		30.6227097102
1150 (in isoform 7)Phosphorylation-30.6228551015
1151 (in isoform 3)Phosphorylation-4.8128551015
1151 (in isoform 7)Phosphorylation-4.8128551015
1152PhosphorylationKAFRSSLYEGLEKPE
HHHHHHHHHCCCCCC		15.2025403869
1152 (in isoform 1)Phosphorylation-15.2022673903
1152 (in isoform 2)Phosphorylation-15.2022673903
1152 (in isoform 9)Phosphorylation-15.2022673903
1153 (in isoform 7)Phosphorylation-63.7028551015
1155 (in isoform 3)Phosphorylation-5.2328551015
1156 (in isoform 10)Phosphorylation-76.9330240740
1156 (in isoform 3)Phosphorylation-76.9328551015
1157AcetylationSLYEGLEKPESRTSI
HHHHCCCCCCCCCCH		60.167632163
1157UbiquitinationSLYEGLEKPESRTSI
HHHHCCCCCCCCCCH		60.16-
1158 (in isoform 3)Phosphorylation-35.1128551015
1158 (in isoform 7)Phosphorylation-35.1128551015
1159 (in isoform 3)Phosphorylation-65.0128551015
1160PhosphorylationEGLEKPESRTSIHNF
HCCCCCCCCCCHHHH		49.7629779826
1160 (in isoform 7)Phosphorylation-49.7628551015
1161 (in isoform 1)Phosphorylation-30.7228551015
1161 (in isoform 2)Phosphorylation-30.72-
1161 (in isoform 7)Phosphorylation-30.7230240740
1161 (in isoform 9)Phosphorylation-30.72-
1162PhosphorylationLEKPESRTSIHNFMA
CCCCCCCCCHHHHCC		41.1127097102
1162 (in isoform 1)Phosphorylation-41.1130240740
1162 (in isoform 2)Phosphorylation-41.11-
1162 (in isoform 9)Phosphorylation-41.11-
1163PhosphorylationEKPESRTSIHNFMAH
CCCCCCCCHHHHCCC		22.2729779826
1163 (in isoform 7)Phosphorylation-22.2728551015
1164 (in isoform 1)Phosphorylation-2.8128551015
1165 (in isoform 1)Phosphorylation-22.6528551015
1166 (in isoform 4)Phosphorylation-27.0728551015
1167 (in isoform 1)Phosphorylation-2.5728551015
1168 (in isoform 4)Phosphorylation-3.9828551015
1172 (in isoform 1)Phosphorylation-37.3828551015
1172 (in isoform 4)Phosphorylation-37.3828551015
1173 (in isoform 11)Phosphorylation-12.8930240740
1173 (in isoform 4)Phosphorylation-12.8928551015
1174 (in isoform 1)Phosphorylation-29.7128551015
1175 (in isoform 1)Phosphorylation-9.2930240740
1175 (in isoform 4)Phosphorylation-9.2928551015
1176 (in isoform 4)Phosphorylation-47.5628551015
1177 (in isoform 1)Phosphorylation-50.6428551015
1178PhosphorylationPEFRIEDSQPHIPLI
CCEECCCCCCCCCCC		32.5927115346
1180 (in isoform 2)Phosphorylation-31.1828551015
1182 (in isoform 2)Phosphorylation-3.6528551015
1186 (in isoform 2)Phosphorylation-61.5128551015
1187 (in isoform 2)Phosphorylation-34.8228551015
1187 (in isoform 9)Phosphorylation-34.8230240740
1188PhosphorylationHIPLIDDTDLEEDAA
CCCCCCCCCHHHHHH		38.4422673903
1189 (in isoform 2)Phosphorylation-60.1128551015
1190 (in isoform 2)Phosphorylation-9.3628551015
1200PhosphorylationDAALKQNSSPPSSLN
HHHHHCCCCCCHHHC		41.5527097102
1201PhosphorylationAALKQNSSPPSSLNK
HHHHCCCCCCHHHCC		48.6727097102
1204PhosphorylationKQNSSPPSSLNKNNS
HCCCCCCHHHCCCCC		51.3328551015
1205PhosphorylationQNSSPPSSLNKNNSA
CCCCCCHHHCCCCCC		41.5628551015
1211PhosphorylationSSLNKNNSAIDSGIN
HHHCCCCCCCCCCCC		35.6728432305
1215PhosphorylationKNNSAIDSGINLTTD
CCCCCCCCCCCCCCC		35.1428432305
1220PhosphorylationIDSGINLTTDTSKSA
CCCCCCCCCCCCCCC		20.3828432305
1221PhosphorylationDSGINLTTDTSKSAT
CCCCCCCCCCCCCCC		40.2128432305
1230PhosphorylationTSKSATSSSPGSPIH
CCCCCCCCCCCCCCC		35.8828689409
1231PhosphorylationSKSATSSSPGSPIHS
CCCCCCCCCCCCCCC		32.8022108457
1234PhosphorylationATSSSPGSPIHSLET
CCCCCCCCCCCCCCC		24.8630411139
1241PhosphorylationSPIHSLETSL-----
CCCCCCCCCC-----		40.3928689409
1242PhosphorylationPIHSLETSL------
CCCCCCCCC------		23.7821630457
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1139TPhosphorylationKinasePKC-Uniprot
1201SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2B2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2B2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AT2B2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT2B2_RAT

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Related Literatures of Post-Translational Modification

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