AT2B1_RAT - dbPTM
AT2B1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT2B1_RAT
UniProt AC P11505
Protein Name Plasma membrane calcium-transporting ATPase 1
Gene Name Atp2b1
Organism Rattus norvegicus (Rat).
Sequence Length 1258
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell..
Protein Sequence MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGFLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSFRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQMDVVNAFQSGGSIQGALRRQPSIASQHHDVTNVSTPTHIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPLIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MGDMANNSV
------CCCCCCCCH		44.71-
8PhosphorylationMGDMANNSVAYSGVK
CCCCCCCCHHHHCHH		14.1327097102
11PhosphorylationMANNSVAYSGVKNSL
CCCCCHHHHCHHHHH		12.1023984901
12PhosphorylationANNSVAYSGVKNSLK
CCCCHHHHCHHHHHH		27.6323984901
17PhosphorylationAYSGVKNSLKEANHD
HHHCHHHHHHHHCCC		34.7927097102
30PhosphorylationHDGDFGITLAELRAL
CCCCCCCCHHHHHHH		21.9425575281
62UbiquitinationDVYGICTKLKTSPNE
HHHHHEEECCCCCCC		43.50-
64UbiquitinationYGICTKLKTSPNEGL
HHHEEECCCCCCCCC		48.81-
193UbiquitinationSRIEQEQKFTVIRGG
HHHHHHCCEEEEECC		42.10-
251AcetylationTGESDHVKKSLDKDP
CCCCHHHHHHCCCCC		32.9714496175
256UbiquitinationHVKKSLDKDPLLLSG
HHHHHCCCCCEEEEC		67.54-
312UbiquitinationKKEKKNKKQDGAIEN
HHHHHHHHHHCHHHC		64.12-
324UbiquitinationIENRNKAKAQDGAAM
HHCHHHHHHCCCCCC		48.46-
337UbiquitinationAMEMQPLKSEEGGDG
CCCCCCCCCCCCCCC		63.61-
338PhosphorylationMEMQPLKSEEGGDGD
CCCCCCCCCCCCCCC		48.8728432305
495AcetylationVQAYINEKHYKKVPE
HHHHHCHHHHCCCCC		47.9822902405
533UbiquitinationSKILPPEKEGGLPRH
CCCCCCHHCCCCCCC		68.39-
573PhosphorylationEIPEEALYKVYTFNS
HCCHHHHHHHHCHHH		12.88-
574AcetylationIPEEALYKVYTFNSV
CCHHHHHHHHCHHHH		29.6122902405
580PhosphorylationYKVYTFNSVRKSMST
HHHHCHHHHHHHHHH		21.0725403869
609AcetylationGASEIILKKCFKILS
CCHHHHHHHHHHHHH		36.7722902405
634UbiquitinationRDRDDIVKTVIEPMA
CCHHHHHHHHHHHHH		37.09-
634AcetylationRDRDDIVKTVIEPMA
CCHHHHHHHHHHHHH		37.0922902405
737AcetylationDFLCLEGKDFNRRIR
CEEEEECCHHHHHHH		50.1713577971
737UbiquitinationDFLCLEGKDFNRRIR
CEEEEECCHHHHHHH		50.17-
747UbiquitinationNRRIRNEKGEIEQER
HHHHHCCCCCCCHHH		66.45-
747AcetylationNRRIRNEKGEIEQER
HHHHHCCCCCCCHHH		66.4522902405
757UbiquitinationIEQERIDKIWPKLRV
CCHHHHHHHHHHHHH		44.28-
757AcetylationIEQERIDKIWPKLRV
CCHHHHHHHHHHHHH		44.2822902405
761AcetylationRIDKIWPKLRVLARS
HHHHHHHHHHHHHCC		33.6522902405
768PhosphorylationKLRVLARSSPTDKHT
HHHHHHCCCCCCHHH		34.7525403869
769PhosphorylationLRVLARSSPTDKHTL
HHHHHCCCCCCHHHH		26.6825403869
771PhosphorylationVLARSSPTDKHTLVK
HHHCCCCCCHHHHHH		60.6825403869
778UbiquitinationTDKHTLVKGIIDSTV
CCHHHHHHHHHCCCC		47.72-
806UbiquitinationTNDGPALKKADVGFA
