ARMC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMC2_HUMAN
• UniProt AC: Q8NEN0
• Protein Name: Armadillo repeat-containing protein 2
• Gene Name: ARMC2
• Organism: Homo sapiens (Human).
• Sequence Length: 867
• Protein Sequence: MLSPNDKMLGKLDPFYQPSVSKQKTSAEIISEARNALRTVRTQRPFTPQEAQRKLFGPASSRTSENRPPSSFSLHASSFESSDSRPISGTRLSPLELKPKVPASPTREEDSCFSFPKPPVDPAKIRRVSNARARLFRAASQRALLPDRSLPPSDSKKTVESKETVMMGDSMVKINGIYLTKSNAICHLKSHPLQLTDDGGFSEIKEQEMFKGTTSLPSHLKNGGDQGKRHARASSCPSSSDLSRLQTKAVPKADLQEEDAEIEVDEVFWNTRIVPILRELEKEENIETVCAACTQLHHALEEGNMLGNKFKGRSILLKTLCKLVDVGSDSLSLKLAKIILALKVSRKNLLNVCKLIFKISRNEKNDSLIQNDSILESLLEVLRSEDLQTNMEAFLYCMGSIKFISGNLGFLNEMISKGAVEILINLIKQINENIKKCGTFLPNSGHLLVQVTATLRNLVDSSLVRSKFLNISALPQLCTAMEQYKGDKDVCTNIARIFSKLTSYRDCCTALASYSRCYALFLNLINKYQKKQDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKPVAQQLLNRIQRHHTFLEPLPIPSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	O-linked_Glycosylation	-----MLSPNDKMLG -----CCCCCCCCCC	21.99	30379171
3	Phosphorylation	-----MLSPNDKMLG -----CCCCCCCCCC	21.99	22115753
16	Phosphorylation	LGKLDPFYQPSVSKQ CCCCCCCCCCCCCCC	25.54	22115753
19	Phosphorylation	LDPFYQPSVSKQKTS CCCCCCCCCCCCCCH	24.40	26091039
21	Phosphorylation	PFYQPSVSKQKTSAE CCCCCCCCCCCCHHH	33.43	22115753
104	Phosphorylation	LKPKVPASPTREEDS CCCCCCCCCCCCCCC	22.27	-
218	Phosphorylation	KGTTSLPSHLKNGGD CCCCCCCHHHHCCCC	46.90	17192257
238	Phosphorylation	ARASSCPSSSDLSRL CCHHCCCCHHHHHHH	46.96	-
247	Phosphorylation	SDLSRLQTKAVPKAD HHHHHHHHCCCCHHH	26.09	-
330	Phosphorylation	LVDVGSDSLSLKLAK HCCCCCCCHHHHHHH	22.89	24719451
332	Phosphorylation	DVGSDSLSLKLAKII CCCCCCHHHHHHHHH	27.66	24719451
439	Phosphorylation	ENIKKCGTFLPNSGH HHHHHHCCCCCCCCC	31.31	-
452	Phosphorylation	GHLLVQVTATLRNLV CCEEEEHHHHHHHHH	9.24	-
462	Phosphorylation	LRNLVDSSLVRSKFL HHHHHCHHHHHHHCC	26.81	24719451
499	Phosphorylation	TNIARIFSKLTSYRD HHHHHHHHHHHHHHH	25.12	24719451
557	Phosphorylation	NQAREQFSKEKGSIQ HHHHHHHHHHHHHHH	39.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ARMC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, AND MASSSPECTROMETRY.
PubMed: 18691976