ANS1B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANS1B_RAT
• UniProt AC: P0C6S7
• Protein Name: Ankyrin repeat and sterile alpha motif domain-containing protein 1B
• Gene Name: Anks1b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1260
• Subcellular Localization: Cytoplasm.; Isoform 2: Nucleus.; Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation t
• Protein Description: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers..
• Protein Sequence: MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQFEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQDYLEGVGRSVVLEEEHAQEDTAQETRLSSPAQSPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEDEEEDPNSCGPTGLWEALTPCNGCRNLGFPMLAQESYPKKRNYPMEIVPSASLDTFPSENENFLCELVDTAVTKKPCSLEIARAPSPRTDNASEVAITAPGTGHHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFQRMNHNQEYFEISTSTGCTSFTSSPPVSPPTSSVETTEIKNEGAEHTDDLSQQEDDEPPKEYDAGQFAGLLHGSSPACEAPENPFHLYGKRNQGEDGQEEASLANSPLPFKQTPIENNPEPSVKKIKPKVVSRTIFHKRSHQLENHTIVGTRMSRGGSRNGDQWGVNPGGFVERACTLGRIRSLPKALIDMHLSKNVSKSDSDLIAYPSKDKARVNWSKSSTAERSSKDNSERTPSFTSEWEEIDKIMNSIDVGINSELEGMNGEATRPRCPVQTVGQWLESIGLPQYENHLTANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWELELINVLKISLIGHRKRILASLGDRLHEDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDAANKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
310	Phosphorylation	TAQETRLSSPAQSPS CCHHHHCCCCCCCCC	30.87	16641100
311	Phosphorylation	AQETRLSSPAQSPSQ CHHHHCCCCCCCCCC	28.93	16641100
315	Phosphorylation	RLSSPAQSPSQKTKS HCCCCCCCCCCCCCC	28.73	28551015
317	Phosphorylation	SSPAQSPSQKTKSET CCCCCCCCCCCCCHH	49.94	28551015
320	Phosphorylation	AQSPSQKTKSETVTG CCCCCCCCCCHHHHH	31.97	16641100
354	Phosphorylation	EDLCHTISDHYLDNL HHHHHHHHHHHHHHH	21.35	-
365	Phosphorylation	LDNLSKISEEELGKN HHHHHHCCHHHHCCC	42.57	22673903
504	Phosphorylation	RNSSTGPTPDCSPPS CCCCCCCCCCCCCCC	32.86	28551015
508	Phosphorylation	TGPTPDCSPPSPDTA CCCCCCCCCCCHHHH	47.42	28551015
511	Phosphorylation	TPDCSPPSPDTALKN CCCCCCCCHHHHHHH	38.50	28551015
514	Phosphorylation	CSPPSPDTALKNIVK CCCCCHHHHHHHHHH	36.96	28551015
737	Phosphorylation	MHLSKNVSKSDSDLI HHHCCCCCCCHHCCE	35.52	25403869
739	Phosphorylation	LSKNVSKSDSDLIAY HCCCCCCCHHCCEEC	34.54	25403869
741	Phosphorylation	KNVSKSDSDLIAYPS CCCCCCHHCCEECCC	41.21	22673903
766	Phosphorylation	SSTAERSSKDNSERT CCCCCCCCCCCCCCC	50.69	25403869
773	Phosphorylation	SKDNSERTPSFTSEW CCCCCCCCCCCCHHH	21.16	22673903
775	Phosphorylation	DNSERTPSFTSEWEE CCCCCCCCCCHHHHH	40.31	22673903
901	Phosphorylation	DSIELGDYTKAFLIN HHCCCCCCCEEEEEC	14.35	1891903
954	Ubiquitination	LHEDPPQKPPRSITL HCCCCCCCCCCCEEE	63.86	-
965	Phosphorylation	SITLREPSGNHTPPQ CEEEECCCCCCCCCC	47.69	27097102
969	Phosphorylation	REPSGNHTPPQLSPS ECCCCCCCCCCCCCC	40.44	27097102
974	Phosphorylation	NHTPPQLSPSLSQST CCCCCCCCCCCCCCC	13.75	27097102
976	Phosphorylation	TPPQLSPSLSQSTYT CCCCCCCCCCCCCEE	36.96	27097102
978	Phosphorylation	PQLSPSLSQSTYTTG CCCCCCCCCCCEECC	26.82	27097102
980	Phosphorylation	LSPSLSQSTYTTGGS CCCCCCCCCEECCCC	21.72	27097102
981	Phosphorylation	SPSLSQSTYTTGGSL CCCCCCCCEECCCCC	19.76	27097102
982	Phosphorylation	PSLSQSTYTTGGSLD CCCCCCCEECCCCCC	13.93	27097102
983	Phosphorylation	SLSQSTYTTGGSLDV CCCCCCEECCCCCCC	21.03	27097102
984	Phosphorylation	LSQSTYTTGGSLDVP CCCCCEECCCCCCCC	29.18	27097102
987	Phosphorylation	STYTTGGSLDVPHII CCEECCCCCCCCEEE	23.81	27097102
1007	Phosphorylation	RRRRNENYFDDIPRS HHHCCCCCCCCCCHH	11.38	1891905
1087	Ubiquitination	STQDACAKMRANCQK CHHHHHHHHHHHHHH	28.89	-
1094	Ubiquitination	KMRANCQKSTEQMKK HHHHHHHHCHHHHHC	62.64	-
1122	Ubiquitination	KFIDAANKNIIAEHE EEECCCCCCEEEEEH	44.81	-
1208	Ubiquitination	LPESFENKPSKPIPK CCHHHCCCCCCCCCC	43.39	-
1211	Ubiquitination	SFENKPSKPIPKPRV HHCCCCCCCCCCCCE	56.33	-
1223	Phosphorylation	PRVSIRKSVQIDPSE CCEEEEECEECCHHH	14.92	25403869
1248	Ubiquitination	VEPGQEAKRGINTKY CCCCHHHCCCCCCCC	50.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANS1B_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANS1B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANS1B_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ANS1B_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.