ANO1_HUMAN - dbPTM
ANO1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANO1_HUMAN
UniProt AC Q5XXA6
Protein Name Anoctamin-1
Gene Name ANO1
Organism Homo sapiens (Human).
Sequence Length 986
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cytoplasm . Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.
Protein Description Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development..
Protein Sequence MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MRVNEKYSTLPAED
-CCCCCCCCCCCCCC		10.7425394399
8PhosphorylationMRVNEKYSTLPAEDR
CCCCCCCCCCCCCCC		34.2428152594
9PhosphorylationRVNEKYSTLPAEDRS
CCCCCCCCCCCCCCC		33.4028152594
54PhosphorylationAECKYGLYFRDGRRK
CCCCCEEEEECCCEE		7.6946306917
64PhosphorylationDGRRKVDYILVYHHK
CCCEEEEEEEEEECC		10.11110752891
78PhosphorylationKRPSGNRTLVRRVQH
CCCCCCCEEEEEEEC		33.3469002857
84 (in isoform 2)Ubiquitination-28.67-
86PhosphorylationLVRRVQHSDTPSGAR
EEEEEECCCCCCCCC		26.5369002965
88PhosphorylationRRVQHSDTPSGARSV
EEEECCCCCCCCCCC		23.51101546357
90PhosphorylationVQHSDTPSGARSVKQ
EECCCCCCCCCCCCC		47.3727794612
94PhosphorylationDTPSGARSVKQDHPL
CCCCCCCCCCCCCCC		32.8827470641
104MethylationQDHPLPGKGASLDAG
CCCCCCCCCCCCCCC		49.7323644510
104"N6,N6-dimethyllysine"QDHPLPGKGASLDAG
CCCCCCCCCCCCCCC		49.73-
107PhosphorylationPLPGKGASLDAGSGE
CCCCCCCCCCCCCCC		35.1427050516
112PhosphorylationGASLDAGSGEPPMDY
CCCCCCCCCCCCCCC		41.5228985074
119PhosphorylationSGEPPMDYHEDDKRF
CCCCCCCCCCCCCCH		10.8022817900
182PhosphorylationKMPTKKMYHINETRG
CCCCCCEECCHHHHH		14.398265359
183 (in isoform 2)Ubiquitination-16.95-
187PhosphorylationKMYHINETRGLLKKI
CEECCHHHHHHHHHH		26.0846306911
196PhosphorylationGLLKKINSVLQKITD
HHHHHHHHHHHHHCC		27.9014702039
197 (in isoform 2)Ubiquitination-5.92-
221PhosphorylationPQTMKRLSYPFSREK
CCHHHHHCCCCCCCC		34.4922985185
222PhosphorylationQTMKRLSYPFSREKQ
CHHHHHCCCCCCCCH		16.9427794612
225PhosphorylationKRLSYPFSREKQHLF
HHHCCCCCCCCHHCC		34.7223312004
243PhosphorylationDKDSFFDSKTRSTIV
CCCCCCCCCCCHHHH		30.67110752897
251PhosphorylationKTRSTIVYEILKRTT
CCCHHHHHHHHHHCC		8.0622209989
261AcetylationLKRTTCTKAKYSMGI
HHHCCCCCCCCCCCH		45.067910715
302PhosphorylationFNDRKLLYEEWARYG
CCCHHHHHHHHHHHC		23.4122209997
313UbiquitinationARYGVFYKYQPIDLV
HHHCCEECCCCHHHH		26.41-
314PhosphorylationRYGVFYKYQPIDLVR
HHCCEECCCCHHHHH		14.2421696537
401PhosphorylationACATARASHLFDNPA
HHHHHHHHHHCCCHH		18.3726074081
409PhosphorylationHLFDNPATVFFSVFM
HHCCCHHHHHHHHHH		21.0726074081
413PhosphorylationNPATVFFSVFMALWA
CHHHHHHHHHHHHHH		11.7226074081
422PhosphorylationFMALWAATFMEHWKR
HHHHHHHHHHHHHHH		18.7726074081
446 (in isoform 2)Ubiquitination-54.6721906983
451 (in isoform 1)Ubiquitination-58.3221906983
451UbiquitinationEEEEEAVKDHPRAEY
HHHHHHHHHCCHHHH		58.3221906983
466PhosphorylationEARVLEKSLKKESRN
HHHHHHHHHHHHHCC		35.7322210691
471PhosphorylationEKSLKKESRNKEKRR
HHHHHHHHCCHHHHC		50.4624719451
534 (in isoform 3)Ubiquitination-3.2321906983
555PhosphorylationLAMNSSPSVRSNIRV
HHHCCCCCHHCCCCC		31.9146306899
592 (in isoform 1)Ubiquitination-34.4021906983
592UbiquitinationCIARWLTKIEVPKTE
HHHHHHHHCCCCCCC		34.40-
601PhosphorylationEVPKTEKSFEERLIF
CCCCCCCCHHHHHHH		31.4924719451
635 (in isoform 2)Ubiquitination-27.08-
692PhosphorylationKMKKLIRYLKLKQQS
HHHHHHHHHHHHCCC		10.9528258704
770PhosphorylationLDAKKFVTELRRPVA
CCHHHHHHHHCCCCE		32.2230622161
795 (in isoform 2)Ubiquitination-31.2121906983
805 (in isoform 2)Ubiquitination-1.9621906983
806PhosphorylationIINAFVISFTSDFIP
HHHHHHHHCCCCCHH		19.7123532336
808PhosphorylationNAFVISFTSDFIPRL
HHHHHHCCCCCHHHH		22.1623532336
822PhosphorylationLVYLYMYSKNGTMHG
HHHEEEECCCCCEEE		11.7824719451
832N-linked_GlycosylationGTMHGFVNHTLSSFN
CCEEEEEECCCCCCC		21.84UniProtKB CARBOHYD
941UbiquitinationFMREEQDKQQLLETW
HCCHHHHHHHHHHHH		39.3721906983
941 (in isoform 1)Ubiquitination-39.3721906983
951UbiquitinationLLETWMEKERQKDEP
HHHHHHHHHHCCCCC		41.932190698
951 (in isoform 1)Ubiquitination-41.9321906983
971PhosphorylationNTKACPDSLGSPAPS
CCCCCCCCCCCCCCC		21.5522617229
974PhosphorylationACPDSLGSPAPSHAY
CCCCCCCCCCCCCCC		24.1526657352
978PhosphorylationSLGSPAPSHAYHGGV
CCCCCCCCCCCCCCC		23.9027259358
981PhosphorylationSPAPSHAYHGGVL--
CCCCCCCCCCCCC--		8.79120881
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANO1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANO1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANO1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ANO1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB04941Crofelemer
Regulatory Network of ANO1_HUMAN

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Related Literatures of Post-Translational Modification

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