ANO9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANO9_HUMAN
• UniProt AC: A1A5B4
• Protein Name: Anoctamin-9
• Gene Name: ANO9
• Organism: Homo sapiens (Human).
• Sequence Length: 782
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Shows predominantly an intracellular localization with a weak expression in the cell membrane.
• Protein Description: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1..
• Protein Sequence: MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRIRIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARSTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MQGEESLRILVEP --CCCCCCEEEEECC	20.74	30266825
412	Phosphorylation	CDFEMPRTFSERESR CCCCCCCCCCHHHHH	26.16	29209046
414	Phosphorylation	FEMPRTFSERESRFT CCCCCCCCHHHHHHE	34.82	46099979
418	Phosphorylation	RTFSERESRFTIRFF CCCCHHHHHHEEEEH	38.63	29209046
421	Phosphorylation	SERESRFTIRFFTLQ CHHHHHHEEEEHHHH	15.33	24719451
620	Phosphorylation	NGMVIAFTSEFIPRV CCEEEEEECCCCCCC	20.51	30576142
633	Phosphorylation	RVVYKYRYSPCLKEG CCHHCCCCCCCCCCC	17.55	50565679
634	Phosphorylation	VVYKYRYSPCLKEGN CHHCCCCCCCCCCCC	10.51	50565683
641	N-linked_Glycosylation	SPCLKEGNSTVDCLK CCCCCCCCCCHHHHH	35.28	UniProtKB CARBOHYD
652	N-linked_Glycosylation	DCLKGYVNHSLSVFH HHHHHHHCCCEEEEE	15.56	UniProtKB CARBOHYD
674	N-linked_Glycosylation	DGIEGSENVTLCRYR CCCCCCCCEEEEEEC	33.50	UniProtKB CARBOHYD
690	N-linked_Glycosylation	YRNPPDYNFSEQFWF CCCCCCCCHHHHHHH	41.15	UniProtKB CARBOHYD
770	Phosphorylation	PPMPAHPTPASIFSA CCCCCCCCCHHHHHC	22.94	29449344
773	Phosphorylation	PAHPTPASIFSARST CCCCCCHHHHHCCCC	25.93	29449344
776	Phosphorylation	PTPASIFSARSTDV- CCCHHHHHCCCCCC-	22.54	29449344
779	Phosphorylation	ASIFSARSTDV---- HHHHHCCCCCC----	28.77	29449344
780	Phosphorylation	SIFSARSTDV----- HHHHCCCCCC-----	34.92	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANO9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANO9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANO9_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ANO9_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.