ANO5_HUMAN - dbPTM
ANO5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANO5_HUMAN
UniProt AC Q75V66
Protein Name Anoctamin-5
Gene Name ANO5
Organism Homo sapiens (Human).
Sequence Length 913
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Colocalized with CALR/calreticulin (PubMed:15124103). Shows an intracellular localization according to PubMed:22075693.
Protein Description Does not exhibit calcium-activated chloride channel (CaCC) activity..
Protein Sequence MGDPDLLEVLAEEGEKVNKHIDYSFQMSEQSLSSRETSFLINEETMPAKRFNLFLRRRLMFQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDAELKAERRKEFETNLRKTGLELEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHTPISYVLGPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSMVAVIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEKLYSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLKENLGINSNEFAKHVMIEENKAQLAKSTL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
97UbiquitinationVKKDAELKAERRKEF
HHHHHHHHHHHHHHH		39.44-
128PhosphorylationRDSEDGRTYFVKIHA
CCCCCCCEEEEEEEC		27.1721601215
254UbiquitinationSSAYPLHDGQYWKPS
CCCEECCCCCCCCCC		54.2822817900
259UbiquitinationLHDGQYWKPSEPPNP
CCCCCCCCCCCCCCC		33.4622817900
270UbiquitinationPPNPTNERYTLHQNW
CCCCCCCCEEEECCC		31.6322817900
271UbiquitinationPNPTNERYTLHQNWA
CCCCCCCEEEECCCH		13.8922817900
284UbiquitinationWARFSYFYKEQPLDL
CHHHHHEECCCCHHH		12.8422817900
285UbiquitinationARFSYFYKEQPLDLI
HHHHHEECCCCHHHH		39.7222817900
335N-linked_GlycosylationGLLSMEHNTSSTEIC
HHHHCCCCCCCCCCC		28.49UniProtKB CARBOHYD
366N-linked_GlycosylationVCDYWRLNSTCLASK
HCHHHHCCCHHHHHH		27.05UniProtKB CARBOHYD
380N-linked_GlycosylationKFSHLFDNESTVFFA
HHHHHCCCCHHHHHH		37.47UniProtKB CARBOHYD
444UbiquitinationRKLNAVTKEMEPYMP
HHHHHHCCCCCCCCC		48.76-
449PhosphorylationVTKEMEPYMPLYTRI
HCCCCCCCCCCHHCC		9.6920564061
453PhosphorylationMEPYMPLYTRIPWYF
CCCCCCCHHCCCCHH		6.5220564067
454PhosphorylationEPYMPLYTRIPWYFL
CCCCCCHHCCCCHHH		29.7968724793
459PhosphorylationLYTRIPWYFLSGATV
CHHCCCCHHHCCHHH		6.8424043423
462PhosphorylationRIPWYFLSGATVTLW
CCCCHHHCCHHHHHH		19.2424043423
465PhosphorylationWYFLSGATVTLWMSL
CHHHCCHHHHHHHHH		19.9724043423
467PhosphorylationFLSGATVTLWMSLVV
HHCCHHHHHHHHHHH		15.4524043423
471PhosphorylationATVTLWMSLVVTSMV
HHHHHHHHHHHHHHH		13.3624043423
475PhosphorylationLWMSLVVTSMVAVIV
HHHHHHHHHHHHHHH		12.0224043423
476PhosphorylationWMSLVVTSMVAVIVY
HHHHHHHHHHHHHHH		10.3124043423
483PhosphorylationSMVAVIVYRLSVFAT
HHHHHHHHHHHHHHH		8.5024043423
555PhosphorylationTYQEYESSLTLKMFL
CHHHHHHHHHHHHHH		17.2768726943
650UbiquitinationKARTNSEKLYSRWEQ
HCCCCHHHHHHHHHH		53.17-
653PhosphorylationTNSEKLYSRWEQDHD
CCHHHHHHHHHHCCC		41.1624719451
711UbiquitinationEIRVDAWKLTTQYRR
EEECCHHHHCHHHHH		37.36-
768N-linked_GlycosylationYYYAYSTNATQPMTG
HHHHCCCCCCCCCCE		34.74UniProtKB CARBOHYD
778N-linked_GlycosylationQPMTGYVNNSLSVFL
CCCCEEECCCEEEEE		24.72UniProtKB CARBOHYD
791N-linked_GlycosylationFLIADFPNHTAPSEK
EEEECCCCCCCCCHH		45.17UniProtKB CARBOHYD
803PhosphorylationSEKRDFITCRYRDYR
CHHCCEEEEEECCCC		7.3026074081
806PhosphorylationRDFITCRYRDYRYPP
CCEEEEEECCCCCCC		15.2426074081
809PhosphorylationITCRYRDYRYPPDDE
EEEEECCCCCCCCCC		11.7526074081
897AcetylationINSNEFAKHVMIEEN
CCCHHHHHHHHHHHH		41.8911494463
905AcetylationHVMIEENKAQLAKST
HHHHHHHHHHHHHHC		40.5711494471
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANO5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANO5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANO5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ANO5_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ANO5_HUMAN

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Related Literatures of Post-Translational Modification

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