AP2D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP2D_HUMAN
• UniProt AC: Q7Z6R9
• Protein Name: Transcription factor AP-2-delta
• Gene Name: TFAP2D {ECO:0000312|HGNC:HGNC:15581}
• Organism: Homo sapiens (Human).
• Sequence Length: 452
• Subcellular Localization: Nucleus .
• Protein Description: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity)..
• Protein Sequence: MSTTFPGLVHDAEIRHDGSNSYRLMQLGCLESVANSTVAYSSSSPLTYSTTGTEFASPYFSTNHQYTPLHHQSFHYEFQHSHPAVTPDAYSLNSLHHSQQYYQQIHHGEPTDFINLHNARALKSSCLDEQRRELGCLDAYRRHDLSLMSHGSQYGMHPDQRLLPGPSLGLAAAGADDLQGSVEAQCGLVLNGQGGVIRRGGTCVVNPTDLFCSVPGRLSLLSSTSKYKVTIAEVKRRLSPPECLNASLLGGILRRAKSKNGGRCLREKLDRLGLNLPAGRRKAANVTLLTSLVEGEALHLARDFGYTCETEFPAKAVGEHLARQHMEQKEQTARKKMILATKQICKEFQDLLSQDRSPLGSSRPTPILDLDIQRHLTHFSLITHGFGTPAICAALSTFQTVLSEMLNYLEKHTTHKNGGAADSGQGHANSEKAPLRKTSEAAVKEGKTEKTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
152	Phosphorylation	LSLMSHGSQYGMHPD HHHHCCCCCCCCCCC	18.14	32142685
154	Phosphorylation	LMSHGSQYGMHPDQR HHCCCCCCCCCCCCC	20.36	32142685
167	Phosphorylation	QRLLPGPSLGLAAAG CCCCCCCCCCHHCCC	40.77	46164843
208	Phosphorylation	GTCVVNPTDLFCSVP CEEEECCCCCCCCCC	39.88	30576142
213	Phosphorylation	NPTDLFCSVPGRLSL CCCCCCCCCCCCHHH	24.82	30576142
219	Phosphorylation	CSVPGRLSLLSSTSK CCCCCCHHHCCCCCC	26.38	24732914
222	Phosphorylation	PGRLSLLSSTSKYKV CCCHHHCCCCCCEEE	36.54	25159151
223	Phosphorylation	GRLSLLSSTSKYKVT CCHHHCCCCCCEEEE	36.35	29255136
224	Phosphorylation	RLSLLSSTSKYKVTI CHHHCCCCCCEEEEH	26.34	23663014
225	Phosphorylation	LSLLSSTSKYKVTIA HHHCCCCCCEEEEHH	35.62	30576142
226	Ubiquitination	SLLSSTSKYKVTIAE HHCCCCCCEEEEHHH	49.53	21963094
227	Phosphorylation	LLSSTSKYKVTIAEV HCCCCCCEEEEHHHH	15.51	30576142
230	Phosphorylation	STSKYKVTIAEVKRR CCCCEEEEHHHHHHH	15.43	28188228
239	Phosphorylation	AEVKRRLSPPECLNA HHHHHHCCCHHHHCH	36.28	-
307	Phosphorylation	LARDFGYTCETEFPA HHHHHCCCCCCCCCH	12.30	68695377
341	Phosphorylation	RKKMILATKQICKEF HHHHHHHHHHHHHHH	21.75	46164849
438	Phosphorylation	EKAPLRKTSEAAVKE CCCCCHHHHHHHHHC	25.93	50565755
439	Phosphorylation	KAPLRKTSEAAVKEG CCCCHHHHHHHHHCC	28.42	50565761
448	Phosphorylation	AAVKEGKTEKTD--- HHHHCCCCCCCC---	54.28	29209046

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
239	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP2D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP2D_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AP2D_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.