dbPTM

ARP5_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARP5_ARATH
UniProt AC	Q940Z2
Protein Name	Actin-related protein 5
Gene Name	ARP5
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	724
Subcellular Localization	Nucleus . Nucleus, nucleoplasm . Cytoplasm . Localized in the nucleoplasm of interphase cells (PubMed:19679120). However, dispersed into the cytoplasm in dividing cells at metaphase (PubMed:19679120).
Protein Description	Probable subunit of a chromatin-remodeling complex. Involved in DNA repair. Required for multicellular development of all organs..
Protein Sequence	MAFVSRIRRQSDYNTYPSSIPIVIDNGASYFRIGWAGETEPRVVFRNIVQRPRHKATGETVTIVGDLDPSMMKYFDCTRSGPRSPFDSNVVYQFEIMEYILDYAFDRLGANGSGIDHPILITECACNPVQSRSKMAELLFETYGVPAVAFGVDAAFSYKYNQLHGICKKDGIVLCPGFTTTHSIPFVDGEPIYKGSSRTNIGGYHVTDYLKQLLSLKYPFHSSRFTWEKAEDLKLEHCYIAPDYASEIRLFQEGRKEAEEKTSYWQLPWIPPPTEVPPSEEEIARKAAIREKQGQRLREMAEAKRVSKINDMENQLISLRFLLKQVDQVEEDDIPTFLSDTGYASRQELESTITKVTQSLRKARGEPKNEPAEYEENPDSLNNEKYPLMNVPDDILTPEQLKDKKRQMFLKTTAEGRLRARQKRNEEELEKEKRNQLEEERRRENPESYLEELQAQYKEVLERVEQKKRLKTNGSSNGNNKSGGIGRGERLSAAQRERMRLLTTAAFDRGKGEDTFGSRDEDWQLYKLMSKDNDDDDEQPDSDEAELARLSSRLQEIDPTFVQKVEGELSQTSGEVPRVRPLTEEDYKIVIGIERFRCPEILFHPNLIGIDQVGLDEMAGTSIRRLPHDEKELEERLTSSILMTGGCSLLPGMNERLECGIRMIRPCGSPINVVRAMDPVLDAWRGASAFAANLNFLGNAFTKMDYDEKGEDWLRNYQIRYNYL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
412	Phosphorylation	KRQMFLKTTAEGRLR HHHHHHHHHHHHHHH	33.13	19880383
413	Phosphorylation	RQMFLKTTAEGRLRA HHHHHHHHHHHHHHH	22.56	19880383
476	Phosphorylation	RLKTNGSSNGNNKSG HHHCCCCCCCCCCCC	50.59	19880383
542	Phosphorylation	DDDEQPDSDEAELAR CCCCCCCCHHHHHHH	43.99	14593172
570	Phosphorylation	QKVEGELSQTSGEVP HHHHHHHHCCCCCCC	27.40	30407730
572	Phosphorylation	VEGELSQTSGEVPRV HHHHHHCCCCCCCCC	35.01	30407730
573	Phosphorylation	EGELSQTSGEVPRVR HHHHHCCCCCCCCCE	25.89	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARP5_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARP5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARP5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ARP5_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARP5_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana."; Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.; J. Proteomics 72:439-451(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542, SUBCELLULARLOCATION, AND MASS SPECTROMETRY.	19245862 [Abstract]