ARSB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARSB_RAT
• UniProt AC: P50430
• Protein Name: Arylsulfatase B
• Gene Name: Arsb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 528
• Subcellular Localization: Lysosome. Cell surface .
• Protein Description: Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. [PubMed: 24311516 In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels]
• Protein Sequence: MGELSGCTGGSRAGGPGPRLPLLLLLLLWPARASDAAPPPHVVFVLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHMGLQHYLIMTCQPNCVPLDEKLLPQLLKDAGYATHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIECLNGTRCALDLRDGEEPAKEYTDIYSTNIFTKRATTLIANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYDFIQDKHRRIYAGMVSLLDEAVGNVTKALKSRGLWNNTVLIFSTDNGGQTRSGGNNWPLRGRKGTLWEGGIRGAGFVASPLLKQKGVKSRELMHITDWLPTLVNLAGGSTHGTKPLDGFDVWETISEGSPSPRVELLLNIDPDFFDGLPCPGKNTTPEKNDSFPLEHSAFNTSIHAGIRYKNWKLLTGYPGCGYWFPPPSQSNISEVPSVDSPTKTLWLFDINRDPEERHDVSREHPHIVQNLLSRLQYYHEHSVPSYFPPLDPRCDPKGTGVWSPWM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	3-oxoalanine (Cys)	NYYVQPLCTPSRSQL CEEECCCCCCCHHHH	7.18	-
86	Oxidation	NYYVQPLCTPSRSQL CEEECCCCCCCHHHH	7.18	-
183	N-linked_Glycosylation	CAPIECLNGTRCALD ECCEEHHCCCEEEEE	62.54	-
274	N-linked_Glycosylation	LLDEAVGNVTKALKS HHHHHHHHHHHHHHH	31.52	-
286	N-linked_Glycosylation	LKSRGLWNNTVLIFS HHHCCCCCCEEEEEE	39.06	-
379	Phosphorylation	WETISEGSPSPRVEL HHCCCCCCCCCCEEE	20.39	22668510
381	Phosphorylation	TISEGSPSPRVELLL CCCCCCCCCCEEEEE	27.34	22668510
410	N-linked_Glycosylation	KNTTPEKNDSFPLEH CCCCCCCCCCCCCCC	48.79	-
421	N-linked_Glycosylation	PLEHSAFNTSIHAGI CCCCHHCCCEECCCC	32.41	-
453	N-linked_Glycosylation	FPPPSQSNISEVPSV CCCCCCCCCCCCCCC	33.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARSB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARSB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARSB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ARSB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.