ARP8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARP8_MOUSE
• UniProt AC: Q8R2S9
• Protein Name: Actin-related protein 8
• Gene Name: Actr8
• Organism: Mus musculus (Mouse).
• Sequence Length: 624
• Subcellular Localization: Nucleus. Chromosome. Specifically localizes to mitotic chromosomes..
• Protein Description: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity)..
• Protein Sequence: MTQAEKGDAENGKEKGGEKEKEQRGVKRPIVPALVPESLQEQIQSNFIVVIHPGSTTLRLGRATDTLPVSVPHVIARRHKQQGQPLYKDNWLLREGLNKPESNEQRQNGLKMVDQAIWSKKMSNGTRRIPVSPEQTRSYNKQMRPAILDHCSGNKWTNTSQQPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVHMILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLASSQGDCLMAGNESEEALTALMSRKTAISLFEGKALGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTQAEKGD -------CCCCCCCC	5.90	-
132	Phosphorylation	GTRRIPVSPEQTRSY CCEECCCCHHHHHHC	19.84	27087446
136	Phosphorylation	IPVSPEQTRSYNKQM CCCCHHHHHHCCHHC	21.66	28833060
225	Ubiquitination	KYLEIPLKDLKYYRC HHHCCCHHHCCCEEE	56.51	22790023
412	Phosphorylation	MTTLQHRSQGDPEDP HCCCCCCCCCCCCCC	36.07	27149854
424	Phosphorylation	EDPHDEHYLLATQSK CCCCCCHHHEECCCH	11.02	27149854
428	Phosphorylation	DEHYLLATQSKQEQS CCHHHEECCCHHHHH	33.09	28494245
444	Phosphorylation	KATADRKSASKPIGF HHHCCCHHCCCCCCC	38.37	25338131
446	Phosphorylation	TADRKSASKPIGFEG HCCCHHCCCCCCCCC	46.16	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARP8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARP8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARP8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARP8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.