AT10A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT10A_HUMAN
• UniProt AC: O60312
• Protein Name: Probable phospholipid-transporting ATPase VA
• Gene Name: ATP10A
• Organism: Homo sapiens (Human).
• Sequence Length: 1499
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane . Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
• Protein Description: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable)..
• Protein Sequence: MEREPAGTEEPGPPGRRRRREGRTRTVRSNLLPPPGAEDPAAGAAKGERRRRRGCAQHLADNRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSDHKINHLGCLVFSREEKKYVNRFWKEIHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGCIIHDNGKKAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVLWCVLLLVCMSLFSAVGHGLWIWRYQEKKSLFYVPKSDGSSLSPVTAAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQRLARYQEADSEEEEVVPRGGSVSQRGSIGSHQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDKSLAVARHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRTKVRVRFELKSPVKTIEDFLRRFTPSCLTSGCSSIGSLAANKSSHKLGSSFPSTPSSDGMLLRLEERLGQPTSAIASNGYSSQADNWASELAQEQESERELRYEAESPDEAALVYAARAYNCVLVERLHDQVSVELPHLGRLTFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDLLQPCSSVDARGRHQKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLENSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYACKLLDHDEEVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFSSLCPPSTSTASGRRPSLVIDGRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQNMEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNVDLFTWGTPIVTIALLTFLLHLGIETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPPSNPYWTMQALLGDPVFYLTCLMTPVAALLPRLFFRSLQGRVFPTQLQLARQLTRKSPRRCSAPKETFAQGRLPKDSGTEHSSGRTVKTSVPLSQPSWHTQQPVCSLEASGEPSTVDMSMPVREHTLLEGLSAPAPMSSAPGEAVLRSPGGCPEESKVRAASTGRVTPLSSLFSLPTFSLLNWISSWSLVSRLGSVLQFSRTEQLADGQAGRGLPVQPHSGRSGLQGPDHRLLIGASSRRSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEREPAGTEEPGPPG CCCCCCCCCCCCCCC	39.00	24719451
123	Ubiquitination	LFILAITAFRDLWED HHHHHHHHHHHHHHH	7.43	22817900
258	Phosphorylation	NGKKAGLYKENLLLR CCCEECCCCCCEECC	18.48	22817900
281	Ubiquitination	AVVGIVIYAGHETKA CEEEEEEEECHHHHH	8.81	22817900
281	Phosphorylation	AVVGIVIYAGHETKA CEEEEEEEECHHHHH	8.81	23403867
286	Phosphorylation	VIYAGHETKALLNNS EEEECHHHHHHHHCC	18.88	23403867
293	Phosphorylation	TKALLNNSGPRYKRS HHHHHHCCCHHHHHH	49.45	-
297	Phosphorylation	LNNSGPRYKRSKLER HHCCCHHHHHHHHHH	17.56	-
415	Phosphorylation	QCRALNITEDLGQIQ HHHHHCCCCCHHCCE	23.52	30206219
423	Phosphorylation	EDLGQIQYIFSDKTG CCHHCCEEEECCCCC	12.93	30206219
426	Phosphorylation	GQIQYIFSDKTGTLT HCCEEEECCCCCCCC	28.74	30206219
428	Ubiquitination	IQYIFSDKTGTLTEN CEEEECCCCCCCCCC	47.89	22817900
429	Phosphorylation	QYIFSDKTGTLTENK EEEECCCCCCCCCCE	40.15	30206219
431	Phosphorylation	IFSDKTGTLTENKMV EECCCCCCCCCCEEE	35.42	30206219
433	Phosphorylation	SDKTGTLTENKMVFR CCCCCCCCCCEEEEE	37.03	30206219
461	Phosphorylation	NAQRLARYQEADSEE HHHHHHHHHCCCCCC	12.71	29978859
466	Phosphorylation	ARYQEADSEEEEVVP HHHHCCCCCCCCCCC	54.69	28450419
483	Phosphorylation	GSVSQRGSIGSHQSV CCCCCCCCCCCCCCE	26.43	24961811
501	Phosphorylation	HRTQSTKSHRRTGSR EECCCCCCCCCCCCH	23.47	23403867
505	Phosphorylation	STKSHRRTGSRAEAK CCCCCCCCCCHHHHH	39.19	23403867
515	Phosphorylation	RAEAKRASMLSKHTA HHHHHHHHHHHHHCC	25.04	29396449
518	Phosphorylation	AKRASMLSKHTAFSS HHHHHHHHHHCCCCC	17.47	24719451
521	Phosphorylation	ASMLSKHTAFSSPME HHHHHHHCCCCCCCC	32.89	24719451
524	Phosphorylation	LSKHTAFSSPMEKDI HHHHCCCCCCCCCCC	30.94	28509920
723	Phosphorylation	ERLHDQVSVELPHLG ECCCCCCCCCCCHHH	12.30	-
750	Phosphorylation	DSVRKRMSVVIRHPL HHHHHHEEEEECCCC	19.77	-
780	Phosphorylation	MDLLQPCSSVDARGR HHHHHCCCCCCCCCH	39.83	29978859
781	Phosphorylation	DLLQPCSSVDARGRH HHHHCCCCCCCCCHH	30.63	29978859
799	Phosphorylation	IRSKTQNYLNVYAAE HHHHCCHHHHHHHHH	6.99	-
803	Phosphorylation	TQNYLNVYAAEGLRT CCHHHHHHHHHHHHH	10.06	-
962	Phosphorylation	SSLCPPSTSTASGRR HHCCCCCCCCCCCCC	35.55	26657352
964	Phosphorylation	LCPPSTSTASGRRPS CCCCCCCCCCCCCCE	25.57	26657352
966	Phosphorylation	PPSTSTASGRRPSLV CCCCCCCCCCCCEEE	32.68	-
985	Acetylation	SLAYALEKNLEDKFL HHHHHHHHCCHHHHH	68.62	24431031
990	Acetylation	LEKNLEDKFLFLAKQ HHHCCHHHHHHHHHH	34.29	24431041
1026	Phosphorylation	RSKLKAMTLAIGDGA HHHHHHHHHHHCCCC	20.21	28111955
1037	Phosphorylation	GDGANDVSMIQVADV CCCCCCCEEEEEEEE	17.03	28111955
1049	Phosphorylation	ADVGVGISGQEGMQA EEEECCCCCHHHHHH	28.61	28111955
1060	Phosphorylation	GMQAVMASDFAVPKF HHHHHHHCCCCCCHH	18.37	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT10A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT10A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT10A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AT10A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 105830: Angelman syndrome (AS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.