ARAP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARAP1_MOUSE
• UniProt AC: Q4LDD4
• Protein Name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
• Gene Name: Arap1 {ECO:0000312|MGI:MGI:1916960}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1452
• Subcellular Localization: Cytoplasm . Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein . Cell membrane .
• Protein Description: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity)..
• Protein Sequence: MAEGYDAALSVAEWLRALHLEQYTALFEQHGLVWATECQGLSDAGLLDMGMHLPGHRRRILAGLHRAHAPPVPLPRPAPRPVPMKRHIFRSPPVPVTPPEPPPTAGEDEGLPAAPPIPPRRSCLPPACFTPTSTAAPDPVLPPLPAKRHLVEPSVPPVPPRTGPPYPQASLLAKEELLLPSVSPRSQPEPAETPSTLLPAFPQGPLQPPSPPPCPPVIPPKPPRLLPEFDDSDYDDVPEEGPGAPASVMTKEEPLPSRVPRAVRVASLLSEGEELSGDDSEDDDDHAYEGIPNGGWPTSGLNPPLRSLIPDLPLHPMDELPGGPTPITPVIKAGWLDKNPPQGSYIYQKRWVRLDADYLRYFDSNKDAYSKRFVPVACICRVAPIGDQKFEVITNNRTFAFRAESDVERNEWMQALQQAVVEHRARFRLSSASVLGVRGSEQPDRAGSLELRGFKNKLYVAVTGDKVQLYKNLEEFHLGIGITFIDMNVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAAQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTEALIQLFLHLGNGPGNHFWAANVPPSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGVSCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVPRLDSVKPLEKHYSVTLPTVSHSGFLYKTASAGKPLQDRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRASEIVCLAVSPLDTHGFEHTFEVYTEGERLYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPCKAGLSLQQAQEGWFALTGSELRAVFPEGPWEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMAWLGVIQKAAASLGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALISHLYCVQCFSDTNQMNTHNLAIVFGPTLFQTDGQDYKAGKVVEDLINHYVVVFSVDEEELRKQREEVTAIVKMRVAGTASGTQHAGDFICTVYLEEKKVETEQHVKIPASMTAEELTLEILDRRNVSIREKDYWTCFEVNEKEEAERPLHFAEKVLPIVHGLGIDSHLVVKKYQSMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPVKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLSVQHDGLVWPSEPSRVSRAVPEVRMGSVSLIPLRGSENEMRRSVAAFTADPLSLLRHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Acetylation	APRPVPMKRHIFRSP CCCCCCCCCCCCCCC	34.45	15609689
181	Phosphorylation	KEELLLPSVSPRSQP HHHHHCCCCCCCCCC	34.89	26824392
183	Phosphorylation	ELLLPSVSPRSQPEP HHHCCCCCCCCCCCC	20.95	24899341
186	Phosphorylation	LPSVSPRSQPEPAET CCCCCCCCCCCCCCC	54.17	25619855
193	Phosphorylation	SQPEPAETPSTLLPA CCCCCCCCCCCCCCC	25.33	25619855
195	Phosphorylation	PEPAETPSTLLPAFP CCCCCCCCCCCCCCC	38.82	25619855
196	Phosphorylation	EPAETPSTLLPAFPQ CCCCCCCCCCCCCCC	33.25	25619855
210	Phosphorylation	QGPLQPPSPPPCPPV CCCCCCCCCCCCCCC	57.64	26824392
232	Phosphorylation	LLPEFDDSDYDDVPE CCCCCCCCCCCCCCC	39.66	24925903
234	Phosphorylation	PEFDDSDYDDVPEEG CCCCCCCCCCCCCCC	20.28	25619855
250	Phosphorylation	GAPASVMTKEEPLPS CCCCCCCCCCCCCCC	32.90	25619855
389	Acetylation	VAPIGDQKFEVITNN EEECCCCEEEEEECC	48.51	23954790
430	Phosphorylation	HRARFRLSSASVLGV HHHHHHCCCCEEEEC	21.43	26824392
431	Phosphorylation	RARFRLSSASVLGVR HHHHHCCCCEEEECC	29.20	23984901
433	Phosphorylation	RFRLSSASVLGVRGS HHHCCCCEEEECCCC	21.59	21183079
499	Phosphorylation	VKEVDRRSFDLTTPY CCEEEHHCCCCCCCE	24.81	29176673
506	Phosphorylation	SFDLTTPYRIFSFSA CCCCCCCEEEEECCC	17.78	-
723	Phosphorylation	EFLRNNQSTEVPRLD HHHHCCCCCCCCCCC	28.76	25367039
724	Phosphorylation	FLRNNQSTEVPRLDS HHHCCCCCCCCCCCC	31.10	25367039
731	Phosphorylation	TEVPRLDSVKPLEKH CCCCCCCCCCCHHHC	36.31	29514104
739	Phosphorylation	VKPLEKHYSVTLPTV CCCHHHCEEEECCCC	18.86	29472430
740	Phosphorylation	KPLEKHYSVTLPTVS CCHHHCEEEECCCCC	14.35	26824392
742	Phosphorylation	LEKHYSVTLPTVSHS HHHCEEEECCCCCCC	22.53	29472430
745	Phosphorylation	HYSVTLPTVSHSGFL CEEEECCCCCCCCEE	37.44	29472430
747	Phosphorylation	SVTLPTVSHSGFLYK EEECCCCCCCCEEEE	17.89	20531401
749	Phosphorylation	TLPTVSHSGFLYKTA ECCCCCCCCEEEEEC	24.59	20531401
753	Phosphorylation	VSHSGFLYKTASAGK CCCCCEEEEECCCCC	12.20	-
793	Phosphorylation	YENERAVTPNGEIRA CCCCCCCCCCCCEEH	15.28	-
933	Phosphorylation	VLVERRRTLYIQGER EEEEECCEEEECCCH	23.31	25168779
935	Phosphorylation	VERRRTLYIQGERRL EEECCEEEECCCHHH	7.21	25168779
977	Phosphorylation	SDIPVIVYRCVDYIT CCCCEEEEEHHHHHH	6.28	-
1215	Phosphorylation	ILDRRNVSIREKDYW HHHHCCCCCCCCCCE	21.34	27555448
1410	Phosphorylation	WPSEPSRVSRAVPEV CCCCCCCHHHCCCCE	5.50	24719451
1419	Phosphorylation	RAVPEVRMGSVSLIP HCCCCEECCCEEEEE	5.92	24719451
1421	Phosphorylation	VPEVRMGSVSLIPLR CCCEECCCEEEEECC	10.13	27180971
1423	Phosphorylation	EVRMGSVSLIPLRGS CEECCCEEEEECCCC	23.44	29472430
1430	Phosphorylation	SLIPLRGSENEMRRS EEEECCCCHHHHHHH	30.71	29472430
1437	Phosphorylation	SENEMRRSVAAFTAD CHHHHHHHHHHHHCC	13.02	27180971

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARAP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARAP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARAP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARAP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.