ANXA5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA5_RAT
• UniProt AC: P14668
• Protein Name: Annexin A5
• Gene Name: Anxa5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 319
• Protein Description: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade..
• Protein Sequence: MALRGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQIAEEFKTLFGRDLVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELRAIKQAYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEKFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLENLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGGEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALRGTVTD ------CCCCCEEEC	13.13	7583670
11	Phosphorylation	RGTVTDFSGFDGRAD CCEEECCCCCCCCHH	41.16	28432305
27	Acetylation	EVLRKAMKGLGTDED HHHHHHHCCCCCCHH	56.71	22902405
31	Phosphorylation	KAMKGLGTDEDSILN HHHCCCCCCHHHHHH	41.06	22673903
35	Phosphorylation	GLGTDEDSILNLLTA CCCCCHHHHHHHHHH	27.25	22673903
41	Phosphorylation	DSILNLLTARSNAQR HHHHHHHHHCCHHHH	24.16	24259510
56	Acetylation	QQIAEEFKTLFGRDL HHHHHHHHHHHCHHH	47.82	22902405
68	Acetylation	RDLVNDMKSELTGKF HHHHHHHHHHHCCHH	43.58	22902405
74	Acetylation	MKSELTGKFEKLIVA HHHHHCCHHHHHHHH	45.15	22902405
77	Acetylation	ELTGKFEKLIVALMK HHCCHHHHHHHHHHC	46.80	22902405
84	Acetylation	KLIVALMKPSRLYDA HHHHHHHCHHHHHHH	40.46	22902405
92	Phosphorylation	PSRLYDAYELKHALK HHHHHHHHHHHHHHC	20.92	22108457
95	Acetylation	LYDAYELKHALKGAG HHHHHHHHHHHCCCC	18.19	22902405
99	Acetylation	YELKHALKGAGTDEK HHHHHHHCCCCCCHH	47.72	22902405
106	Ubiquitination	KGAGTDEKVLTEIIA CCCCCCHHHHHHHHH	45.41	-
106	Acetylation	KGAGTDEKVLTEIIA CCCCCCHHHHHHHHH	45.41	22902405
109	Phosphorylation	GTDEKVLTEIIASRT CCCHHHHHHHHHCCC	28.29	23984901
191	Acetylation	KWGTDEEKFITILGT CCCCCHHHEEEEEEC	39.76	22902405
200	Phosphorylation	ITILGTRSVSHLRRV EEEEECCCHHHHHHH	28.01	22673903
202	Phosphorylation	ILGTRSVSHLRRVFD EEECCCHHHHHHHHH	20.32	22673903
240	Acetylation	NLLLAVVKSIRSIPA HHHHHHHHHHHCCHH	33.30	22902405
258	Acetylation	ETLYYAMKGAGTDDH HHHHHHHHCCCCCCC	37.12	22902405
288	Succinylation	NIRKEFRKNFATSLY HHCHHHHHHHHHHHH	62.83	-
288	Succinylation	NIRKEFRKNFATSLY HHCHHHHHHHHHHHH	62.83	-
299	Acetylation	TSLYSMIKGDTSGDY HHHHHHHHCCCCCCH	41.93	22902405
307	Acetylation	GDTSGDYKKALLLLC CCCCCCHHHEEHHHC	35.99	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANXA5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ANXA5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.