ARLY_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARLY_MOUSE
• UniProt AC: Q91YI0
• Protein Name: Argininosuccinate lyase
• Gene Name: Asl
• Organism: Mus musculus (Mouse).
• Sequence Length: 464
• Protein Sequence: MASESGKLWGGRFVGAVDPIMEKFNSSISYDRHLWNVDVQGSKAYSRGLEKAGLLTKAEMQQILQGLDKVAEEWAQGTFKLHPNDEDIHTANERRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSALLRVLIGTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVQKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMIAVLQVATGVISTLQIHRENMKQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNLLSLQELQTISPLFSGDVSHVWDYSHSVEQYSALGGTAKSSVEWQIRQVRALLQAQEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASESGKLW ------CCCCCCCCC	23.23	23806337
3	Phosphorylation	-----MASESGKLWG -----CCCCCCCCCC	30.88	22324799
5	Phosphorylation	---MASESGKLWGGR ---CCCCCCCCCCCC	38.44	22324799
7	Acetylation	-MASESGKLWGGRFV -CCCCCCCCCCCCCC	50.80	23806337
7	Succinylation	-MASESGKLWGGRFV -CCCCCCCCCCCCCC	50.80	23954790
7	Malonylation	-MASESGKLWGGRFV -CCCCCCCCCCCCCC	50.80	26320211
23	Acetylation	AVDPIMEKFNSSISY CHHHHHHHHHCCCCC	32.25	23954790
23	Ubiquitination	AVDPIMEKFNSSISY CHHHHHHHHHCCCCC	32.25	27667366
27	Phosphorylation	IMEKFNSSISYDRHL HHHHHHCCCCCCCCC	19.36	21743459
29	Phosphorylation	EKFNSSISYDRHLWN HHHHCCCCCCCCCEE	23.95	21743459
30	Phosphorylation	KFNSSISYDRHLWNV HHHCCCCCCCCCEEE	18.48	21743459
43	Ubiquitination	NVDVQGSKAYSRGLE EEECCCCCHHHHHHH	59.16	27667366
43	Malonylation	NVDVQGSKAYSRGLE EEECCCCCHHHHHHH	59.16	26320211
51	Ubiquitination	AYSRGLEKAGLLTKA HHHHHHHHCCCCCHH	53.44	-
51	Malonylation	AYSRGLEKAGLLTKA HHHHHHHHCCCCCHH	53.44	26320211
51	Acetylation	AYSRGLEKAGLLTKA HHHHHHHHCCCCCHH	53.44	23201123
57	Ubiquitination	EKAGLLTKAEMQQIL HHCCCCCHHHHHHHH	42.17	-
57	Malonylation	EKAGLLTKAEMQQIL HHCCCCCHHHHHHHH	42.17	26320211
57	Acetylation	EKAGLLTKAEMQQIL HHCCCCCHHHHHHHH	42.17	22733758
60	Sulfoxidation	GLLTKAEMQQILQGL CCCCHHHHHHHHHHH	4.20	21406390
69	Acetylation	QILQGLDKVAEEWAQ HHHHHHHHHHHHHHH	48.68	22733758
80	Malonylation	EWAQGTFKLHPNDED HHHHCCCCCCCCCHH	45.80	26320211
80	Ubiquitination	EWAQGTFKLHPNDED HHHHCCCCCCCCCHH	45.80	-
80	Acetylation	EWAQGTFKLHPNDED HHHHCCCCCCCCCHH	45.80	23954790
90	Phosphorylation	PNDEDIHTANERRLK CCCHHCHHHCHHHHH	31.35	25521595
94	Ubiquitination	DIHTANERRLKELIG HCHHHCHHHHHHHHH	49.38	27667366
97	Acetylation	TANERRLKELIGEAA HHCHHHHHHHHHHHH	48.97	23806337
97	Ubiquitination	TANERRLKELIGEAA HHCHHHHHHHHHHHH	48.97	27667366