CCCCHHHHHCCCCEE		48.28-
807UbiquitinationNDGPALKKADVGFAM
CCCHHHHHCCCCEEH		51.15-
1116PhosphorylationRGLNRIQTQMDVVNA
CCCCCHHHHHHHHHH		24.40-
1139PhosphorylationGALRRQPSIASQHHD
HHHHCCCCHHHCCCC		23.5830240740
1139 (in isoform 4)Phosphorylation-23.5830240740
1140PhosphorylationALRRQPSIASQHHDV
HHHCCCCHHHCCCCC		5.6422673903
1142 (in isoform 4)Phosphorylation-28.5125403869
1142PhosphorylationRRQPSIASQHHDVTN
HCCCCHHHCCCCCCC		28.5130240740
1151PhosphorylationHHDVTNVSTPTHIRV
CCCCCCCCCCCHHHH		30.6430240740
1155PhosphorylationTNVSTPTHIRVVNAF
CCCCCCCHHHHHHHH		13.68-
1164PhosphorylationRVVNAFRSSLYEGLE
HHHHHHHHHHHHCCC		20.4527097102
1165PhosphorylationVVNAFRSSLYEGLEK
HHHHHHHHHHHCCCC		30.6227097102
1167PhosphorylationNAFRSSLYEGLEKPE
HHHHHHHHHCCCCCC		15.2025403869
1172AcetylationSLYEGLEKPESRSSI
HHHHCCCCCCCCHHH		60.1622902405
1172UbiquitinationSLYEGLEKPESRSSI
HHHHCCCCCCCCHHH		60.16-
1175PhosphorylationEGLEKPESRSSIHNF
HCCCCCCCCHHHHHH		46.0929779826
1177PhosphorylationLEKPESRSSIHNFMT
CCCCCCCHHHHHHCC		42.8127097102
1178PhosphorylationEKPESRSSIHNFMTH
CCCCCCHHHHHHCCC		27.1030411139
1182PhosphorylationSRSSIHNFMTHPEFR
CCHHHHHHCCCCCCC		3.55-
1184PhosphorylationSSIHNFMTHPEFRIE
HHHHHHCCCCCCCCC		30.0927097102
1193PhosphorylationPEFRIEDSEPLIPLI
CCCCCCCCCCCEECC		28.46-
1203PhosphorylationLIPLIDDTDAEDDAP
CEECCCCCCCCCCCC		33.10-
1215PhosphorylationDAPTKRNSSPPPSPN
CCCCCCCCCCCCCCC		48.5329779826
1216PhosphorylationAPTKRNSSPPPSPNK
CCCCCCCCCCCCCCC		45.0023712012
1220PhosphorylationRNSSPPPSPNKNNNA
CCCCCCCCCCCCCCC		47.0529779826
1230PhosphorylationKNNNAVDSGIHLTIE
CCCCCCCCCEEEEEE		32.8026437020
1241PhosphorylationLTIEMNKSATSSSPG
EEEEECCCCCCCCCC		31.6027097102
1243PhosphorylationIEMNKSATSSSPGSP
EEECCCCCCCCCCCC		35.9127097102
1244PhosphorylationEMNKSATSSSPGSPL
EECCCCCCCCCCCCC		28.6527097102
1245PhosphorylationMNKSATSSSPGSPLH
ECCCCCCCCCCCCCH		35.8827097102
1246PhosphorylationNKSATSSSPGSPLHS
CCCCCCCCCCCCCHH		32.8027097102
1249PhosphorylationATSSSPGSPLHSLET
CCCCCCCCCCHHHCC		27.8923712012
1253PhosphorylationSPGSPLHSLETSL--
CCCCCCHHHCCCC--		35.2727097102
1256PhosphorylationSPLHSLETSL-----
CCCHHHCCCC-----		40.3927097102
1257PhosphorylationPLHSLETSL------
CCHHHCCCC------		23.7827097102
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1116TPhosphorylationKinasePKC-Uniprot
1177SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT2B1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT2B1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AT2B1_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT2B1_RAT

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Related Literatures of Post-Translational Modification

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