APOC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APOC4_HUMAN
• UniProt AC: P55056
• Protein Name: Apolipoprotein C-IV
• Gene Name: APOC4
• Organism: Homo sapiens (Human).
• Sequence Length: 127
• Subcellular Localization: Secreted.
• Protein Description: May participate in lipoprotein metabolism..
• Protein Sequence: MSLLRNRLQALPALCLCVLVLACIGACQPEAQEGTLSPPPKLKMSRWSLVRGRMKELLETVVNRTRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFLESKDSLLKKTHSLCPRLVCGDKDQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	EAQEGTLSPPPKLKM HHHCCCCCCCCCCCH	34.89	24719451
63	N-linked_Glycosylation	ELLETVVNRTRDGWQ HHHHHHHHHCCCCCC	34.96	16335952
63	N-linked_Glycosylation	ELLETVVNRTRDGWQ HHHHHHHHHCCCCCC	34.96	16335952
107	Phosphorylation	WFLESKDSLLKKTHS HHHHCHHHHHHHHHH	39.06	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APOC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APOC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APOC4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of APOC4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63, AND MASS SPECTROMETRY.
PubMed: 16335952