dbPTM

ARC1A_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARC1A_RAT
UniProt AC	Q99PD4
Protein Name	Actin-related protein 2/3 complex subunit 1A
Gene Name	Arpc1a
Organism	Rattus norvegicus (Rat).
Sequence Length	370
Subcellular Localization	Cytoplasm, cytoskeleton .
Protein Description	Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks..
Protein Sequence	MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWTKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGIWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLRTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDVPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLHQFLLE ------CCHHHHHHC	34.26	27097102
21	Phosphorylation	HAWNRDRTQIALSPN EEECCCCCEEEECCC	28.72	-
36	Acetylation	NHEVHIYKKNGSQWT CCEEEEEEECCCCCE	38.88	22902405
63	Acetylation	TGIDWAPKSDRIVTC CCCCCCCCCCCEEEE	58.19	22902405
138	Acetylation	WWVSKHIKKPIRSTV EEEEHHCCCCCCCEE	52.82	22902405
174	Acetylation	RVFSAYIKEVDEKPA EEEEEEEEECCCCCC	38.72	22902405
179	Acetylation	YIKEVDEKPASTPWG EEEECCCCCCCCCCC	41.23	22902405
179	Ubiquitination	YIKEVDEKPASTPWG EEEECCCCCCCCCCC	41.23	-
236	Phosphorylation	SVADASKSVQVSTLR CHHHHCCCEEEEECC	18.45	25403869
298	Phosphorylation	QSIQRNMSAMERFRN HHHHHCHHHHHHHHC	28.19	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARC1A_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARC1A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARC1A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ARC1A_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARC1A_RAT

Related Literatures of Post-Translational Modification