| UniProt ID | APOB_RAT | |
|---|---|---|
| UniProt AC | Q7TMA5 | |
| Protein Name | Apolipoprotein B-100 | |
| Gene Name | Apob | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 4743 | |
| Subcellular Localization | Cytoplasm . Secreted . | |
| Protein Description | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.. | |
| Protein Sequence | MGPQRPALRAPLLLLFLLLFLDTSVWAQDATRFKHLRKYVYSYEAESSSGVRGTADSRSATKINCKVELEVPQVCTLIMRTSQCTLKEVYGFNPEGKALMKKTKNSEEFASAMSRYELKLAFPEGKRVALYPDLGEPNYILNIKRGIISALLVPPETEEDKQVLFQDTVYGNCSTQVTVNSRKGTVATEMSTERNLQHCDGFQPISTSVSPLALIKGLVRPLSTLISSSQSCQYTLEPKRKHVSEAICNEQHLFLPFSYKNKYGIMTHVTQKLSLEDTPKINSRFFRGGINQVGLAFESTKSTSPPKQADAVLKTLQELKKLSISEQNAQRANLFHKLVTELRGLSGEAITSLLPQLIEVSSPITLQALIQCGQPECYTHILQWLKTEKAHPLLIDIVTYLMALIPNPSVQRLQEIFNTAKELQSRATLYALSHAVNSYYAIMDHSRSPVLEDIAGYLMKQIDNECMGDEDRTFLILRVIGNMGRTMERVMPALKSSVLNCVRSTKPSLQIQKAALQALRKMEMGDEVRTILFDTFVNDVAPVEKRLAAYLLLMRSPSSSDINKIAKLLQWEQSEQVKNFVASHIANILNSEELYVQDLKNLIKNALVNSRLPTIMDFRKFSRNYQISKSVSIPLFDPVSAKIEGNLVFDPSSYLPKESMLKTTLTVFGIASLDLFEIGLEGKGFEPTLEALFGKQGFFPDSVNKALYWVNGQVPDRVSKVLVDHFGYTKDDKHEQDMVNGIMPIVDKLIKELKSKEIPEARAYLRILGKELGFVRLQDLQVLGKLLLNGAQTFRGVPQMIVQAIREGSKDDLFLHYIFMENAFELPTGVGLQLQVSSSGVFTPGIKAGVRLELANIQAELVAKPSVSLEFVTNMGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLFSGSNTLHLVSTTKTEVIPPLIENRKSWSTCKPFFTGMNYCTTGAYSNASSTESASYYPLTGDTRYELELKPTGEVEQYSASATYELLKEDKSLVDTLKFLVQAEGVQQSEATAMFKYNRRSRTLSSEVLIPGFDVNFGTILRVNDESSKDKNTYKLILDIQNKKITEVSVVGHVSYDKKGDGKVKGVVSIPRLQAEARSEVHTHWSPTKLLFQMDSSATAYGSTISKRVAWRYDNEKIEFDWNTGTNVDTKKVASNFPVDLSRYPRMVHEYANGLLDHRVPQTDMTFRHMGSKLIVDHLNGLSELNLPKVGLPDFHIPDNLFLKTDGRVKYTLNKNRIEIDIPLPLGGKSSKDLKVPESVRTPALNFKSVGFHLPSQEVQIPTFTIPKTHQLQVPLLGILDLSTNVYSNLYNWSVSYTGGNTSRDHFSLQAQYRMKADSVVDLFSYSVQGSGETTYDSKSTFTLSCDGSLHHKFLDSKFKVSHVEKFGNNPVSKGLLTFETSSALGPQMSATVQLDSKKKQHLYVKDIKVDGQFRVFSLYAQGEYGLSYERDSMTGQMSGESNMKFNSTYFQGTNQIVGMYQDGMLSVTSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFAASNKLDMTFSKQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHKSTLKIAQDGVSTSATTNLKYSPLLLENELNAELGLSGASMKLSTSGRFKEHHAKFSLDGRAALTEVSLGSIYQAMILGADSKNVFNFKLSREGLKLSNDMMGSYAEMKLDHTHSLRISGLSLDFFSKMDNIYSGDKFYKQNFNLQLQPYSFGITLSNDLKYDALVLTNNGRLRLEPLKLNVGGNFKGTYQNNELKHIYTISYTDLVVASYRADTVATVQGVEFSHRLNADIEGLASSVDVTTSYSSDPLHFNNVFRFVLAPFTLGVDTHTSGDGKMSLWGEHTGQMYSKFLLKAEPLALTFSHDYKGSTSHNLLYKNSVSTALEHTLSALLTPAEQTSSWKFKTSLNDKVYSQEFEAYNTKDKIGIELSGRADLSGLYSPIKVPFFYSEPVNVLNSLEINDAFDEPREFTIDAVVKYDKNQDVHTISLPFFQSLPDYLERNRRGIISLLEAMKGELQRLSVDQFVRKYRVALSRLPQQIHDYLNASDWERQVAGAKEKLTSFMENYRITDNDVLIALDSAKINLNEKLSQLETYAIQFDQYIRDNYDAQDLKRTIAQIIDRIIEKLKMLDEQYHIRVNLAKSIHNLYLFVENVDLNQISSSGASWIQNVDTKYQIRIQIQEKLQHLRTQIHNIDIQQLAAELKQQIEALDVPMHLDQLRTAILFQRISVIIERVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDRQIQVLMDKSIELAHRYSLSEPLQKLSNVLQQIEIKDYYDKLVGFIDDTVEWIKAVSFKNIIEELNRLIDMSVKKLKAFDYHQFVDKTNSKIREMTQRINAEIQALELPQKTEALKLWVEDFKTTVSNSLEKLKDTKVTVVVDWLQDGLAQIKAQFQDALEDVRDRIYQMDIQGELERCLSLVSQVYSTVVTYISDWWTLTAKNITDFAEQYSTQKWAESVKALVEQGFIVPEIQTFLGTMPAFEVSLHALQEANFQTPDFIVPLTDLRIPSIWINFKMLKNVKIPLRFSTPEFTLLNTFRVRSFTIDLLEIKAKIIRTIDQMLSSELQWPLPEVYLRDLEMVNISLARLSLPDFHVPEITIPEFTIPNVNLKDLQVPDLHIPEFQLPHLSCTTEIPAFGKLHSVLKIQSPLFILDASANIQNITTSENKAEIVASVTARGESKFEALNFDFQAQAQFLELNANPLVLKESVNFSSKHVRMEHEGKILVSGKALEGKSDTVARLHTEKNTVEFNNGIVVKINNQFTLDSQTKYFHKLSVPRLDFSSKASLNNEIKTLLEAGHMAWTSSGTGSWNWACPNFSDEGIHSSKISFIVDGPIASFGLSNNINGKHLRVVQKLTSESGFLNYSRFEVESKVESQHVGSSILTAEGRALLGDAKAEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVSFPLKLTGKIDFLNNYALFLSPHAQQASWQLSTRFNQYKYNQNFSAINNEHNMEASIVMNGDANLDFLNIPLTIPEINLPYTRFTTPLLKDFSIWEETGLKEFLKTTKQSFDLSIKAQYKKNRDKHSVVIPLKMFYEFMLNNVNSWDRKFEKVRDNALHFLTASYNETKIKFDKYKTENSLNQPSRTFQNRGHTIPVLNIEVSPFAVETLASSHVIPKAIRTPSVTIPGPNIIVPSYRLVLPSLQLPVFHIPRTLFKFSLPDFKKLSTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDLVARFLSSSSFVTDALQYKLEGTSRLMRKKVLKLATAVSLTNKFLKGSHDSTISLTKKNMEASVKTTANLHAPIFTMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSAAKGGVDHKFSLESLTSYLSIESFTKGNIKGSFLSQEYSGSVANEANVYLNSKGTRSSVRLQGASNFAGIWNFEVGENFAGEATLRRIYGTWEHNMINHLQVFSYFDTKGKQTCRATLELSPWTMSTLLQVHVSQPSPLFDLHHFDQEVILKASTKNQKVSWKSEVQVESQVLQHNAHFSNDQEEVRLDIAGSLEGQLWDLENFFLPAFGKSLRELLQIDGKRQYLQASTSLHYTKNPNGYLLSLPVQELTDRFIIPGLKLNDFSGIKIYKKLSTSPFALNLTMLPKVKFPGVDLLTQYSKPEGSSVPTFETTIPEIQLTVSQFTLPKSFPVGNTVFDLNKLTNLIADVDLPSITLPEQTIEIPSLEFSVPAGIFIPFFGELTAHVGMASPLYNVTWSTGWKNKADHVETFLDSTCSSTLQFLEYALKVVGTHRIENDKFIYKIKGTLQHCDFNVKYNEDGIFEGLWDLEGEAHLDITSPALTDFHLHYKEDKTSVSASAASPAIGTVSLDASTDDQSVRLNVYFRPQSPPDNKLSIFKMEWRDKESDGETYIKINWEEEAAFRLLDSLKSNVPKASEAVYDYVKKYHLGHASSELRKSLQNDAEHAIRMVDEMNVNAQRVTRDTYQSLYKKMLAQESQSIPEKLKKMVLGSLVRITQKYHMAVTWLMDSVIHFLKFNRVQFPGNAGTYTVDELYTIAMRETKKLLSQLFNGLGHLFSYVQDQVEKSRVINDITFKCPFSPTPCKLKDVLLIFREDLNILSNLGQQDINFTTILSDFQSFLERLLDIIEEKIECLKNNESTCVPDHINMFFKTHIPFAFKSLRENIYSVFSEFNDFVQSILQEGSYKLQQVHQYMKAFREEYFDPSVVGWTVKYYEIEEKMVDLIKTLLAPLRDFYSEYSVTAADFASKMSTQVEQFVSRDIREYLSMLADINGKGREKVAELSIVVKERIKSWSTAVAEITSDYLRQLHSKLQDFSDQLSGYYEKFVAESTRLIDLSIQNYHMFLRYIAELLKKLQVATANNGLLKRGDFEAAVKLGIACLYNEGLSVSDEAYAEVNGLKASRFFSMDERLNMGSDPFIWLSICPPCFRKLRDFAGKGCWEAQPALAKDCAGGSQLGLEGKAFSESVCQLFQASQAVNKQQIFSVQKGLSDTVRYILIGWLVEVAPMKDFTSLCLHLTVECVGRYLQRKLVPRYKLQLLGIACMVICTWFISKEILTIREAVRLTDNTYKYKDLVRVKREIISALEGKIRIPTVVDYKEVLLTLVPVTPRTQYLCSFLCELTLSVYTPAHLASAALLLARLMHGQTQP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 126 | Acetylation | KLAFPEGKRVALYPD HHHCCCCCEEEEECC | 41.88 | 22902405 | |
| 172 | N-linked_Glycosylation | FQDTVYGNCSTQVTV ECCCCCCCCEEEEEE | 10.01 | - | |
| 486 | Phosphorylation | VIGNMGRTMERVMPA HHCCCCHHHHHHHHH | 20.04 | 22673903 | |
| 630 | Phosphorylation | RNYQISKSVSIPLFD HCCCCCCCEECCCCC | 17.82 | 30181290 | |
| 632 | Phosphorylation | YQISKSVSIPLFDPV CCCCCCEECCCCCCC | 26.11 | 30181290 | |
| 971 | N-linked_Glycosylation | CTTGAYSNASSTESA CCCCCCCCCCCCCEE | 31.03 | - | |
| 1090 | Phosphorylation | DIQNKKITEVSVVGH EECCCCCEEEEEEEE | 38.93 | 26022182 | |
| 1093 | Phosphorylation | NKKITEVSVVGHVSY CCCCEEEEEEEEEEE | 12.59 | 26022182 | |
| 1100 | Phosphorylation | SVVGHVSYDKKGDGK EEEEEEEEECCCCCC | 30.60 | 26022182 | |
| 1336 | N-linked_Glycosylation | NVYSNLYNWSVSYTG CCHHHCCEEEEEECC | 27.93 | - | |
| 1345 | N-linked_Glycosylation | SVSYTGGNTSRDHFS EEEECCCCCCCCEEE | 35.90 | - | |
| 1491 | N-linked_Glycosylation | GESNMKFNSTYFQGT CCCCCEEECEEECCC | 28.11 | - | |
| 1771 | Phosphorylation | TLSNDLKYDALVLTN ECCCCCCCCEEEEEC | 17.47 | - | |
