| UniProt ID | ASIC2_HUMAN | |
|---|---|---|
| UniProt AC | Q16515 | |
| Protein Name | Acid-sensing ion channel 2 {ECO:0000303|PubMed:10842183} | |
| Gene Name | ASIC2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 512 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.. |
|
| Protein Description | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.. | |
| Protein Sequence | MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MDLKESPSEGSLQPS CCCCCCCCCCCCCCC | 64.96 | 25332170 | |
| 11 | Phosphorylation | KESPSEGSLQPSSIQ CCCCCCCCCCCCEEE | 21.56 | - | |
| 39 | Phosphorylation | IFVYGPLTIRRVLWA EEEECCHHHHHHHHH | 18.64 | 12399460 | |
| 134 (in isoform 2) | Phosphorylation | - | 3.60 | - | |
| 357 | Phosphorylation | LAEKDSNYCLCRTPC HHHCCCCEEEECCCC | 7.25 | - | |
| 365 | N-linked_Glycosylation | CLCRTPCNLTRYNKE EEECCCCCCCCCCCC | 45.72 | UniProtKB CARBOHYD | |
| 380 | Phosphorylation | LSMVKIPSKTSAKYL CCEEECCCHHHHHHH | 52.63 | 24719451 | |
| 392 | N-linked_Glycosylation | KYLEKKFNKSEKYIS HHHHHHCCCCHHCCC | 56.68 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ASIC2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ASIC2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ASIC2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ASIC3_HUMAN | ASIC3 | physical | 10842183 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
