ANKR6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANKR6_MOUSE
• UniProt AC: Q69ZU8
• Protein Name: Ankyrin repeat domain-containing protein 6
• Gene Name: Ankrd6
• Organism: Mus musculus (Mouse).
• Sequence Length: 712
• Protein Description: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals..
• Protein Sequence: MSQQDAVAALSERLLIAAYKGQTENVVQLINKGAKVAVTKHGRTPLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALDRQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRILLLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLNAFCSVHEKNQAGDTALHVAAALNHKKVVKVLLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQILRFSRGRSLRKRRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPQKEEARRDCPPASQEPRKDERRRKSRPEVSALSDPTPAADQQPGHQKNLHSHHHPKKKSRHRCWSPPPPHGFRAYQLYTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEATVEEIRAELGSVQDKVNAKLGQMESKTQHQMCVLDKLMVERLSAERTECMNRLQQHAAAEKQEGEKRQMSLVDELKAWCMLKIQSLELRLSGESRTFRAKSTPPPSDSTPAVDQPVVAAGPGAASDSSSQVVRPKDKALNASAAHSHQQELPPSDCTGSGLRKIKAPGASRCDQQTGSCVNRGTQTKKSGRSGQTKHRGQQPTASSPSGQQPSAASSDVRDASQALELTQYFFEAVSAQMEKWYERKIEEARSQASQKAQQDEATLKEHIRSLEEELARLRTKVQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	IAAYKGQTENVVQLI HHHHCCCCHHHHHHH	37.89	24719451
39	Phosphorylation	KGAKVAVTKHGRTPL CCCCEEEECCCCCCH	13.95	24719451
40	Ubiquitination	GAKVAVTKHGRTPLH CCCEEEECCCCCCHH	37.15	-
289	Phosphorylation	KEERRAQSVPRDEVA HHHHHHHCCCHHHHH	32.86	28066266
340	Phosphorylation	KDERRRKSRPEVSAL HHHHHHHCCCCHHHH	51.78	29899451
345	Phosphorylation	RKSRPEVSALSDPTP HHCCCCHHHHCCCCC	23.10	29899451
427	Phosphorylation	LENQLEATVEEIRAE HHHHHHHHHHHHHHH	21.05	24719451
469	Phosphorylation	KLMVERLSAERTECM HHHHHHHHHHHHHHH	34.01	24719451
632	Phosphorylation	GQQPTASSPSGQQPS CCCCCCCCCCCCCCC	22.18	29899451
643	Phosphorylation	QQPSAASSDVRDASQ CCCCCCCCCHHCHHH	35.08	29899451
679	Phosphorylation	RKIEEARSQASQKAQ HHHHHHHHHHHHHHH	36.83	23375375
682	Phosphorylation	EEARSQASQKAQQDE HHHHHHHHHHHHHCH	25.28	23375375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANKR6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANKR6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANKR6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ANKR6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.