| 1887 | Phosphorylation | TSGDGKMSLWGEHTG CCCCCCCCEECCCHH | 25.18 | - | |
| 1973 | Acetylation | EAYNTKDKIGIELSG EECCCCCCCCEEECC | 44.37 | - | |
| 2006 | Phosphorylation | EPVNVLNSLEINDAF CCCCHHHCCEECCCC | 24.18 | 22673903 | |
| 2094 | N-linked_Glycosylation | QQIHDYLNASDWERQ HHHHHHHCCHHHHHH | 31.04 | - | |
| 2522 | N-linked_Glycosylation | WWTLTAKNITDFAEQ HHHEEEHHHHHHHHH | 39.67 | - | |
| 2662 | N-linked_Glycosylation | LRDLEMVNISLARLS HCHHHHEEEEEEECC | 19.47 | - | |
| 2741 | N-linked_Glycosylation | DASANIQNITTSENK ECCCCCEECCCCCCH | 29.76 | - | |
| 2791 | N-linked_Glycosylation | LVLKESVNFSSKHVR EEEEECCCCCCCCCC | 40.12 | - | |
| 2897 | N-linked_Glycosylation | SWNWACPNFSDEGIH CCCCCCCCCCCCCCC | 49.27 | - | |
| 2944 | N-linked_Glycosylation | TSESGFLNYSRFEVE HCCCCCCCCEEEEEE | 30.39 | - | |
| 3063 | N-linked_Glycosylation | NQYKYNQNFSAINNE HHHCCCCCCCCCCCC | 29.24 | - | |
| 3106 | Phosphorylation | LPYTRFTTPLLKDFS CCCCCCCCHHHCCCC | 14.82 | 26022182 | |
| 3186 | N-linked_Glycosylation | HFLTASYNETKIKFD HHHHCCCCCCEEECC | 48.22 | - | |
| 3299 | N-linked_Glycosylation | IYIPAMGNFTYDFSF EEECCCCCEEEEEEE | 17.01 | - | |
| 3321 | N-linked_Glycosylation | NTNAGLYNQSDLVAR ECCCCCCCHHHHHHH | 39.66 | - | |
| 3428 | N-linked_Glycosylation | IELNYDFNSSKLHSA EEEEECCCHHHHHHH | 42.34 | - | |
| 3715 | N-linked_Glycosylation | STSPFALNLTMLPKV CCCCCCCCCCCCCCC | 30.00 | - | |
| 3828 | N-linked_Glycosylation | GMASPLYNVTWSTGW CCCCCCCEECCCCCC | 32.21 | - | |
| 3981 | Phosphorylation | MEWRDKESDGETYIK EEEECCCCCCCEEEE | 57.57 | - | |
| 3985 | Phosphorylation | DKESDGETYIKINWE CCCCCCCEEEEEECC | 35.76 | - | |
| 4203 | N-linked_Glycosylation | NLGQQDINFTTILSD HCCCCCCCHHHHHHH | 36.18 | - | |
| 4232 | N-linked_Glycosylation | KIECLKNNESTCVPD HHHHHHCCCCCCCCH | 42.90 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of APOB_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of APOB_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of APOB_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of APOB_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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