ASXL3_HUMAN - dbPTM
ASXL3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASXL3_HUMAN
UniProt AC Q9C0F0
Protein Name Putative Polycomb group protein ASXL3
Gene Name ASXL3
Organism Homo sapiens (Human).
Sequence Length 2248
Subcellular Localization Nucleus .
Protein Description Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity)..
Protein Sequence MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETSGTSPLACLNAMLHTNTRIGDGTFFKIPGKSGLYALKKEESSCPADGTLDLVCESELDGTDMAEANAHGEENGVCSKQVTDEASSTRDSSLTNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGEKLGMSREESVKLTTGPNNAGAQSSSSCGTSGLPVSAQTALAEQQPKSMKSPASPEPGFCATLCPMVEIPPKDIMAELESEDILIPEESVIQEEIAEEVETSICECQDENHKTIPEFSEEAESLTNSHEEPQIAPPEDNLESCVMMNDVLETLPHIEVKIEGKSESPQEEMTVVIDQLEVCDSLIPSTSSMTHVSDTEHKESETAVETSTPKIKTGSSSLEGQFPNEGIAIDMELQSDPEEQLSENACISETSFSSESPEGACTSLPSPGGETQSTSEESCTPASLETTFCSEVSSTENTDKYNQRNSTDENFHASLMSEISPISTSPEISEASLMSNLPLTSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTSETTFVSSLPLPSETSPISNSSINERMAHQQRKSPSVSEEPLSPQKDESSATAKPLGENLTSQQKNLSNTPEPIIMSSSSIAPEAFPSEDLHNKTLSQQTCKSHVDTEKPYPASIPELASTEMIKVKNHSVLQRTEKKVLPSPLELSVFSEGTDNKGNELPSAKLQDKQYISSVDKAPFSEGSRNKTHKQGSTQSRLETSHTSKSSEPSKSPDGIRNESRDSEISKRKTAEQHSFGICKEKRARIEDDQSTRNISSSSPPEKEQPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPESRASTSTSVSGGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKTRTLAHIKEQTKAKLFAKHQARAHLFQTSKETRLPPPLSSKEGPPNLEVSSTPETKMEGSTGVIIVNPNCRSPSNKSAHLRETTTVLQQSLNPSKLPETATDLSVHSSDENIPVSHLSEKIVSSTSSENSSVPMLFNKNSVPVSVCSTAISGAIKEHPFVSSVDKSSVLMSVDSANTTISACNISMLKTIQGTDTPCIAIIPKCIESTPISATTEGSSISSSMDDKQLLISSSSASNLVSTQYTSVPTPSIGNNLPNLSTSSVLIPPMGINNRFPSEKIAIPGSEEQATVSMGTTVRAALSCSDSVAVTDSLVAHPTVAMFTGNMLTINSYDSPPKLSAESLDKNSGPRNRADNSGKPQQPPGGFAPAAINRSIPCKVIVDHSTTLTSSLSLTVSVESSEASLDLQGRPVRTEASVQPVACPQVSVISRPEPVANEGIDHSSTFIAASAAKQDSKTLPATCTSLRELPLVPDKLNEPTAPSHNFAEQARGPAPFKSEADTTCSNQYNPSNRICWNDDGMRSTGQPLVTHSGSSKQKEYLEQSCPKAIKTEHANYLNVSELHPRNLVTNVALPVKSELHEADKGFRMDTEDFPGPELPPPAAEGASSVQQTQNMKASTSSPMEEAISLATDALKRVPGAGSSGCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLQTTSVGKTAPERNVEIPPSSPNPDGKGYLAGTLAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLVEPDVKGVPCVISSGISQLGHSQPFKQEWLNKHSMQNRIVHSPEVKQQKRLLPSCSFQQNLFHVDKNGGFHTDAGTSHRQQFYQMPVAARGPIPTAALLQASSKTPVGCNAFAFNRHLEQKGLGEVSLSSAPHQLRLANMLSPNMPMKEGDEVGGTAHTMPNKALVHPPPPPPPPPPPPLALPPPPPPPPPLPPPLPNAEVPSDQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQVSYDQNEMKEQLKAFALKSADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNYPTIHFGSTSFKRAASAIEKSIGILGSGSNPATGLSGQNAQMPVQNFADSSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
139PhosphorylationRDSSLTNTAVQSKLV
CCCCHHHHHHHHHHH		23.9930257219
185PhosphorylationTVPRVVLTPLKVSDE
CCCEEEEEEEECCCC		18.2421815630
209PhosphorylationSKNGEADSSDKEMKH
CCCCCCCCCHHHHCC		47.7022115753
210PhosphorylationKNGEADSSDKEMKHG
CCCCCCCCHHHHCCC		53.9323663014
220PhosphorylationEMKHGQKSPTGKQTS
HHCCCCCCCCHHHHH		21.5824719451
342UbiquitinationRIRQEIEKEKKTEPW
HHHHHHHHHCCCCHH		79.20-
350UbiquitinationEKKTEPWKEKFFERF
HCCCCHHHHHHHHHH		62.8432015554
352UbiquitinationKTEPWKEKFFERFYG
CCCHHHHHHHHHHHH		52.18-
358PhosphorylationEKFFERFYGEKLGMS
HHHHHHHHHHHCCCC		30.5126657352
365PhosphorylationYGEKLGMSREESVKL
HHHHCCCCHHHCEEC		34.4426657352
369PhosphorylationLGMSREESVKLTTGP
