AOFB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AOFB_MOUSE
• UniProt AC: Q8BW75
• Protein Name: Amine oxidase [flavin-containing] B
• Gene Name: Maob
• Organism: Mus musculus (Mouse).
• Sequence Length: 520
• Subcellular Localization: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
• Protein Description: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity)..
• Protein Sequence: MSNKSDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDNNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTKSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVIVKTLNHEIYEAKYVISAIPPALGMKIHYSPPLPMLRNQLISRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGTYAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESLDVPARPITSTFLERHLPSVPGLLKLFGLTTILSATALGFLAHKRGLFVHF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSNKSDVIV ------CCCCCCEEE	53.62	-
2	Phosphorylation	------MSNKSDVIV ------CCCCCCEEE	53.62	22871156
4	Acetylation	----MSNKSDVIVVG ----CCCCCCEEEEC	40.50	6566073
5	Phosphorylation	---MSNKSDVIVVGG ---CCCCCCEEEECC	41.16	22871156
21	Acetylation	ISGMAAAKLLHDCGL HHHHHHHHHHHHCCC	47.02	19819419
26	S-palmitoylation	AAKLLHDCGLSVVVL HHHHHHHCCCEEEEE	4.04	28526873
26	S-nitrosylation	AAKLLHDCGLSVVVL HHHHHHHCCCEEEEE	4.04	22178444
26	S-nitrosocysteine	AAKLLHDCGLSVVVL HHHHHHHCCCEEEEE	4.04	-
43	Phosphorylation	RDRVGGRTYTIRNKN HHCCCCEEEEEECCC	28.43	23984901
45	Phosphorylation	RVGGRTYTIRNKNVK CCCCEEEEEECCCCE	16.91	23984901
52	Acetylation	TIRNKNVKYVDLGGS EEECCCCEEEECCCC	49.29	23576753
52	Malonylation	TIRNKNVKYVDLGGS EEECCCCEEEECCCC	49.29	26320211
52	Ubiquitination	TIRNKNVKYVDLGGS EEECCCCEEEECCCC	49.29	27667366
73	Ubiquitination	NRILRLAKELGLETY HHHHHHHHHHCCCEE	59.05	22790023
81	Ubiquitination	ELGLETYKVNEVERL HHCCCEEEECHHHHH	46.10	-
81	Succinylation	ELGLETYKVNEVERL HHCCCEEEECHHHHH	46.10	23954790
81	Acetylation	ELGLETYKVNEVERL HHCCCEEEECHHHHH	46.10	23864654
93	Acetylation	ERLIHFVKGKSYAFR HHHHHHHCCCCCEEC	60.73	23201123
93	Ubiquitination	ERLIHFVKGKSYAFR HHHHHHHCCCCCEEC	60.73	27667366
95	Malonylation	LIHFVKGKSYAFRGP HHHHHCCCCCEECCC	34.28	26320211
95	Ubiquitination	LIHFVKGKSYAFRGP HHHHHCCCCCEECCC	34.28	27667366
136	Ubiquitination	IPSDAPWKAPLAEEW CCCCCCCCCCCHHHC	38.78	22790023
154	Ubiquitination	TMKELLDKICWTKST CHHHHHHHHHCCCCH	39.47	22790023
159	Ubiquitination	LDKICWTKSTKQIAT HHHHHCCCCHHHHHH	31.46	22790023
200	Phosphorylation	GGTTRIISTTNGGQE CCEEEEEEECCCCCE	27.14	-
201	Phosphorylation	GTTRIISTTNGGQER CEEEEEEECCCCCEE	17.55	-
209	Ubiquitination	TNGGQERKFIGGSGQ CCCCCEEEEECCCCC	40.35	22790023
222	Acetylation	GQVSERIKDILGDRV CCHHHHHHHHHCCCC	44.96	23864654
222	Ubiquitination	GQVSERIKDILGDRV CCHHHHHHHHHCCCC	44.96	27667366
222	Malonylation	GQVSERIKDILGDRV CCHHHHHHHHHCCCC	44.96	26320211
230	Ubiquitination	DILGDRVKLERPVIH HHHCCCCEEECCEEE	45.59	22790023
248	Acetylation	TGENVIVKTLNHEIY CCCEEEEEECCCHHH	35.85	23576753
248	Ubiquitination	TGENVIVKTLNHEIY CCCEEEEEECCCHHH	35.85	22790023
255	Phosphorylation	KTLNHEIYEAKYVIS EECCCHHHHHHHHHH	13.57	26032504
258	Ubiquitination	NHEIYEAKYVISAIP CCHHHHHHHHHHCCC	28.27	22790023
274	Phosphorylation	ALGMKIHYSPPLPML HHCCEEEECCCCHHH	26.75	23140645
275	Phosphorylation	LGMKIHYSPPLPMLR HCCEEEECCCCHHHH	13.09	23140645
302	Acetylation	IKCMVYYKEPFWRKK EHHEEEECCCCCCCC	41.02	23201123
363	Acetylation	TKEERLRKLCELYAK CHHHHHHHHHHHHHH	63.18	23576753
363	Ubiquitination	TKEERLRKLCELYAK CHHHHHHHHHHHHHH	63.18	-
363	Malonylation	TKEERLRKLCELYAK CHHHHHHHHHHHHHH	63.18	26320211
365	S-nitrosocysteine	EERLRKLCELYAKVL HHHHHHHHHHHHHHH	3.67	-
365	S-nitrosylation	EERLRKLCELYAKVL HHHHHHHHHHHHHHH	3.67	21278135
365	S-palmitoylation	EERLRKLCELYAKVL HHHHHHHHHHHHHHH	3.67	28526873
370	Acetylation	KLCELYAKVLNSQEA HHHHHHHHHHCCHHH	33.43	23864654
370	Ubiquitination	KLCELYAKVLNSQEA HHHHHHHHHHCCHHH	33.43	22790023
386	Acetylation	QPVHYEEKNWCEEQY CCCCCCCCCCCCHHC	43.75	23864654
397	Other	EEQYSGGCYTTYFPP CHHCCCCCCCCCCCC	2.88	-
397	S-8alpha-FAD cysteine	EEQYSGGCYTTYFPP CHHCCCCCCCCCCCC	2.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AOFB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AOFB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AOFB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AOFB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-52, AND MASS SPECTROMETRY.
PubMed: 16916647