AT1B1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT1B1_RAT
• UniProt AC: P07340
• Protein Name: Sodium/potassium-transporting ATPase subunit beta-1
• Gene Name: Atp1b1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 304
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein . Cell membrane, sarcolemma . Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
• Protein Description: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.; Involved in cell adhesion and establishing epithelial cell polarity..
• Protein Sequence: MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIIRFLEKYKDSAQKDDMIFEDCGSMPSEPKERGEFNHERGERKVCRFKLDWLGNCSGLNDESYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPLTMKYNPNVLPVQCTGKRDEDKDKVGNIEYFGMGGFYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTLDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MARGKAKEEGSWKK -CCCCCCCCCCCCCC	60.84	22902405
7	Ubiquitination	-MARGKAKEEGSWKK -CCCCCCCCCCCCCC	60.84	-
11	Phosphorylation	GKAKEEGSWKKFIWN CCCCCCCCCCCEEEE	38.71	22673903
13	Ubiquitination	AKEEGSWKKFIWNSE CCCCCCCCCEEEECH	39.23	-
14	Acetylation	KEEGSWKKFIWNSEK CCCCCCCCEEEECHH	35.50	22902405
14	Ubiquitination	KEEGSWKKFIWNSEK CCCCCCCCEEEECHH	35.50	-
19	Phosphorylation	WKKFIWNSEKKEFLG CCCEEEECHHHHHHC	35.48	22673903
21	Acetylation	KFIWNSEKKEFLGRT CEEEECHHHHHHCCC	58.38	22902405
21	Ubiquitination	KFIWNSEKKEFLGRT CEEEECHHHHHHCCC	58.38	-
22	Acetylation	FIWNSEKKEFLGRTG EEEECHHHHHHCCCC	50.04	22902405
85	Acetylation	TQIPQIQKTEISFRP CCCCCCEEEEEEECC	50.16	22902405
101	Phosphorylation	DPKSYEAYVLNIIRF CCHHHHHHHHHHHHH	8.11	-
111	Acetylation	NIIRFLEKYKDSAQK HHHHHHHHHHHHHCC	60.80	22902405
158	N-linked_Glycosylation	FKLDWLGNCSGLNDE EECCCCCCCCCCCCC	18.01	24090084
179	Acetylation	GKPCIIIKLNRVLGF CCEEEEEEECCCCCC	29.33	22902405
193	N-linked_Glycosylation	FKPKPPKNESLETYP CCCCCCCCCCCCCEE	50.27	24090084
217	Acetylation	LPVQCTGKRDEDKDK ECEECCCCCCCCCCC	38.22	14496143
266	N-linked_Glycosylation	LLAVQFTNLTLDTEI EEEEEEECCEECCEE	32.11	-
287	Phosphorylation	YGENIGYSEKDRFQG CCCCCCCCHHHCCCC	32.72	22673903
289	Acetylation	ENIGYSEKDRFQGRF CCCCCCHHHCCCCEE	48.54	22902405
299	Acetylation	FQGRFDVKIEVKS-- CCCEEEEEEEECC--	34.69	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT1B1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT1B1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT1B1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AT1B1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.