CCCCHHHCEECCCCC		21.5726657352
771PhosphorylationMAHQQRKSPSVSEEP
HHHHCCCCCCCCCCC		25.2920363803
773PhosphorylationHQQRKSPSVSEEPLS
HHCCCCCCCCCCCCC		45.4220363803
780PhosphorylationSVSEEPLSPQKDESS
CCCCCCCCCCCCCCC		35.6820363803
840PhosphorylationLSQQTCKSHVDTEKP
CCHHHHHHCCCCCCC		30.7821130716
857PhosphorylationASIPELASTEMIKVK
CCCHHHCCCEEEEEC		37.2121130716
858PhosphorylationSIPELASTEMIKVKN
CCHHHCCCEEEEECC		24.7821130716
899PhosphorylationNKGNELPSAKLQDKQ
CCCCCCCCCHHCCHH		51.1424719451
929PhosphorylationNKTHKQGSTQSRLET
CCCCCCCCCHHHHHC		22.30-
936PhosphorylationSTQSRLETSHTSKSS
CCHHHHHCCCCCCCC		30.33-
937PhosphorylationTQSRLETSHTSKSSE
CHHHHHCCCCCCCCC		18.52-
942PhosphorylationETSHTSKSSEPSKSP
HCCCCCCCCCCCCCC		39.44-
943PhosphorylationTSHTSKSSEPSKSPD
CCCCCCCCCCCCCCC		58.21-
948PhosphorylationKSSEPSKSPDGIRNE
CCCCCCCCCCCCCCC		32.3424719451
987PhosphorylationARIEDDQSTRNISSS
CCCCCCCCCCCCCCC		36.0122468782
995PhosphorylationTRNISSSSPPEKEQP
CCCCCCCCCCCCCCC		46.5522468782
1017PhosphorylationPPLKIQLSKIGPPFI
CCCEEEHHHCCCCEE		13.07-
1027PhosphorylationGPPFIIKSQPVSKPE
CCCEEEECCCCCCCC		29.34-
1031PhosphorylationIIKSQPVSKPESRAS
EEECCCCCCCCCCCC		49.5326471730
1035PhosphorylationQPVSKPESRASTSTS
CCCCCCCCCCCCCCC		41.4924667141
1084PhosphorylationAAAASIVSGAMGSPG
HHHHHHHHCCCCCCC		21.1128348404
1089PhosphorylationIVSGAMGSPGEGGKT
HHHCCCCCCCCCCCC		19.35-
1167PhosphorylationIVNPNCRSPSNKSAH
EECCCCCCCCCCCCH		34.5832142685
1239PhosphorylationNKNSVPVSVCSTAIS
CCCCCCHHHHHHHHH		16.0127050516
1243PhosphorylationVPVSVCSTAISGAIK
CCHHHHHHHHHHHHH		23.9227050516
1246PhosphorylationSVCSTAISGAIKEHP
HHHHHHHHHHHHHCC		21.5127050516
1396PhosphorylationTTVRAALSCSDSVAV
HHHHHHHHCCCCEEH		13.5725332170
1484PhosphorylationHSTTLTSSLSLTVSV
CCCEEEEEEEEEEEE		19.42-
1644PhosphorylationSCPKAIKTEHANYLN
HCCHHHHHHCCCCCC		27.2227307780
1649PhosphorylationIKTEHANYLNVSELH
HHHHCCCCCCHHHCC		10.6327307780
1653PhosphorylationHANYLNVSELHPRNL
CCCCCCHHHCCCCCC		33.1127307780
1883PhosphorylationQEWLNKHSMQNRIVH
HHHHHHHHCCCCCCC		24.5528188228
1891PhosphorylationMQNRIVHSPEVKQQK
CCCCCCCCHHHHHHH		16.3226074081
2005PhosphorylationEGDEVGGTAHTMPNK
CCCCCCCCCCCCCCC		14.8828634298
2008PhosphorylationEVGGTAHTMPNKALV
CCCCCCCCCCCCCCC		31.6828634298
2060PhosphorylationDQKQPPVTMETTKRL
CCCCCCCCHHHCCCC		18.3123403867
2063PhosphorylationQPPVTMETTKRLSWP
CCCCCHHHCCCCCCC		27.1323403867
2064PhosphorylationPPVTMETTKRLSWPQ
CCCCHHHCCCCCCCC		10.8123403867
2119PhosphorylationLKAFALKSADFSSYL
HHHHHHHHCCHHHHH		33.6427732954
2123PhosphorylationALKSADFSSYLLSEP
HHHHCCHHHHHCCCC		20.7227732954
2124PhosphorylationLKSADFSSYLLSEPQ
HHHCCHHHHHCCCCC		21.5727732954
2125PhosphorylationKSADFSSYLLSEPQK
HHCCHHHHHCCCCCC		15.5127732954
2128PhosphorylationDFSSYLLSEPQKPFT
CHHHHHCCCCCCHHH		44.6427732954
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASXL3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASXL3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASXL3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BAP1_HUMANBAP1physical
26647312
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASXL3_HUMAN

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Related Literatures of Post-Translational Modification

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