ASXL1_MOUSE - dbPTM
ASXL1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASXL1_MOUSE
UniProt AC P59598
Protein Name Putative Polycomb group protein ASXL1
Gene Name Asxl1
Organism Mus musculus (Mouse).
Sequence Length 1514
Subcellular Localization Nucleus .
Protein Description Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1)..
Protein Sequence MKDKQKRKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKKDAVQWSRNAATVDGDEPEDSADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSHRASSQANKQKKRTGVMLPRVVLTPLKVNGAHVEPASGFSGRHADGESGSPSSSSSGSLALGNSAIRGQAEVTRDPAPLLRGFRKPATGQMKRNRGEEVDFETPGSILVNTNLRALINSRTFHALPLHFQQQLLLLLPEVDRQVGTDGLLRLSGSALNNEFFTHAAQSWRERLADGEFTHEMQVRLRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQKEVQEEAKVKSGLCVSGESVRPQRGPNTRQRDGHFKKRSRPDLRTRSRRNIYKKQEPEQAGVAKDASAAPDVSLSKDTKTDLAGVNSTPGPDVSSATSGQEGPKCPSEPVASQIQAERDNLACASASPDRIPTLPQDTVDQETKDQKRKSFEQEASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVAKGRPTYQICPRIVPITESSCRGWTGARTLADIKARALQARGARGYHCNRETATTAIGGGGGPGGGGSGAIDEGGGRDSSSGDGSEACGHPEPRGAPSTSGESASDLQRTQLLPPCPLNGEHTPAEAAMPRARREDSASLRKEESCLLKRVPGVLTSGLEDASQPPIAPTGDQPCQALPPLSSQTPVAEMLTEQPKLLLDDRTECESSREDQGPTIPSESSSGRFPLGDLLGGGSDQAFDNMKEPVSMTPTFISELSLANYLQDRPDDDGLGLGATGLLIRESSRQEALTEAFASGSPTSWVPILSNYEVIKTSDPESRENIPCPEPQDEKEWERAVPLIAATESVPQPESCISHWTPPPAAVGSTGSDSEQVDLERLEMNGISEAPSPHSESTDTASDSEGHLSEDSSEVDASEVTVVKGSLGGDEKQDWDPSASLSKVNNDLSVLTRTGGVAASQSWVSRVCSVPHKIPDSLLLSSTECQPRSVCPLRPGSSVEVTNPLVMHLLHGNLPLEKVLPPGHRSSRLESSQLPLREQSQDRGTLQGTGENNRLAARINPGSAQTLKESILAQSYGASAGLVRAMASKAPAMSQKIAKMVTSLDSQHPETELTPSSGNLEEIDSKEHLSSFLCEEQKEGHSLSQGSDPGAAPGQCLGDHTTSKVPCFSSTNVSLSFGSEQTDGTLSDQNNAGGHEKKLFGPGNTVTTLQCPRSEEQTPLPAEVPPVFPSRKIEPSKNSVSGGVQTTRENRMPKPPPVSADSIKTEQTFLRDPIKADAENRKAAGYSSLELVGHLQGMPFVVDLPFWKLPREPGKGFSQPLEPSSIPSQLNIKQALYGKLSKLQLSPTSFNYSSSSATFPKGLAGGVVQLSHKASFGTGHTASLSLQMFADSSAVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
199PhosphorylationGRHADGESGSPSSSS
CCCCCCCCCCCCCCC		50.5323984901
201PhosphorylationHADGESGSPSSSSSG
CCCCCCCCCCCCCCC		30.7825266776
203PhosphorylationDGESGSPSSSSSGSL
CCCCCCCCCCCCCCC		44.5423984901
204PhosphorylationGESGSPSSSSSGSLA
CCCCCCCCCCCCCCC		37.3123984901
205PhosphorylationESGSPSSSSSGSLAL
CCCCCCCCCCCCCCC		32.6223984901
206PhosphorylationSGSPSSSSSGSLALG
CCCCCCCCCCCCCCC		40.4423984901
207PhosphorylationGSPSSSSSGSLALGN
CCCCCCCCCCCCCCC		34.0623984901
209PhosphorylationPSSSSSGSLALGNSA
CCCCCCCCCCCCCCH		16.6523984901
351UbiquitinationEKKVEQWKEKFFEDY
HHHHHHHHHHHHHHH		51.20-
353UbiquitinationKVEQWKEKFFEDYYG
HHHHHHHHHHHHHHH		52.18-
440PhosphorylationAGVAKDASAAPDVSL
CCCCCCCCCCCCCCC		34.7922871156
446PhosphorylationASAAPDVSLSKDTKT
CCCCCCCCCCCCCCC		34.0122871156
498PhosphorylationRDNLACASASPDRIP
HHCCCHHCCCCCCCC		29.2125619855
500PhosphorylationNLACASASPDRIPTL
CCCHHCCCCCCCCCC		25.4925521595
506PhosphorylationASPDRIPTLPQDTVD
CCCCCCCCCCCCCCC		49.0125619855
523PhosphorylationTKDQKRKSFEQEASA
HHHHHHHHHHHHHHH		37.7425338131
574PhosphorylationPPIRIQLSRIKPPWV
CCEEEEEECCCCCCH		18.65-
1140O-linked_GlycosylationAARINPGSAQTLKES
EEECCCCCHHHHHHH		20.6130059200
1285PhosphorylationGPGNTVTTLQCPRSE
CCCCEEEEEECCCCC		15.5322817900
1342PhosphorylationVSADSIKTEQTFLRD
CCHHHCCCCHHHHHC		31.49-
1345PhosphorylationDSIKTEQTFLRDPIK
HHCCCCHHHHHCCHH		20.57-
1423PhosphorylationKLSKLQLSPTSFNYS
HHHCCCCCCCCCCCC		17.1126643407
1425PhosphorylationSKLQLSPTSFNYSSS
HCCCCCCCCCCCCCC		42.4426643407
1426PhosphorylationKLQLSPTSFNYSSSS
CCCCCCCCCCCCCCC		18.1926745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASXL1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASXL1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASXL1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ASXL1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASXL1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500, AND MASSSPECTROMETRY.

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