AP1S1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP1S1_MOUSE
• UniProt AC: P61967
• Protein Name: AP-1 complex subunit sigma-1A
• Gene Name: Ap1s1
• Organism: Mus musculus (Mouse).
• Sequence Length: 158
• Subcellular Localization: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
• Protein Description: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules..
• Protein Sequence: MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEWRDLKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMGGDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Ubiquitination	QGKLRLQKWYLATSD CCCHHHEEEEECCCH	42.26	27667366
26	Acetylation	WYLATSDKERKKMVR EEECCCHHHHHHHHH	60.22	23954790
36	Ubiquitination	KKMVRELMQVVLARK HHHHHHHHHHHHHCC	2.14	27667366
147	Phosphorylation	LLQEEDESPRSVLEE HHCCCCCCHHHHHHH	37.62	25521595
150	Phosphorylation	EEDESPRSVLEEMGL CCCCCHHHHHHHCCC	34.14	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP1S1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP1S1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP1S1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AP1S1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, AND MASSSPECTROMETRY.
PubMed: 17114649

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, AND MASSSPECTROMETRY.
PubMed: 17203969