APLP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APLP2_MOUSE
• UniProt AC: Q06335
• Protein Name: Amyloid-like protein 2
• Gene Name: Aplp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 707
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Nucleus .
• Protein Description: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity). Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts..
• Protein Sequence: MAATGTAAAAATGKLLVLLLLGLTAPAAALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKRQCKSHIVIPFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQTKTVDSDSTMSKEEEEEEEDEEDEEEDYDLDKSEFPTEADLEDFTEAAADEEEEDEEEGEEVVEDRDYYYDPFKGDDYNEENPTEPSSEGTISDKEIVHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKTERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTSSISENPVDVRVSSEESEEIPPFHPLHPFPSLSENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVINSKNKMDENMVIDETLDVKEMIFNAERVGGLEEEPESVGPLREDFSLSSNALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
208	Phosphorylation	VCCPQTKTVDSDSTM EECCCCEECCCCCCC	32.69	23737553
211	Phosphorylation	PQTKTVDSDSTMSKE CCCEECCCCCCCCHH	29.17	25195567
213	Phosphorylation	TKTVDSDSTMSKEEE CEECCCCCCCCHHHH	29.93	25521595
214	Phosphorylation	KTVDSDSTMSKEEEE EECCCCCCCCHHHHH	30.38	25521595
216	Phosphorylation	VDSDSTMSKEEEEEE CCCCCCCCHHHHHHH	36.68	25521595
485	N-linked_Glycosylation	HVIEERRNQSLSLLY HHHHHHHCCCHHHHH	41.85	-
533	Phosphorylation	NPVDVRVSSEESEEI CCCEEEECCCCCCCC	22.82	19060867
534	Phosphorylation	PVDVRVSSEESEEIP CCEEEECCCCCCCCC	42.39	21183079
537	Phosphorylation	VRVSSEESEEIPPFH EEECCCCCCCCCCCC	36.16	19060867
665	Phosphorylation	VMLRKRQYGTISHGI HHHHHCCCCCCCCCE	21.92	30635358
667	Phosphorylation	LRKRQYGTISHGIVE HHHCCCCCCCCCEEE	17.86	30635358
669	Phosphorylation	KRQYGTISHGIVEVD HCCCCCCCCCEEEEC	18.59	30635358
680	Phosphorylation	VEVDPMLTPEERHLN EEECCCCCHHHHHHH	23.54	20415495
688	Ubiquitination	PEERHLNKMQNHGYE HHHHHHHHHHHCCCC	48.50	-
694	Phosphorylation	NKMQNHGYENPTYKY HHHHHCCCCCCCHHH	12.65	26032504
698	Phosphorylation	NHGYENPTYKYLEQM HCCCCCCCHHHHHHH	44.20	26643407
699	Phosphorylation	HGYENPTYKYLEQMQ CCCCCCCHHHHHHHC	10.01	25263469
700	Ubiquitination	GYENPTYKYLEQMQI CCCCCCHHHHHHHCC	45.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APLP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APLP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APLP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of APLP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.