dbPTM

ANKR6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANKR6_HUMAN
UniProt AC	Q9Y2G4
Protein Name	Ankyrin repeat domain-containing protein 6
Gene Name	ANKRD6
Organism	Homo sapiens (Human).
Sequence Length	727
Subcellular Localization
Protein Description	Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals..
Protein Sequence	MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQQDAVAA ------CCHHHHHHH	36.23	24719451
40	Ubiquitination	GARVAVTKHGRTPLH CCCEEEECCCCCCHH	37.15	17370265
52	Ubiquitination	PLHLAANKGHLPVVQ CHHHHCCCCCCCHHH	42.87	-
289	Phosphorylation	KEERRAQSVPRDEVA HHHHHHHCCCHHHHH	32.86	25850435
299	Acetylation	RDEVAQSKGSVSAGD HHHHHHCCCCCCCCC	43.03	20167786
326	Phosphorylation	EAREEFLSASPEPRA HHHHHHHHCCCCCCC	31.83	28857561
328	Phosphorylation	REEFLSASPEPRAKD HHHHHHCCCCCCCHH	26.81	27966365
349	Phosphorylation	RPKVSAFSDPTPPAD CCCCCCCCCCCCCHH	42.25	101546287
352	Phosphorylation	VSAFSDPTPPADQQP CCCCCCCCCCHHCCC	47.06	28348404
391	Phosphorylation	PPHEFRAYQLYTLYR CCHHHHHHHEEEEEE	8.52	28270605
394	Phosphorylation	EFRAYQLYTLYRGKD HHHHHHEEEEEECCC	4.52	28270605
395	Phosphorylation	FRAYQLYTLYRGKDG HHHHHEEEEEECCCC	26.38	28270605
397	Phosphorylation	AYQLYTLYRGKDGKV HHHEEEEEECCCCCE	14.98	28270605
438	Phosphorylation	EIKAELGSVQDKMNT HHHHHHCCHHHHHHH	29.27	26074081
445	Phosphorylation	SVQDKMNTKLGQMEN CHHHHHHHHHHHHCC	24.93	26074081
454	Phosphorylation	LGQMENKTQHQMRVL HHHHCCHHHHHHHHH	42.75	26074081
470	Phosphorylation	KLMVERLSAERTECL HHHHHHHHHHHHHHH	34.01	24719451
484	Phosphorylation	LNRLQQHSDTEKHEG HHHHHHHCCCCCCCC	41.72	24719451
497	Phosphorylation	EGEKRQISLVDELKT CCCCCEEHHHHHHHH	17.63	20815847
518	Phosphorylation	QNLEQKLSGDSRACR HCHHHHHCCCCCHHH	47.81	20815857
532	Phosphorylation	RAKSTPSTCESSTGV HCCCCCCCCCCCCCC	22.84	28961369
535	Phosphorylation	STPSTCESSTGVDQL CCCCCCCCCCCCCEE	35.03	28961369
536	Phosphorylation	TPSTCESSTGVDQLV CCCCCCCCCCCCEEE	13.59	28961369
537	Phosphorylation	PSTCESSTGVDQLVV CCCCCCCCCCCEEEE	50.97	28961369
545	Phosphorylation	GVDQLVVTAGPAAAS CCCEEEEEECCCCCC	20.58	28961369
552	Phosphorylation	TAGPAAASDSSPPVV EECCCCCCCCCCCCC	33.04	28857561
622	Acetylation	NRGTQTKKSGKSGPT CCCCCCCCCCCCCCC	68.76	19815767
626	Phosphorylation	QTKKSGKSGPTRHRA CCCCCCCCCCCCCCC	54.23	23532336
692	Phosphorylation	RKIEEARSQANQKAQ HHHHHHHHHHHHHHH	40.47	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANKR6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANKR6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANKR6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AXIN2_HUMAN	AXIN2	physical	12183362
GSK3B_HUMAN	GSK3B	physical	12183362
KC1E_HUMAN	CSNK1E	physical	12183362

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANKR6_HUMAN

Related Literatures of Post-Translational Modification

Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-40, AND MASSSPECTROMETRY.	17370265 [Abstract]