AS3MT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AS3MT_HUMAN
• UniProt AC: Q9HBK9
• Protein Name: Arsenite methyltransferase
• Gene Name: AS3MT
• Organism: Homo sapiens (Human).
• Sequence Length: 375
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)..
• Protein Sequence: MAALRDAEIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIPEHLENCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLGEAGIKNESHDIVVSNCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGALYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYNGGITGHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKLAEESDSMKSRCVPDAAGGCCGTKKSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	LRDAEIQKDVQTYYG CCHHHHHHHHHHHHH	66.58	29967540
16	Phosphorylation	IQKDVQTYYGQVLKR HHHHHHHHHHHHHHH	6.63	29978859
17	Phosphorylation	QKDVQTYYGQVLKRS HHHHHHHHHHHHHHC	12.41	25884760
22	Ubiquitination	TYYGQVLKRSADLQT HHHHHHHHHCCCCCC	45.51	32015554
95	Ubiquitination	LSQLVGEKGHVTGID HHHHHCCCCEEEEEE	48.68	32015554
99	Phosphorylation	VGEKGHVTGIDMTKG HCCCCEEEEEECCCC	23.81	-
104	Phosphorylation	HVTGIDMTKGQVEVA EEEEEECCCCCHHHH	28.42	-
105	Ubiquitination	VTGIDMTKGQVEVAE EEEEECCCCCHHHHH	40.48	32015554
154	Phosphorylation	ESHDIVVSNCVINLV CCCCEEEECCEEEEC	17.39	29052541
311	Ubiquitination	EETAAILKNSRFAQD HHHHHHHHCCHHCCC	46.92	32015554
335	Phosphorylation	LPTSGGCSALELKDI CCCCCCCCEEEHHHH	38.88	18334919
340	Ubiquitination	GCSALELKDIITDPF CCCEEEHHHHHCCHH	37.19	21963094
353	Phosphorylation	PFKLAEESDSMKSRC HHHHHHCCHHHHHCC	26.87	21601212
355	Phosphorylation	KLAEESDSMKSRCVP HHHHCCHHHHHCCCC	37.07	26471730
371	O-linked_Glycosylation	AAGGCCGTKKSC--- CCCCCCCCCCCC---	22.76	30379171

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AS3MT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AS3MT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AS3MT_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AS3MT_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.