dbPTM

APC_XENLA - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	APC_XENLA
UniProt AC	P70039
Protein Name	Adenomatous polyposis coli homolog
Gene Name	apc
Organism	Xenopus laevis (African clawed frog).
Sequence Length	2829
Subcellular Localization
Protein Description	Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator..
Protein Sequence	MAAASYDQLVKQVEALTMENTNLRQELEDNSNHLTKLETEATNMKEVLKQLQGSIEDEAMASSGPIDLLERFKDLNLDSSNIPAGKARPKMSMRSYGSREGSLSGHSGECSPVPVGSFQRRGLLNGSRESAGYMEELEKERLLLIAEHEKEEKEKRWYYAQLQNLTKRIDSLPLTENFSMQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRVQTRVGKIHQIEEEILRIRQLLQSQVAEAAERTPQSKHDAGSRDAEKLPDGQGTSEITASGNVGSGQGSSSRADHDTTSVMSSNSTYSVPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCIAMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARASGSAALDNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLINDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKSCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALDVKKESTLKSVLSALWNLSAHCTENKADICSVDGALAFLVSTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNAKDQEGLWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSVPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTTHRNKQRHKQNLCSEYALDSSRHDDSICRSDNFSIGNLTVLSPYINTTVLPGSSSPRPTMDGSRPEKDRERTAGLGNYHSTTESSGNSSKRIGIQLSTTAQISKVMDEVSNIHLVQENRSSGSASEMHCMSDERNSQRKPSSNHPQSNPFTFTKAESSTRGCPVAFMKMEYKMASNDSLNSVSSTEGYGKRGQVKPSVESYSEDDESKFFSYGQYPAGLAHKIQSANHMDDNDTELDTPINYSLKYSDEQLNSGRQSPTQNERWSRPKHIIDSEMKQSEQRQPRTTKTTYSSYTENKEEKHKKFPPHFNQSENVPAYTRSRGANNQVDQSRVSSNLSNNSKASKPHCQVDDYDDDKTTNFSERYSEEEQQEDETERQNKYNIKAYASEEHHGEQPIDYSRKYSTDVPSSAQKPSFPYSNNSSKQKPKKEQVSSNSNTPTPSPNSNRQNQLHPNSAQSRPGLNRPKQIPNKPPSINQETIQTYCVEDTPICFSRGSSLSSLSSAEDEIEGRERNSRGQESNNTLQITEPKEISAVSKDGAVNETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSGSSLDSFESHSIASSIASSVASEHMISGIISPSDLPDSPGQTMPPSRSKTPPPPQTVQAKKDGSKPIVPDEERGKVAKTAVHSAIQRVQVLQEADTLLHFATESTPDGFSCASSLSALSLDEPYIQKDVQLKIMPPVLENDQGNKAEPEKEFIDNKAKKEDKRSEQEKDMLDDTDDDIDILEECIISAMPRKPSRKNKKVPQPTPGKPPPPVARKPSQLPVYKLLSSQNRLQTQKHVNFTHSDDMPRVYCVEGTPINFSTATSLSDLTIESPPSEPTNDQPNTDSLSTDLEKRDTIPTEGRSTDDTDASKPLNPTTVLDEDKAEEGDILAECIHSAMPKGKSHKPYRVKKIMDQINHTSAATSSGNSRSMQETDKNKPTSPVKPMPQSIGFKERLKKNTELKLNPNSENQYCDPRKPSSKKPSKVANEKIPNNEERTKGFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFEDDDIDLSKEKAELRKEKGTKDTDQKVKYKHENRAINPMGKQDQTGPKSLGGRDQPKALVQKPTSFSSAAKGTQDRGGATDEKMENFAIENTPVCFSRNSSLSSLSDIDQENNNKETEPLKQTGTSETQLGLRRPQTSGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKRKPSKIKNEVGKSRSNSVGGILAEEPDLTLDLRDIQSPDSENAFSPDSENFDWKAIQEGANSIVSRLHQAAAAGSLSRQGSSDSDSILSLKSGISLGSPFHLTLDKEEKTITSNKGPKILKPAEKSALENKKTEEEPKGIKGGKKVYKSLITGKSRSSSDFSSHCKQSVQTNMPSISRGRTMIHIPGVRASSPSTSPVSKKGPVFKNVPSKGSNENPSSSSSPKGTKPLKSELVYGSRPSSTPGGSSKGNSRSGSRDSASSRPSPQPLSRPLQSPGRNSISPGKNGISPPNKFSQLPRTTSPSTASTKSSGSGRMSYTSPGRQLSQPNLSKQSGLPKTHSSIPRSESASKSLNQNVNTGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESASFESLSSSSRADSPPRSQTQTPALSPSLPDMALSTHSIQAGGWRKMPPNLNPAAEHGDSRRRHDISRSHSESPSRLPITRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKQQVCSFPGPRSECSSSAKGTWRKIKESEILETPSNGSSSTIAESNCSLESKTLVYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNSPPVIDNVLDQGQKEEAAKDCHTRHNSGNGNVPLLENRQKSFIKVDGLDTKGTDPKSLINNQQETNENTVAERTAFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSNGENSTSRPSQIPTPVTNSTKKRDSKTETTDSSGSQSPKRHSGSYLVTSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of APC_XENLA !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of APC_XENLA !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of APC_XENLA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of APC_XENLA !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of APC_XENLA !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of APC_XENLA

Related Literatures of Post-Translational Modification