AP3D_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP3D_ARATH
• UniProt AC: Q9C744
• Protein Name: AP-3 complex subunit delta
• Gene Name: DELTA-ADR
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 869
• Subcellular Localization: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Localizes also to a novel cellular compartment, the 'delta compartment', characterized by colocalization of EPSIN2 and DELTA-ADR.
• Protein Description: Part of the AP-3 complex, an adaptor-related complex which seems to be clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. It also function in maintaining the identity of lytic vacuoles and in regulating the transition between storage and lytic vacuoles..
• Protein Sequence: MSSSSTSIMDNLFQRSLEDLIKGFRLQLLGESNFISRAVEEIRREIKATDLSTKSTALHKLSYLAALHGVDMSWAAFHAVEVVSSSRFQHKRIGYQAITQSFNDQTSVMLLITNQVRKDLNSANEYEVSLALECLSRIGTHDLARDLTPEVFTLLGSSKSFVKKKAIGVVLRVFEKYHDAVKVCFKRLVENLETSDPQILSAVVGVFCELATKDPQSCLPLAPEFYKVLVDSRNNWVLIKVLKIFAKLALIEPRLGKKVAEPICEHMRRTVAKSLVFECVRTVVSSLSDNEAAVKLAVAKIREFLVEDDPNLKYLGLNALSIVAPKHLWAVLENKEVVVKAMSDEDPNVKLEALHLLMAMVNEDNVSEISRILMNYALKSDPLFCNEIIFSVLSACSRNAYEIIVDFDWYLSLLGEMARIPHCQRGEDIEHQLIDIGMRVRDARPQLVRVSWALLIDPALLGNLFLHPILSAAAWVSGEYVEFSKNPYETVEALLQPRTDLLPPSIKAIYIHSAFKVLVFCLGSYFSSQEPTSSSLAQESSSGSLLVNVFTHESILSLVNVIELGLGPLSGYHDVEVQERAKNVLGYISVIKQEIAEQLNLQDNETEASRVTAFMEDVFSEEFGPISATAQEKVCVPDGLELKENLGDLEEICGEHLKPVESDSVSYTDKISFSVSKLRIRDQQEATSSSSPPHEASSLLAEHRKRHGMYYLTSQKEDQDSNGTSSDYPLANELANEISQDSFNPKRKPNQSKPRPVVVKLDDGDESRITPQAKTNIQTANDDESLSRAIQSALLVKNKGKEKDRYEGNPNSGQQEKEESSRIENHQNSEKKKKKKKKKKGEGSSKHKSRRQNEVASASEQVIIPDFLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSSSTSIM ------CCCCHHHHH	38.64	22223895
52	Phosphorylation	EIKATDLSTKSTALH HHHCCCCCCHHHHHH	36.28	24894044
687	Phosphorylation	IRDQQEATSSSSPPH ECCCHHHCCCCCCCH	28.52	27643528
688	Phosphorylation	RDQQEATSSSSPPHE CCCHHHCCCCCCCHH	34.96	29654922
689	Phosphorylation	DQQEATSSSSPPHEA CCHHHCCCCCCCHHH	30.40	27643528
690	Phosphorylation	QQEATSSSSPPHEAS CHHHCCCCCCCHHHH	46.78	27643528
691	Phosphorylation	QEATSSSSPPHEASS HHHCCCCCCCHHHHH	44.38	30407730
697	Phosphorylation	SSPPHEASSLLAEHR CCCCHHHHHHHHHHH	20.66	27643528
698	Phosphorylation	SPPHEASSLLAEHRK CCCHHHHHHHHHHHH	34.16	27643528
785	Phosphorylation	QTANDDESLSRAIQS CCCCCHHHHHHHHHH	38.34	30407730
787	Phosphorylation	ANDDESLSRAIQSAL CCCHHHHHHHHHHHH	29.01	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP3D_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP3D_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP3D_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of AP3D_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.