97	Succinylation	TANERRLKELIGEAA HHCHHHHHHHHHHHH	48.97	23806337
97	Malonylation	TANERRLKELIGEAA HHCHHHHHHHHHHHH	48.97	26320211
106	Ubiquitination	LIGEAAGKLHTGRSR HHHHHHHHCCCCCCC	32.16	-
129	S-nitrosylation	RLWMRQTCSKLSALL HHHHHHHHHHHHHHH	2.27	22178444
131	Acetylation	WMRQTCSKLSALLRV HHHHHHHHHHHHHHH	48.91	23864654
131	Malonylation	WMRQTCSKLSALLRV HHHHHHHHHHHHHHH	48.91	26320211
133	Phosphorylation	RQTCSKLSALLRVLI HHHHHHHHHHHHHHH	22.17	22942356
192	Succinylation	ERLLEVQKRINVLPL HHHHHHHHHCCEEEC	61.49	23954790
192	Ubiquitination	ERLLEVQKRINVLPL HHHHHHHHHCCEEEC	61.49	-
192	Malonylation	ERLLEVQKRINVLPL HHHHHHHHHCCEEEC	61.49	26320211
266	Acetylation	DLILYGTKEFSFVQL HHHHHCCCCEEEEEE	53.01	23954790
269	Phosphorylation	LYGTKEFSFVQLSDA HHCCCCEEEEEEHHH	26.12	29472430
274	Phosphorylation	EFSFVQLSDAYSTGS CEEEEEEHHHCCCCC	11.78	29472430
277	Phosphorylation	FVQLSDAYSTGSSLM EEEEHHHCCCCCCCC	16.26	29472430
278	Phosphorylation	VQLSDAYSTGSSLMP EEEHHHCCCCCCCCC	28.19	29472430
279	Phosphorylation	QLSDAYSTGSSLMPQ EEHHHCCCCCCCCCC	28.54	29472430
281	Phosphorylation	SDAYSTGSSLMPQKK HHHCCCCCCCCCCCC	22.01	30352176
282	Phosphorylation	DAYSTGSSLMPQKKN HHCCCCCCCCCCCCC	29.99	29899451
287	Succinylation	GSSLMPQKKNPDSLE CCCCCCCCCCCCHHH	48.96	23954790
288	Acetylation	SSLMPQKKNPDSLEL CCCCCCCCCCCHHHH	69.35	23954790
288	Ubiquitination	SSLMPQKKNPDSLEL CCCCCCCCCCCHHHH	69.35	-
307	S-nitrosylation	AGRVFGRCAGLLMTL HHHHHHHHHHHHHHH	3.44	22178444
323	Succinylation	GLPSTYNKDLQEDKE CCCCCCCCCHHHCHH	49.77	23954790
323	Acetylation	GLPSTYNKDLQEDKE CCCCCCCCCHHHCHH	49.77	23954790
323	Ubiquitination	GLPSTYNKDLQEDKE CCCCCCCCCHHHCHH	49.77	27667366
361	Succinylation	QIHRENMKQALSPDM HHHHHHHHHHCCHHH	43.96	23954790
365	Phosphorylation	ENMKQALSPDMLATD HHHHHHCCHHHHHHH	23.13	23984901
371	Phosphorylation	LSPDMLATDLAYYLV CCHHHHHHHHHHHHH	27.81	28059163
375	Phosphorylation	MLATDLAYYLVRKGM HHHHHHHHHHHHCCC	12.48	28059163
397	Sulfoxidation	ASGKAVFMAETKGVA HCCCEEEEECCHHHH	2.37	21406390
446	Phosphorylation	ALGGTAKSSVEWQIR HCCCCCCHHHHHHHH	36.83	29472430
447	Phosphorylation	LGGTAKSSVEWQIRQ CCCCCCHHHHHHHHH	24.29	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARLY_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
288	K	Acetylation	Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARLY_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARLY_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.