ASCC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASCC2_MOUSE
• UniProt AC: Q91WR3
• Protein Name: Activating signal cointegrator 1 complex subunit 2
• Gene Name: Ascc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 749
• Subcellular Localization: Nucleus .
• Protein Description: Enhances NF-kappa-B, SRF and AP1 transactivation..
• Protein Sequence: MPALPLDQLQITHKDPKTGQPKTSAALNPEQKADRYFVLYKPPPKDNIPALVEEYLERANFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLHYVPRKFDEWVAPTPEVADMQNHLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYTDLDETIPTILQVFSNILQHCGLQGDGTSTTPQKLGERSPLTPSDMPLLELKDIVLYLCDTSTTLWAFLDIFPLACQTFQKHDFCYRLASFYEMAIPELESAIKKRRLEDSKLLGDMWQRLSHSKKKLMEVFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDTFSPVAEDISLLQQASSALDETRTAYILQAVESAWEGVDRQKIKDIKDPPRAKGSNNEVTVTAEPVSEMPSQLENLEEDEECMGAAAALGPAVSGVELDSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILEDRLAPELSQLDRGLERQVKPDPTPLLSSRHNIFQNDEFDVFSRDSVDLSRVHKGRRKEENVRSLVNDKQAVVAQWQRYQKYSVVVEEVPLQPGEYQADDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKMPGEVQEEEWDEEDEVEEEAPKPDHFIQDPAVLREKAEARRMAFLARKGYRPENSTAVTGGPRGHGQSRETTQERRKKEANKAARANHNRRTMADRKRSKGMIPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	IPALVEEYLERANFV CHHHHHHHHHHCCCH	10.60	28059163
230	Phosphorylation	PQKLGERSPLTPSDM CHHCCCCCCCCCCCC	21.69	26824392
233	Phosphorylation	LGERSPLTPSDMPLL CCCCCCCCCCCCCHH	24.91	26824392
528	Phosphorylation	RQVKPDPTPLLSSRH HHCCCCCCCCCCCCC	33.67	20469934
532	Phosphorylation	PDPTPLLSSRHNIFQ CCCCCCCCCCCCCCC	32.77	29514104
533	Phosphorylation	DPTPLLSSRHNIFQN CCCCCCCCCCCCCCC	37.21	29514104
587	Phosphorylation	WQRYQKYSVVVEEVP HHHHHEEEEEEEECC	18.57	23649490
612	Phosphorylation	YEDEYDDTYDGNQVG CCCCCCCCCCCCCCC	22.18	23649490
625	Phosphorylation	VGANDADSDDELISR CCCCCCCCCHHHHHC	49.00	23649490
722	Acetylation	TTQERRKKEANKAAR HHHHHHHHHHHHHHH	61.31	6568471
726	Acetylation	RRKKEANKAARANHN HHHHHHHHHHHHHHH	50.93	6568381
743	Phosphorylation	TMADRKRSKGMIPS- HHHHHHHHCCCCCC-	36.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASCC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASCC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASCC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ASCC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.