AQP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AQP4_HUMAN
• UniProt AC: P55087
• Protein Name: Aquaporin-4
• Gene Name: AQP4
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system..
• Protein Sequence: MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	S-palmitoylation	TARRWGKCGPLCTRE CCCCCCCCCCCCCCC	6.30	-
17	S-palmitoylation	WGKCGPLCTRENIMV CCCCCCCCCCCCCEE	3.66	-
111	Phosphorylation	MVCTRKISIAKSVFY HHCCCCHHHHHHHHH	21.38	-
153	N-linked_Glycosylation	GVTMVHGNLTAGHGL CEEEEECCEECCCCH	21.24	UniProtKB CARBOHYD
180	Phosphorylation	TIFASCDSKRTDVTG HHHHCCCCCCCCCCH	28.50	22817900
206	N-linked_Glycosylation	IGHLFAINYTGASMN HHHEEEECCCCCCCC	25.53	UniProtKB CARBOHYD
273	Phosphorylation	FSKAAQQTKGSYMEV HHHHHHHCCCCCEEE	25.87	25307156
276	Phosphorylation	AAQQTKGSYMEVEDN HHHHCCCCCEEECCC	23.90	11742978
277	Phosphorylation	AQQTKGSYMEVEDNR HHHCCCCCEEECCCC	13.13	24927040
285	Phosphorylation	MEVEDNRSQVETDDL EEECCCCHHCCCCCE	44.85	11742978
289	Phosphorylation	DNRSQVETDDLILKP CCCHHCCCCCEEECC	35.64	24076635
295	"N6,N6-dimethyllysine"	ETDDLILKPGVVHVI CCCCEEECCCEEEEE	32.50	-
295	Methylation	ETDDLILKPGVVHVI CCCCEEECCCEEEEE	32.50	-
316	Phosphorylation	EKKGKDQSGEVLSSV CCCCCCCCCCCCCCC	47.24	11742978
321	Phosphorylation	DQSGEVLSSV----- CCCCCCCCCC-----	33.94	23911959
322	Phosphorylation	QSGEVLSSV------ CCCCCCCCC------	27.90	23911959

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
111	S	Phosphorylation	Kinase	PKG	-	Uniprot
180	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
180	S	Phosphorylation	Kinase	PKC	-	Uniprot
276	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
276	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
276	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
285	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
285	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
316	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
316	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
111	S	Phosphorylation	Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40% (By similarity).	-
180	S	Phosphorylation	Phosphorylation by PKC at Ser-180 reduces conductance by 50%.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AQP4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AQP4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.